The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome.
about
Cwc24p is a general Saccharomyces cerevisiae splicing factor required for the stable U2 snRNP binding to primary transcriptsMolecular architecture of the human Prp19/CDC5L complexCwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centreFunctional organization of the Sm core in the crystal structure of human U1 snRNPCryoEM structures of two spliceosomal complexes: starter and dessert at the spliceosome feastsmFRET studies of the 'encounter' complexes and subsequent intermediate states that regulate the selectivity of ligand bindingRNA helicases in splicingNew insights into the spliceosome by single molecule fluorescence microscopyThe architecture of the spliceosomal U4/U6.U5 tri-snRNP.Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicingStructure of the yeast U2/U6 snRNA complexCrystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding proteinCooperative structure of the heterotrimeric pre-mRNA retention and splicing complexStructure and evolution of the spliceosomal peptidyl-prolyl cis-trans isomerase Cwc27Structure of a yeast spliceosome at 3.6-angstrom resolutionThe 3.8 Å structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysisCryo-EM structure of the spliceosome immediately after branchingSystematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.The DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome.Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly.Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS.Dynamic Contacts of U2, RES, Cwc25, Prp8 and Prp45 Proteins with the Pre-mRNA Branch-Site and 3' Splice Site during Catalytic Activation and Step 1 Catalysis in Yeast Spliceosomes.Rapid screening of yeast mutants with reporters identifies new splicing phenotypes.The G-patch protein Spp2 couples the spliceosome-stimulated ATPase activity of the DEAH-box protein Prp2 to catalytic activation of the spliceosomeMolecular dissection of step 2 catalysis of yeast pre-mRNA splicing investigated in a purified system.Structural and mechanistic insights into human splicing factor SF3b complex derived using an integrated approach guided by the cryo-EM density mapsThe 35S U5 snRNP Is Generated from the Activated Spliceosome during In vitro SplicingSingle-Molecule Pull-Down FRET to Dissect the Mechanisms of Biomolecular MachinesDisordered proteinaceous machinesThe nuclear cap-binding complex interacts with the U4/U6·U5 tri-snRNP and promotes spliceosome assembly in mammalian cellsSpliceosome Structure and FunctionIdentification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.Malleable ribonucleoprotein machine: protein intrinsic disorder in the Saccharomyces cerevisiae spliceosome.RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core.Workflow for Genome-Wide Determination of Pre-mRNA Splicing Efficiency from Yeast RNA-seq Data.A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing.Spliceosome discards intermediates via the DEAH box ATPase Prp43p.The pre-mRNA splicing machinery of trypanosomes: complex or simplified?Supraspliceosomes at defined functional states portray the pre-assembled nature of the pre-mRNA processing machine in the cell nucleus.Spliceosomal snRNA modifications and their function.
P2860
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P2860
The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome.
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The evolutionarily conserved c ...... step of the yeast spliceosome.
@ast
The evolutionarily conserved c ...... step of the yeast spliceosome.
@en
type
label
The evolutionarily conserved c ...... step of the yeast spliceosome.
@ast
The evolutionarily conserved c ...... step of the yeast spliceosome.
@en
prefLabel
The evolutionarily conserved c ...... step of the yeast spliceosome.
@ast
The evolutionarily conserved c ...... step of the yeast spliceosome.
@en
P2093
P1433
P1476
The evolutionarily conserved c ...... step of the yeast spliceosome.
@en
P2093
Henning Urlaub
Holger Stark
Julia Dannenberg
Patrizia Fabrizio
Prakash Dube
P304
P356
10.1016/J.MOLCEL.2009.09.040
P577
2009-11-01T00:00:00Z