Follicle-stimulating hormone activates extracellular signal-regulated kinase but not extracellular signal-regulated kinase kinase through a 100-kDa phosphotyrosine phosphatase
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Follicle-stimulating hormone (FSH) activates extracellular signal-regulated kinase phosphorylation independently of beta-arrestin- and dynamin-mediated FSH receptor internalizationAPPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complexEmerging roles for the FSH receptor adapter protein APPL1 and overlap of a putative 14-3-3τ interaction domain with a canonical G-protein interaction siteRole of the Extracellular and Intracellular Loops of Follicle-Stimulating Hormone Receptor in Its FunctionThe Interplay between Circadian System, Cholesterol Synthesis, and Steroidogenesis Affects Various Aspects of Female ReproductionFSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cellsExtracellular Signal-regulated Kinase (ERK)-dependent Phosphorylation of Y-Box-binding Protein 1 (YB-1) Enhances Gene Expression in Granulosa Cells in Response to Follicle-stimulating Hormone (FSH)CCAAT/enhancer-binding proteins (C/EBP)-α and -β are essential for ovulation, luteinization, and the expression of key target genesThe TATA binding protein associated factor 4b (TAF4b) mediates FSH stimulation of the IGFBP-3 promoter in cultured porcine ovarian granulosa cells.Activation of the lutropin/choriogonadotropin receptor in MA-10 cells stimulates tyrosine kinase cascades that activate ras and the extracellular signal regulated kinases (ERK1/2).Human follicle-stimulating hormone (FSH) receptor interacts with the adaptor protein APPL1 in HEK 293 cells: potential involvement of the PI3K pathway in FSH signaling.Transactivation of the epidermal growth factor receptor is involved in the lutropin receptor-mediated down-regulation of ovarian aromatase expression in vivo.Integrating microRNAs into the complexity of gonadotropin signaling networksInvolvement of FoxO1 in the effects of follicle-stimulating hormone on inhibition of apoptosis in mouse granulosa cellsThe adapter protein APPL1 links FSH receptor to inositol 1,4,5-trisphosphate production and is implicated in intracellular Ca(2+) mobilizationFSH signaling pathways in immature granulosa cells that regulate target gene expression: branching out from protein kinase A.Induction of cyclin D2 in rat granulosa cells requires FSH-dependent relief from FOXO1 repression coupled with positive signals from SmadNeuronal microtubule-associated protein 2D is a dual a-kinase anchoring protein expressed in rat ovarian granulosa cells.A delayed gonadotropin-dependent and growth factor-mediated activation of the extracellular signal-regulated kinase 1/2 cascade negatively regulates aromatase expression in granulosa cells.Inhibition of follicle-stimulating hormone-induced preovulatory follicles in rats treated with a nonsteroidal negative allosteric modulator of follicle-stimulating hormone receptor.AMPK activation by dihydrotestosterone reduces FSH-stimulated cell proliferation in rat granulosa cells by inhibiting ERK signaling pathway.Mapping the follicle-stimulating hormone-induced signaling networks.Selective expression of KrasG12D in granulosa cells of the mouse ovary causes defects in follicle development and ovulationMutations of the lutropin/choriogonadotropin receptor that do not activate the phosphoinositide cascade allow hCG to induce aromatase expression in immature rat granulosa cellsIGF-I signaling is essential for FSH stimulation of AKT and steroidogenic genes in granulosa cells.Molecular mechanisms of ovulation: co-ordination through the cumulus complex.Insulin Receptor Substrate 1, the Hub Linking Follicle-stimulating Hormone to Phosphatidylinositol 3-Kinase ActivationThe luteinizing hormone receptor-activated extracellularly regulated kinase-1/2 cascade stimulates epiregulin release from granulosa cellsProtein Kinase A: A Master Kinase of Granulosa Cell DifferentiationRole of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target vascular endothelial growth factor in ovarian granulosa cells in response to folFunctions of Fyn kinase in the completion of meiosis in mouse oocytes.Characterization of the gonadotropin releasing hormone receptor (GnRHR) expression and activity in the female mouse ovary.Constitutively active protein kinase A qualitatively mimics the effects of follicle-stimulating hormone on granulosa cell differentiation.Prohibitin regulates the FSH signaling pathway in rat granulosa cell differentiation.Modulation of expression of 17-Hydroxylase/17,20 lyase (CYP17) and P450 aromatase (CYP19) by inhibition of MEK1 in a human ovarian granulosa-like tumor cell line.The Follitropin Receptor: Matching Structure and Function.Amplification of FSH signaling by CFTR and nuclear soluble adenylyl cyclase in the ovary.Follicle-Stimulating Hormone (FSH)-dependent Regulation of Extracellular Regulated Kinase (ERK) Phosphorylation by the Mitogen-activated Protein (MAP) Kinase Phosphatase MKP3.HCG-mediated activation of mTORC1 signaling plays a crucial role in steroidogenesis in human granulosa lutein cells.Hexabromocyclododecane facilitates FSH activation of ERK1/2 and AKT through epidermal growth factor receptor in rat granulosa cells.
P2860
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P2860
Follicle-stimulating hormone activates extracellular signal-regulated kinase but not extracellular signal-regulated kinase kinase through a 100-kDa phosphotyrosine phosphatase
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Follicle-stimulating hormone a ...... Da phosphotyrosine phosphatase
@ast
Follicle-stimulating hormone a ...... Da phosphotyrosine phosphatase
@en
type
label
Follicle-stimulating hormone a ...... Da phosphotyrosine phosphatase
@ast
Follicle-stimulating hormone a ...... Da phosphotyrosine phosphatase
@en
prefLabel
Follicle-stimulating hormone a ...... Da phosphotyrosine phosphatase
@ast
Follicle-stimulating hormone a ...... Da phosphotyrosine phosphatase
@en
P2093
P2860
P356
P1476
Follicle-stimulating hormone a ...... Da phosphotyrosine phosphatase
@en
P2093
Daniel W Carr
Evelyn T Maizels
Hisaaki Kawakatsu
Johannes W Hell
Joshua Cottom
Lisa M Salvador
Mary Hunzicker-Dunn
Masato Ogata
Monika A Davare
Scott Reierstad
P2860
P304
P356
10.1074/JBC.M203901200
P407
P50
P577
2002-12-18T00:00:00Z