Metalloprotease ADAM10 is required for Notch1 site 2 cleavage. - Wikidata - awgldk - TriplyDB

Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.

Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.

http://www.wikidata.org/entity/Q35000965

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TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.Regulating Axonal Responses to Injury: The Intersection between Signaling Pathways Involved in Axon Myelination and The Inhibition of Axon Regeneration A Disintegrin and Metalloprotease (ADAM): Historical Overview of Their Functions Targeting Notch to overcome radiation resistance Force-induced unfolding simulations of the human Notch1 negative regulatory region: possible roles of the heterodimerization domain in mechanosensing Increase of ADAM10 level in coronary artery in-stent restenosis segments in diabetic minipigs: high ADAM10 expression promoting growth and migration in human vascular smooth muscle cells via Notch 1 and 3 How Tissue Mechanical Properties Affect Enteric Neural Crest Cell Migration Notch ligand endocytosis: mechanistic basis of signaling activity Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin Growth Arrest Specific 2 (GAS2) is a Critical Mediator of Germ Cell Cyst Breakdown and Folliculogenesis in Mice.Conservation and divergence of ADAM family proteins in the Xenopus genome.Direct observation of proteolytic cleavage at the S2 site upon forced unfolding of the Notch negative regulatory region Noncanonical NOTCH signaling limits self-renewal of human epithelial and induced pluripotent stem cells through ROCK activation.Turn It Down a Notch ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo.Notch: architect, landscaper, and guardian of the intestine.Mammary development and breast cancer: the role of stem cells Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin.TACE (ADAM17) inhibits Schwann cell myelination.A Disintegrin and Metalloprotease 10 in neuronal maturation and gliogenesis during cortex development.ADAM10 is required for SCF-induced mast cell migration Role of glycans and glycosyltransferases in the regulation of Notch signaling γ-secretase-dependent cleavage initiates notch signaling from the plasma membrane The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.Targeting Notch Signaling in Colorectal Cancer.ADAM17 is critical for multipolar exit and radial migration of neuronal intermediate progenitor cells in mice cerebral cortex Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis.Differential surface expression of ADAM10 and ADAM17 on human T lymphocytes and tumor cells.Metalloprotease-disintegrin ADAM12 expression is regulated by Notch signaling via microRNA-29.Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures.Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity An overview of notch signaling in adult tissue renewal and maintenance.Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL.The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis All in the Family: How the APPs Regulate Neurogenesis Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins A Disintegrin and Metalloproteinase10 (ADAM10) Regulates NOTCH Signaling during Early Retinal Development.Real-time imaging of notch activation with a luciferase complementation-based reporter.

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P2860

Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.

http://www.wikidata.org/entity/Q35000965

description

2009 nî lūn-bûn

@nan

2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.

@ast

Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.

@en

type

label

Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.

@ast

Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.

@en

prefLabel

Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.

@ast

Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.

@en

P1433

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P356

JBC.M109.006775

P1433

Journal of Biological Chemistry

P1476

Metalloprotease ADAM10 is required for Notch1 site 2 cleavage

@en

P2093

Elsken van der Wall

http://www.w3.org/2001/XMLSchema#string

Geert van Tetering

http://www.w3.org/2001/XMLSchema#string

Ingrid Verlaan

http://www.w3.org/2001/XMLSchema#string

Marc Vooijs

http://www.w3.org/2001/XMLSchema#string

Paul van Diest

http://www.w3.org/2001/XMLSchema#string

P2860

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase

Structural basis for autoinhibition of Notch

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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31018-31027

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scholarly article

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10.1074/JBC.M109.006775

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45

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284

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19726682

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2781502

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