Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties - Wikidata - awgldk - TriplyDB

Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties

Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties

http://www.wikidata.org/entity/Q35006770

about

The fate of chemoresistance in triple negative breast cancer (TNBC)Aldehyde dehydrogenase as a marker and functional mediator of metastasis in solid tumors A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care Cancer Stem and Progenitor-Like Cells as Pharmacological Targets in Breast Cancer Treatment Nanomedicine-Mediated Therapies to Target Breast Cancer Stem Cells Chemotherapy targeting cancer stem cells Chemical biology drug sensitivity screen identifies sunitinib as synergistic agent with disulfiram in prostate cancer cells Disulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosis Disulfiram attenuates osteoclast differentiation in vitro: a potential antiresorptive agent Stemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment.Blocking the formation of radiation-induced breast cancer stem cells.Liposome encapsulated Disulfiram inhibits NFκB pathway and targets breast cancer stem cells in vitro and in vivo.High-throughput chemical screens identify disulfiram as an inhibitor of human glioblastoma stem cells.Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1)Disulfiram-induced cytotoxicity and endo-lysosomal sequestration of zinc in breast cancer cells.Concise review: bullseye: targeting cancer stem cells to improve the treatment of gliomas by repurposing disulfiram.Ovarian cancer stem cell markers: prognostic and therapeutic implications.Selective killing of gastric cancer cells by a small molecule targeting ROS-mediated ER stress activation.Zinc oxide nanoparticles selectively induce apoptosis in human cancer cells through reactive oxygen species.Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer.Radiosensitization by a novel Bcl-2 and Bcl-XL inhibitor S44563 in small-cell lung cancer.Disulfiram chelated with copper promotes apoptosis in human breast cancer cells by impairing the mitochondria functions.Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition.Metabolic activation of mitochondria in glioma stem cells promotes cancer development through a reactive oxygen species-mediated mechanism.Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation Disulfiram inhibits TGF-β-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-κB/Snail pathway.Mechanisms of chemoresistance in cancer stem cells.Identification and characterization of small molecule inhibitors of a plant homeodomain finger.EM23, A Natural Sesquiterpene Lactone from Elephantopus mollis, Induces Apoptosis in Human Myeloid Leukemia Cells through Thioredoxin- and Reactive Oxygen Species-Mediated Signaling Pathways.Delivery of disulfiram into breast cancer cells using folate-receptor-targeted PLGA-PEG nanoparticles: in vitro and in vivo investigations.Dithiocarbamate-based coordination compounds as potent proteasome inhibitors in human cancer cells.Yap1 promotes the survival and self-renewal of breast tumor initiating cells via inhibiting Smad3 signaling Disulfiram targets cancer stem-like cells and reverses resistance and cross-resistance in acquired paclitaxel-resistant triple-negative breast cancer cells.The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells.High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells: interaction with IQ motif-containing factors Low-dose triptolide in combination with idarubicin induces apoptosis in AML leukemic stem-like KG1a cell line by modulation of the intrinsic and extrinsic factors.Disulfiram eradicates tumor-initiating hepatocellular carcinoma cells in ROS-p38 MAPK pathway-dependent and -independent manners.Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells.Effective elimination of adult B-lineage acute lymphoblastic leukemia by disulfiram/copper complex in vitro and in vivo in patient-derived xenograft models.Poly lactic-co-glycolic acid controlled delivery of disulfiram to target liver cancer stem-like cells.

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Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties

http://www.wikidata.org/entity/Q35006770

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2011 nî lūn-bûn

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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2011 թվականի ապրիլին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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Disulfiram modulated ROS-MAPK ...... ncer stem cell-like properties

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Disulfiram modulated ROS-MAPK ...... ncer stem cell-like properties

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Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily

ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

ALDH3A1: a corneal crystallin with diverse functions

Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

Cancer stem cells: models and concepts

High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth.

TNFalpha up-regulates SLUG via the NF-kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell-like phenotype.

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