Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment. - Wikidata - awgldk - TriplyDB

Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment.

Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment.

http://www.wikidata.org/entity/Q35023331

about

Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury Quantitative distribution and colocalization of non-muscle myosin light chain kinase isoforms and cortactin in human lung endothelium Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure.A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans Mechanisms regulating endothelial permeability Crosstalk between Inflammation and ROCK/MLCK Signaling Pathways in Gastrointestinal Disorders with Intestinal Hyperpermeability Regulation of myosin light chain kinase and telokin expression in smooth muscle tissues Angiopoietin-1 requires oxidant signaling through p47phox to promote endothelial barrier defense Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function The suppression of myosin light chain (MLC) phosphorylation during the response to lipopolysaccharide (LPS): beneficial or detrimental to endothelial barrier?Genetic polymorphisms associated with acute lung injury.Targeting protein kinases in central nervous system disorders Nonmuscle myosin light chain kinase regulates murine asthmatic inflammation Non-muscle Mlck is required for β-catenin- and FoxO1-dependent downregulation of Cldn5 in IL-1β-mediated barrier dysfunction in brain endothelial cells Chronic upregulation of activated microglia immunoreactive for galectin-3/Mac-2 and nerve growth factor following diffuse axonal injury.Myosin light chain kinase in microvascular endothelial barrier function.Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo Minozac treatment prevents increased seizure susceptibility in a mouse "two-hit" model of closed skull traumatic brain injury and electroconvulsive shock-induced seizures.Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury.Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration Albumin causes increased myosin light chain kinase expression in astrocytes via p38 mitogen-activated protein kinase.Myosin light chain kinase is involved in lipopolysaccharide-induced disruption of colonic epithelial barrier and bacterial translocation in rats.High concentrate diet induced mucosal injuries by enhancing epithelial apoptosis and inflammatory response in the hindgut of goats.Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application.Structure-Function Analysis of the Non-Muscle Myosin Light Chain Kinase (nmMLCK) Isoform by NMR Spectroscopy and Molecular Modeling: Influence of MYLK Variants Protection against endotoxic shock as a consequence of reduced nitrosative stress in MLCK210-null mice.Novel role for non-muscle myosin light chain kinase (MLCK) in hyperoxia-induced recruitment of cytoskeletal proteins, NADPH oxidase activation, and reactive oxygen species generation in lung endothelium.Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax.Myosin light chain kinase: pulling the strings of epithelial tight junction function TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation.Monocytes control second-phase neutrophil emigration in established lipopolysaccharide-induced murine lung injury.Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis Nonmuscle myosin light-chain kinase mediates microglial migration induced by HIV Tat: involvement of β1 integrins.Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins.Nonmuscle myosin light chain kinase activity modulates radiation-induced lung injury.Myosin light chain kinase signaling in endothelial barrier dysfunction.Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury.Making genomics functional: deciphering the genetics of acute lung injury.Inhibition of Myosin light-chain kinase attenuates cerebral edema after traumatic brain injury in postnatal mice.

P2860

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P2860

Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment.

http://www.wikidata.org/entity/Q35023331

description

2003 nî lūn-bûn

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2003 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2003 թվականի մայիսին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Protein kinase involved in lun ...... d in vivo inhibitor treatment.

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Protein kinase involved in lun ...... d in vivo inhibitor treatment.

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type

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Protein kinase involved in lun ...... d in vivo inhibitor treatment.

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Protein kinase involved in lun ...... d in vivo inhibitor treatment.

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Protein kinase involved in lun ...... d in vivo inhibitor treatment.

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Protein kinase involved in lun ...... d in vivo inhibitor treatment.

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PNAS.1031595100

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Protein kinase involved in lun ...... d in vivo inhibitor treatment.

@en

P2093

Anastasia V Velentza

http://www.w3.org/2001/XMLSchema#string

David Steinhorn

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Jacques Haiech

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James Schavocky

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Janet Rossi

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Linda J Van Eldik

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Magdalena Zasadzki

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Mark S Wainwright

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Susan Crawford

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Vladimir Shirinsky

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P2860

Initial sequencing and comparative analysis of the mouse genome

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene

The druggable genome

Efficacy and safety of recombinant human activated protein C for severe sepsis

Ligand modulation of glial activation: cell permeable, small molecule inhibitors of serine-threonine protein kinases can block induction of interleukin 1 beta and nitric oxide synthase II.

A protein kinase associated with apoptosis and tumor suppression: structure, activity, and discovery of peptide substrates.

Mechanisms regulating endothelial cell barrier function.

Advances in mechanical ventilation.

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6233-6238

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scholarly article

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10.1073/PNAS.1031595100

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10

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100

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Daniel Watterson

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2003-05-02T00:00:00Z

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10775633

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12730364

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156355

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