p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR. - Wikidata - awgldk - TriplyDB

p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR.

p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR.

http://www.wikidata.org/entity/Q34995182

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Regulation of AU-Rich Element RNA Binding Proteins by Phosphorylation and the Prolyl Isomerase Pin1 mTOR and MAPK: from localized translation control to epilepsy Prolactin increases SMN expression and survival in a mouse model of severe spinal muscular atrophy via the STAT5 pathway.Activation of p38 MAP kinase and JNK pathways by UVA irradiation From a traditional medicinal plant to a rational drug: understanding the clinically proven wound healing efficacy of birch bark extract Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.A screen for regulators of survival of motor neuron protein levels Post-transcriptional control during chronic inflammation and cancer: a focus on AU-rich elements.Therapeutic strategies for the treatment of spinal muscular atrophy.Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment.Small molecule screen reveals regulation of survival motor neuron protein abundance by Ras proteins.Targeting SR proteins improves SMN expression in spinal muscular atrophy cells.Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds Altered regulation of ELAVL1/HuR in HLA-B27-expressing U937 monocytic cells.Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation.Discovering and validating unknown phospho-sites from p38 and HuR protein kinases in vitro by Phosphoproteomic and Bioinformatic tools HuR function in disease.The MK2/HuR signaling pathway regulates TNF-α-induced ICAM-1 expression by promoting the stabilization of ICAM-1 mRNA Altered mRNA Splicing in SMN-Depleted Motor Neuron-Like Cells.Mechanistic principles of antisense targets for the treatment of spinal muscular atrophy U1A regulates 3' processing of the survival motor neuron mRNA.Multilayered control of gene expression by stress-activated protein kinases.A generalizable pre-clinical research approach for orphan disease therapy Osmostress-induced gene expression--a model to understand how stress-activated protein kinases (SAPKs) regulate transcription UsnRNP biogenesis: mechanisms and regulation.NGS Technologies as a Turning Point in Rare Disease Research , Diagnosis and Treatment.Hypothermia improves disease manifestations in SMA mice via SMN augmentation.Muscle-specific expression of the RNA-binding protein Staufen1 induces progressive skeletal muscle atrophy via regulation of phosphatase tensin homolog.Diverse role of survival motor neuron protein.VPAC2 receptor agonist BAY 55-9837 increases SMN protein levels and moderates disease phenotype in severe spinal muscular atrophy mouse models.RNA-binding proteins as a point of convergence of the PI3K and p38 MAPK pathways.p38 MAPK down-regulates fibulin 3 expression through methylation of gene regulatory sequences: role in migration and invasion.Sodium Channel Inhibitors Reduce DMPK mRNA and Protein.SMN regulation in SMA and in response to stress: new paradigms and therapeutic possibilities.Regulation of Postoperative Ileus by Lentivirus-Mediated HuR RNA Interference via the p38/MK2 Signaling Pathway.mRNA stability as a function of striated muscle oxidative capacity.A-44G transition in SMN2 intron 6 protects patients with spinal muscular atrophy.HuR (Elavl1) and HuB (Elavl2) Stabilize Matrix Metalloproteinase-9 mRNA During Seizure-Induced Mmp-9 Expression in Neurons.Autophagy Stimulus Promotes Early HuR Protein Activation and p62/SQSTM1 Protein Synthesis in ARPE-19 Cells by Triggering Erk1/2, p38MAPK, and JNK Kinase Pathways.A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

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P2860

p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR.

http://www.wikidata.org/entity/Q34995182

description

2009 nî lūn-bûn

@nan

2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR.

@ast

p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR.

@en

p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR.

@nl

type

label

p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR.

@ast

p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR.

@en

p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR.

@nl

prefLabel

p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR.

@ast

p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR.

@en

p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR.

@nl

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Human Molecular Genetics

P1476

p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR

@en

P2093

Alex MacKenzie

http://www.w3.org/2001/XMLSchema#string

Faraz Farooq

http://www.w3.org/2001/XMLSchema#string

Sylvia Balabanian

http://www.w3.org/2001/XMLSchema#string

Xuejun Liu

http://www.w3.org/2001/XMLSchema#string

P2860

Coupled in vitro import of U snRNPs and SMN, the spinal muscular atrophy protein

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis

DcpS as a therapeutic target for spinal muscular atrophy.

Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)

SMN interacts with a novel family of hnRNP and spliceosomal proteins

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

A functional interaction between the survival motor neuron complex and RNA polymerase II

Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy

Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins

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4035-4045

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scholarly article

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10.1093/HMG/DDP352

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21

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18

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2009-07-31T00:00:00Z

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26710690

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19648294

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