Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal molecules - Wikidata - awgldk - TriplyDB

Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal molecules

Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal molecules

http://www.wikidata.org/entity/Q34995642

about

Insights into eisosome assembly and organization Iron, glucose and intrinsic factors alter sphingolipid composition as yeast cells enter stationary phase.Antifungal drug discovery: something old and something new Host-mediated Leishmania donovani treatment using AR-12 encapsulated in acetalated dextran microparticles.Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase.The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis.Membrane Compartment Occupied by Can1 (MCC) and Eisosome Subdomains of the Fungal Plasma Membrane.The RAM network in pathogenic fungi.Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance and survival in murine phagocytes Stress signaling pathways for the pathogenicity of Cryptococcus.Beneficial effects of sulfonamide‑based gallates on osteoblasts in vitro.Antifungal therapeutics for dimorphic fungal pathogens.The antifungal pipeline: a reality check.Drugs currently under investigation for the treatment of invasive candidiasis.Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi.High-Throughput Screen in Cryptococcus neoformans Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling.AR-13, a Celecoxib Derivative, Directly Kills Francisella In Vitro and Aids Clearance and Mouse Survival In Vivo.The celecoxib derivatives AR-12 and AR-14 induce autophagy and clear prion-infected cells from prions.New Horizons in Antifungal Therapy.The activation loop of PKA catalytic isoforms is differentially phosphorylated by Pkh protein kinases in Saccharomyces cerevisiae.

P2860

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P2860

Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal molecules

http://www.wikidata.org/entity/Q34995642

description

2011 nî lūn-bûn

@nan

2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Identification, in vitro activ ...... bitors as antifungal molecules

@ast

Identification, in vitro activ ...... bitors as antifungal molecules

@en

Identification, in vitro activ ...... bitors as antifungal molecules

@nl

type

label

Identification, in vitro activ ...... bitors as antifungal molecules

@ast

Identification, in vitro activ ...... bitors as antifungal molecules

@en

Identification, in vitro activ ...... bitors as antifungal molecules

@nl

prefLabel

Identification, in vitro activ ...... bitors as antifungal molecules

@ast

Identification, in vitro activ ...... bitors as antifungal molecules

@en

Identification, in vitro activ ...... bitors as antifungal molecules

@nl

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ACS Chemical Biology

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Identification, in vitro activ ...... bitors as antifungal molecules

@en

P2093

Bonnie K Baxter

http://www.w3.org/2001/XMLSchema#string

Damian J Krysan

http://www.w3.org/2001/XMLSchema#string

Duana Ogu

http://www.w3.org/2001/XMLSchema#string

Louis DiDone

http://www.w3.org/2001/XMLSchema#string

Stanford Schor

http://www.w3.org/2001/XMLSchema#string

P2860

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition

A protein kinase network regulates the function of aminophospholipid flippases.

Pkh-kinases control eisosome assembly and organization.

The sphingolipid long-chain base-Pkh1/2-Ypk1/2 signaling pathway regulates eisosome assembly and turnover.

Regulation of the yeast Rlm1 transcription factor by the Mpk1 cell wall integrity MAP kinase.

Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast.

PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast.

An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis

Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast

PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90

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502-510

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scholarly article

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10.1021/CB100399X

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5

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6

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21294551

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3098953

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