Genetic and pharmacologic inhibition of the Ca2+ influx channel TRPC3 protects secretory epithelia from Ca2+-dependent toxicity. - Wikidata - awgldk - TriplyDB

Genetic and pharmacologic inhibition of the Ca2+ influx channel TRPC3 protects secretory epithelia from Ca2+-dependent toxicity.

Genetic and pharmacologic inhibition of the Ca2+ influx channel TRPC3 protects secretory epithelia from Ca2+-dependent toxicity.

http://www.wikidata.org/entity/Q35028058

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Ca2+ toxicity and mitochondrial damage in acute pancreatitis: translational overview The role of Ca2+ in the pathophysiology of pancreatitis Ca²⁺ signaling and regulation of fluid secretion in salivary gland acinar cells.The Role of Transient Receptor Potential Channel 6 Channels in the Pulmonary Vasculature Risk factors for pancreatic cancer: underlying mechanisms and potential targets.The role of Ca2+ influx in endocytic vacuole formation in pancreatic acinar cells Redox signaling in acute pancreatitis.The ER/PM microdomain, PI(4,5)P₂ and the regulation of STIM1-Orai1 channel function.Autophagy and pancreatitis Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin.Orai1 and STIM1 in ER/PM junctions: roles in pancreatic cell function and dysfunction Cluster of differentiation 38 (CD38) mediates bile acid-induced acinar cell injury and pancreatitis through cyclic ADP-ribose and intracellular calcium release Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy.Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ release.Fusion of lysosomes with secretory organelles leads to uncontrolled exocytosis in the lysosomal storage disease mucolipidosis type IV.Brain-derived neurotrophic factor in the airways.In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels -- mirage or pot of gold?Molecular pharmacology of store-operated CRAC channels.Pancreatic adaptive responses in alcohol abuse: Role of the unfolded protein response.From GTP and G proteins to TRPC channels: a personal account.Adenosine A1 receptor-operated calcium entry in renal afferent arterioles is dependent on postnatal maturation of TRPC3 channels.Functional role of TRP channels in modulating ER stress and Autophagy.Pathophysiological mechanisms in acute pancreatitis: Current understanding.Pharmacological evidence for a role of the transient receptor potential canonical 3 (TRPC3) channel in endoplasmic reticulum stress-induced apoptosis of human coronary artery endothelial cells.Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways.Regulation of Endoplasmic Reticulum-Mitochondria Ca2+ Transfer and Its Importance for Anti-Cancer Therapies Decreased levels of canonical transient receptor potential channel 3 protein in the rat cerebral cortex after chronic treatment with lithium or valproate.Brain-derived neurotrophic factor (BDNF) induces sustained intracellular Ca2+ elevation through the up-regulation of surface transient receptor potential 3 (TRPC3) channels in rodent microglia.TRPC3 regulates release of brain-derived neurotrophic factor from human airway smooth muscle.SOCE induced calcium overload regulates autophagy in acute pancreatitis via calcineurin activation.TRPC3 channel confers cerebrovascular remodelling during hypertension via transactivation of EGF receptor signalling.An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel.Increased store-operated Ca2+ entry mediated by GNB5 and STIM1.Intracellular rupture, exocytosis and actin interaction of endocytic vacuoles in pancreatic acinar cells: initiating events in acute pancreatitis.

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P2860

Genetic and pharmacologic inhibition of the Ca2+ influx channel TRPC3 protects secretory epithelia from Ca2+-dependent toxicity.

http://www.wikidata.org/entity/Q35028058

description

2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年學術文章

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Genetic and pharmacologic inhi ...... from Ca2+-dependent toxicity.

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Genetic and pharmacologic inhi ...... from Ca2+-dependent toxicity.

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type

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Genetic and pharmacologic inhi ...... from Ca2+-dependent toxicity.

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Genetic and pharmacologic inhi ...... from Ca2+-dependent toxicity.

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Genetic and pharmacologic inhi ...... from Ca2+-dependent toxicity.

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Genetic and pharmacologic inhi ...... from Ca2+-dependent toxicity.

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J.GASTRO.2011.02.052

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Genetic and pharmacologic inhi ...... a from Ca2+-dependent toxicity

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Dongki Yang

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Joel Abramowitz

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Kyu Pil Lee

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Lutz Birnbaumer

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Min Seuk Kim

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Shmuel Muallem

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Yasuo Mori

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P2860

STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels

Transient receptor potential cation channels in disease

Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice

Calcium signalling: dynamics, homeostasis and remodelling

Store-operated calcium channels

Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells.

Emerging new pathways of pathogenesis and targets for treatment in systemic lupus erythematosus and Sjogren's syndrome.

Preventing Ca2+-mediated nitrosative stress in neurodegenerative diseases: possible pharmacological strategies.

Cellular stress/the unfolded protein response: relevance to sleep and sleep disorders.

Polarized but differential localization and recruitment of STIM1, Orai1 and TRPC channels in secretory cells.

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10.1053/J.GASTRO.2011.02.052

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