Human follicle-stimulating hormone (FSH) receptor interacts with the adaptor protein APPL1 in HEK 293 cells: potential involvement of the PI3K pathway in FSH signaling.
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The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocationAPPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complexEmerging roles for the FSH receptor adapter protein APPL1 and overlap of a putative 14-3-3τ interaction domain with a canonical G-protein interaction siteA role of the Lowe syndrome protein OCRL in early steps of the endocytic pathwayRole of the Extracellular and Intracellular Loops of Follicle-Stimulating Hormone Receptor in Its FunctionAPPL proteins FRET at the BAR: direct observation of APPL1 and APPL2 BAR domain-mediated interactions on cell membranes using FRET microscopyMembrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides.Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cellsAppl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblastsIdentification of phosphorylation sites within the signaling adaptor APPL1 by mass spectrometry.The combined therapy myo-inositol plus D-chiro-inositol, rather than D-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial.The differential effects of the gonadotropin receptors on aromatase expression in primary cultures of immature rat granulosa cells are highly dependent on the density of receptors expressed and the activation of the inositol phosphate cascade.Integrating microRNAs into the complexity of gonadotropin signaling networksAn APPL1/Akt signaling complex regulates dendritic spine and synapse formation in hippocampal neuronsThe adapter protein APPL1 links FSH receptor to inositol 1,4,5-trisphosphate production and is implicated in intracellular Ca(2+) mobilizationIncreased abundance of the adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif (APPL1) in patients with obesity and type 2 diabetes: evidence for altered adiponectin signalling.APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor.APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice.Role of the intracellular domains of the human FSH receptor in G(alphaS) protein coupling and receptor expressionThe endosomal adaptor protein APPL1 impairs the turnover of leading edge adhesions to regulate cell migration.Mapping the follicle-stimulating hormone-induced signaling networks.Downregulation of adiponectin system in granulosa cells and low levels of HMW adiponectin in PCOS.Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts.Multifunctional protein APPL2 contributes to survival of human glioma cells.G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis.APPL1: role in adiponectin signaling and beyondNovel pathways in gonadotropin receptor signaling and biased agonism.Are circulating gonadotropin isoforms naturally occurring biased agonists? Basic and therapeutic implications.The Follitropin Receptor: Matching Structure and Function.APPL1 is a multifunctional endosomal signaling adaptor protein.Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex.Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment.Molecular Regulation of Follicle-Stimulating Hormone Synthesis, Secretion and Action.Intracellular Follicle-Stimulating Hormone Receptor Trafficking and Signaling
P2860
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P2860
Human follicle-stimulating hormone (FSH) receptor interacts with the adaptor protein APPL1 in HEK 293 cells: potential involvement of the PI3K pathway in FSH signaling.
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2004 nî lūn-bûn
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2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2004 թվականի ապրիլին հրատարակված գիտական հոդված
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2004年の論文
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2004年学术文章
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name
Human follicle-stimulating hor ...... PI3K pathway in FSH signaling.
@ast
Human follicle-stimulating hor ...... PI3K pathway in FSH signaling.
@en
type
label
Human follicle-stimulating hor ...... PI3K pathway in FSH signaling.
@ast
Human follicle-stimulating hor ...... PI3K pathway in FSH signaling.
@en
prefLabel
Human follicle-stimulating hor ...... PI3K pathway in FSH signaling.
@ast
Human follicle-stimulating hor ...... PI3K pathway in FSH signaling.
@en
P2093
P2860
P1476
Human follicle-stimulating hor ...... PI3K pathway in FSH signaling.
@en
P2093
Brian D Cohen
Cheryl A Nechamen
Giselles Acevedo
James A Dias
Joseph R Testa
Poulikos I Poulikakos
Richard M Thomas
P2860
P304
P356
10.1095/BIOLREPROD.103.025833
P407
P577
2004-04-07T00:00:00Z