A meningococcal factor H binding protein mutant that eliminates factor H binding enhances protective antibody responses to vaccination
about
Molecular basis of host specificity in human pathogenic bacteriaRole of factor H binding protein in Neisseria meningitidis virulence and its potential as a vaccine candidate to broadly protect against meningococcal diseaseVirulence of Group A Streptococci Is Enhanced by Human Complement InhibitorsDesign and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen MoleculesProtein Crystallography in Vaccine Research and DevelopmentMonoclonal antibodies to meningococcal factor H binding protein with overlapping epitopes and discordant functional activityAnalysis of the complement sensitivity of oral treponemes and the potential influence of FH binding, FH cleavage and dentilisin activity on the pathogenesis of periodontal disease.Human factor H (FH) impairs protective meningococcal anti-FHbp antibody responses and the antibodies enhance FH bindingThe effect of human factor H on immunogenicity of meningococcal native outer membrane vesicle vaccines with over-expressed factor H binding protein.Meningococcal disease and the complement system.Heterogeneity in rhesus macaque complement factor H binding to meningococcal factor H binding protein (FHbp) informs selection of primates to assess immunogenicity of FHbp-based vaccines.Mutant Native Outer Membrane Vesicles Combined with a Serogroup A Polysaccharide Conjugate Vaccine for Prevention of Meningococcal Epidemics in Africa.Sterilizing immunity elicited by Neisseria meningitidis carriage shows broader protection than predicted by serum antibody cross-reactivity in CEACAM1-humanized mice.Distinct binding and immunogenic properties of the gonococcal homologue of meningococcal factor h binding proteinA critical threshold of meningococcal factor H binding protein expression is required for increased breadth of protective antibodies elicited by native outer membrane vesicle vaccinesα-2,3-sialyltransferase expression level impacts the kinetics of lipooligosaccharide sialylation, complement resistance, and the ability of Neisseria gonorrhoeae to colonize the murine genital tractA native outer membrane vesicle vaccine confers protection against meningococcal colonization in human CEACAM1 transgenic mice.Binding of complement factor H to PorB3 and NspA enhances resistance of Neisseria meningitidis to anti-factor H binding protein bactericidal activity.Complement-mediated bactericidal activity of anti-factor H binding protein monoclonal antibodies against the meningococcus relies upon blocking factor H binding.Meningococcal factor H binding proteins in epidemic strains from Africa: implications for vaccine development.Neisseria gonorrhoeae NspA induces specific bactericidal and opsonic antibodies in miceA Mutant Library Approach to Identify Improved Meningococcal Factor H Binding Protein Vaccine Antigens.Combined roles of human IgG subclass, alternative complement pathway activation, and epitope density in the bactericidal activity of antibodies to meningococcal factor h binding protein.Enhanced bacteremia in human factor H transgenic rats infected by Neisseria meningitidisA Newly-Identified Polymorphism in Rhesus Macaque Complement Factor H Modulates Binding Affinity for Meningococcal FHbp.Functional Analysis of the Human Antibody Response to Meningococcal Factor H Binding ProteinA broadly cross-reactive monoclonal antibody against an epitope on the n-terminus of meningococcal fHbp.Cross-reactivity of antipneumococcal surface protein C (PspC) antibodies with different strains and evaluation of inhibition of human complement factor H and secretory IgA binding via PspC.Impact of Reducing Complement Inhibitor Binding on the Immunogenicity of Native Neisseria meningitidis Outer Membrane Vesicles.Binding of Complement Factor H (FH) Decreases Protective Anti-FH Binding Protein Antibody Responses of Infant Rhesus Macaques Immunized With a Meningococcal Serogroup B Vaccine.The new multicomponent vaccine against meningococcal serogroup B, 4CMenB: immunological, functional and structural characterization of the antigens.Beyond the Crystal Structure: Insight into the Function and Vaccine Potential of TbpA Expressed by Neisseria gonorrhoeae.Design of meningococcal factor H binding protein mutant vaccines that do not bind human complement factor H.Susceptibility of Meningococcal Strains Responsible for Two Serogroup B Outbreaks on U.S. University Campuses to Serum Bactericidal Activity Elicited by the MenB-4C VaccineA meningococcal vaccine antigen engineered to increase thermal stability and stabilize protective epitopes.Effect of complement Factor H on anti-FHbp serum bactericidal antibody responses of infant rhesus macaques boosted with a licensed meningococcal serogroup B vaccineModulation of nasopharyngeal innate defenses by viral coinfection predisposes individuals to experimental pneumococcal carriageImpaired Immunogenicity of Meningococcal Neisserial Surface Protein A in Human Complement Factor H Transgenic Mice.A meningococcal NOMV-FHbp vaccine for Africa elicits broader serum bactericidal antibody responses against serogroup B and non-B strains than a licensed serogroup B vaccineMeningococcal Factor H Binding Protein Vaccine Antigens with Increased Thermal Stability and Decreased Binding of Human Factor H.
P2860
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P2860
A meningococcal factor H binding protein mutant that eliminates factor H binding enhances protective antibody responses to vaccination
description
2011 nî lūn-bûn
@nan
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
A meningococcal factor H bindi ...... ibody responses to vaccination
@ast
A meningococcal factor H bindi ...... ibody responses to vaccination
@en
A meningococcal factor H bindi ...... ibody responses to vaccination
@nl
type
label
A meningococcal factor H bindi ...... ibody responses to vaccination
@ast
A meningococcal factor H bindi ...... ibody responses to vaccination
@en
A meningococcal factor H bindi ...... ibody responses to vaccination
@nl
prefLabel
A meningococcal factor H bindi ...... ibody responses to vaccination
@ast
A meningococcal factor H bindi ...... ibody responses to vaccination
@en
A meningococcal factor H bindi ...... ibody responses to vaccination
@nl
P2093
P2860
P356
P1476
A meningococcal factor H bindi ...... ibody responses to vaccination
@en
P2093
Dan M Granoff
Emily M Braga
Jutamas Shaughnessy
Peter A Rice
Peter T Beernink
Sanjay Ram
P2860
P304
P356
10.4049/JIMMUNOL.1003470
P407
P577
2011-02-16T00:00:00Z