Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection
about
Role of PD-1 in HIV pathogenesis and as target for therapyAssociation of HLA-alleles with the immune regulation of chronic viral infectionsCytokine production and dysregulation in HIV pathogenesis: lessons for development of therapeutics and vaccinesFoxo3a: an integrator of immune dysfunction during HIV infectionDeveloping Combined HIV Vaccine Strategies for a Functional CureTIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV InfectionInnate and Adaptive Immune Regulation During Chronic Viral InfectionsCD8(+) T-cell effector function and transcriptional regulation during HIV pathogenesisHTLV-1 specific CD8+ T cell function augmented by blockade of 2B4/CD48 interaction in HTLV-1 infectionHumoral and Innate Antiviral Immunity as Tools to Clear Persistent HIV InfectionT-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infectionEarly skewed distribution of total and HIV-specific CD8+ T-cell memory phenotypes during primary HIV infection is related to reduced antiviral activity and faster disease progressionInhibitory phenotype of HBV-specific CD4+ T-cells is characterized by high PD-1 expression but absent coregulation of multiple inhibitory moleculesProgrammed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load.Exhaustion of bacteria-specific CD4 T cells and microbial translocation in common variable immunodeficiency disorders.Lymphocyte activation gene-3 expression defines a discrete subset of HIV-specific CD8+ T cells that is associated with lower viral loadCD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction.Immunogenetics of small ruminant lentiviral infectionsRole of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic optionsEpitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations.Elevated expression of LAG-3, but not PD-1, is associated with impaired iNKT cytokine production during chronic HIV-1 infection and treatment.Responsiveness of HIV-specific CD4 T cells to PD-1 blockadeDeconvolving heterogeneity in the CD8+ T-cell response to HIV.Initiation of Antiretroviral Therapy (ART) at Different Stages of HIV-1 Disease Is Not Associated with the Proportion of Exhausted CD8+ T CellsUpdate on hepatitis C virus-specific immunityProlonged Antiretroviral Therapy Preserves HIV-1-Specific CD8 T Cells with Stem Cell-Like PropertiesPositive and negative regulation of cellular immune responses in physiologic conditions and diseasesT cells are functionally not impaired in AML: increased PD-1 expression is only seen at time of relapse and correlates with a shift towards the memory T cell compartment.Tuberculosis Therapy Modifies the Cytokine Profile, Maturation State, and Expression of Inhibitory Molecules on Mycobacterium tuberculosis-Specific CD4+ T-Cells.CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART.Elevated Expression of CD160 and 2B4 Defines a Cytolytic HIV-Specific CD8+ T-Cell Population in Elite Controllers.Dual-Affinity Re-Targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cells.Increased memory differentiation is associated with decreased polyfunctionality for HIV but not for cytomegalovirus-specific CD8+ T cellsInduction of Inhibitory Receptors on T Cells During Plasmodium vivax Malaria Impairs Cytokine ProductionHIV-specific CD8+ T cells from elite controllers are primed for survival.Therapeutic vaccination expands and improves the function of the HIV-specific memory T-cell repertoire.Expression profiling of TCR-engineered T cells demonstrates overexpression of multiple inhibitory receptors in persisting lymphocytesSimultaneous TCR and CD244 signals induce dynamic downmodulation of CD244 on human antiviral T cells.Programed death-1/programed death-ligand 1 expression in lymph nodes of HIV infected patients: results of a pilot safety study in rhesus macaques using anti-programed death-ligand 1 (Avelumab).PD-L1 limits the mucosal CD8+ T cell response to Chlamydia trachomatis.
P2860
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P2860
Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Surface expression patterns of ...... ll exhaustion in HIV infection
@ast
Surface expression patterns of ...... ll exhaustion in HIV infection
@en
type
label
Surface expression patterns of ...... ll exhaustion in HIV infection
@ast
Surface expression patterns of ...... ll exhaustion in HIV infection
@en
prefLabel
Surface expression patterns of ...... ll exhaustion in HIV infection
@ast
Surface expression patterns of ...... ll exhaustion in HIV infection
@en
P2093
P2860
P50
P1433
P1476
Surface expression patterns of ...... ll exhaustion in HIV infection
@en
P2093
Constantinos Petrovas
Daniel C Douek
Emma Gostick
Joseph P Casazza
Mario Roederer
Martha Nason
Richard A Koup
Richard Haubrich
P2860
P304
P356
10.1182/BLOOD-2010-11-317297
P407
P577
2011-03-11T00:00:00Z