Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (CDK) inhibitor - Wikidata - awgldk - TriplyDB

Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (CDK) inhibitor

Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (CDK) inhibitor

http://www.wikidata.org/entity/Q35002806

about

Emergence of zebrafish models in oncology for validating novel anticancer drug targets and nanomaterials The Treatment of Cushing's Disease.Cyclin E-Mediated Human Proopiomelanocortin Regulation as a Therapeutic Target for Cushing Disease.Early embryonic androgen exposure induces transgenerational epigenetic and metabolic changes.Update on medical treatment for Cushing's disease.Loss-of-function mutations in the CABLES1 gene are a novel cause of Cushing's disease Zebrafish cancer: the state of the art and the path forward.Lycopene and beta-carotene induce growth inhibition and proapoptotic effects on ACTH-secreting pituitary adenoma cells.Pituitary tumors.EGFR as a therapeutic target for human, canine, and mouse ACTH-secreting pituitary adenomas.Solanum lyratum Extracts Induce Extrinsic and Intrinsic Pathways of Apoptosis in WEHI-3 Murine Leukemia Cells and Inhibit Allograft Tumor Animal models of pituitary neoplasia Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis.Pituitary Medicine From Discovery to Patient-Focused Outcomes.Hypoxia-inducible factor-1α (HIF-1α) promotes cap-dependent translation of selective mRNAs through up-regulating initiation factor eIF4E1 in breast cancer cells under hypoxia conditions Valproic acid shows a potent antitumor effect with alteration of DNA methylation in neuroblastoma Gene mutations in Cushing's disease.The role of genetic and epigenetic changes in pituitary tumorigenesis.New potential targets for treatment of Cushing's disease: epithelial growth factor receptor and cyclin-dependent kinases.Zebrafish xenotransplantation as a tool for in vivo cancer study.The promise of zebrafish as a chemical screening tool in cancer therapy.Recent progress of cyclin-dependent kinase inhibitors as potential anticancer agents.Currently used and investigational drugs for Cushing´s disease.Liver tumor models in transgenic zebrafish: an alternative in vivo approach to study hepatocarcinogenes.New targeted therapies in pituitary carcinoma resistant to temozolomide.The Basal NPO crh Fluctuation is Sustained Under Compromised Glucocorticoid Signaling in Diurnal Zebrafish.Zebrafish in Translational Cancer Research: Insight into Leukemia, Melanoma, Glioma and Endocrine Tumor Biology.E2F1-mediated human POMC expression in ectopic Cushing's syndrome.Histologic and Immunohistochemical Analyses of Soft Tissue Sarcomas From brca2-Mutant/ tp53-Mutant Zebrafish Are Consistent With Neural Crest (Schwann Cell) Origin.Zebrafish models for human cancer.P21Waf1/Cip1 and p27Kip1 are correlated with the development and invasion of prolactinoma.A zebrafish mosaic assay to study mammalian stem cells in real time in vivo.EGFR Induces E2F1-Mediated Corticotroph Tumorigenesis.Changes in PTTG1 by human TERT gene expression modulate the self-renewal of placenta-derived mesenchymal stem cells.Genetics of Cushing's Syndrome.Pituitary-Directed Therapies for Cushing's Disease.New Insights in Cushing Disease Treatment With Focus on a Derivative of Vitamin A.Endocrine Disorders A Simple Isomerization of the Purine Scaffold of a Kinase Inhibitor, Roscovitine, Affords a Four- to Seven-Fold Enhancement of Its Affinity for Four CDKs. Could This Be Traced Back to Conjugation-Induced Stiffenings/Loosenings of Rotational Barriers?Cell Cycle Regulators and Lineage-Specific Therapeutic Targets for Cushing Disease

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Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (CDK) inhibitor

http://www.wikidata.org/entity/Q35002806

description

2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

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PNAS.1018091108

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Proceedings of the National Academy of Sciences of the United States of America

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Targeting zebrafish and murine ...... pendent kinase (CDK) inhibitor

@en

P2093

Anat Ben-Shlomo

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Hong Jiang

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Kolja Wawrowsky

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Ning-Ai Liu

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Shlomo Melmed

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Shuo Lin

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Xue-Mo Fan

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P2860

Cell cycle, CDKs and cancer: a changing paradigm

Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase

Treatment of adrenocorticotropin-dependent Cushing's syndrome: a consensus statement.

Acromegaly pathogenesis and treatment

Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine

Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis

A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins

Isolation and characterization of a pituitary tumor-transforming gene (PTTG)

Tbx19, a tissue-selective regulator of POMC gene expression

HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomas

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8414-8419

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108

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21536883

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3100964

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