Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways.
about
Transient receptor potential (TRP) channels: a clinical perspectiveMICU1 drives glycolysis and chemoresistance in ovarian cancer.Non-selective cation channels mediate chloroquine-induced relaxation in precontracted mouse airway smooth muscleStore-operated Ca2+ entry does not control proliferation in primary cultures of human metastatic renal cellular carcinoma.Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarctionReduced endoplasmic reticulum stress-induced apoptosis and impaired unfolded protein response in TRPC3-deficient M1 macrophages.Transient receptor potential canonical type 3 channels control the vascular contractility of mouse mesenteric arteries.Relaxant action of plumula nelumbinis extract on mouse airway smooth muscleThe involvement of TRPC3 channels in sinoatrial arrhythmiasIdentification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channelsDefective Store-Operated Calcium Entry Causes Partial Nephrogenic Diabetes InsipidusCalcium and adenosine triphosphate control of cellular pathology: asparaginase-induced pancreatitis elicited via protease-activated receptor 2Potent analgesic effects of a store-operated calcium channel inhibitor.Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain.Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy.Molecular determinants mediating gating of Transient Receptor Potential Canonical (TRPC) channels by stromal interaction molecule 1 (STIM1).Respiratory allergies: a general overview of remedies, delivery systems, and the need to progressIn pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels -- mirage or pot of gold?Molecular pharmacology of store-operated CRAC channels.Adenosine A1 receptor-operated calcium entry in renal afferent arterioles is dependent on postnatal maturation of TRPC3 channels.Pharmacological evidence for a role of the transient receptor potential canonical 3 (TRPC3) channel in endoplasmic reticulum stress-induced apoptosis of human coronary artery endothelial cells.Store-operated CRAC channel inhibitors: opportunities and challenges.Targeting calcium signaling in cancer therapy.Canonical Transient Receptor Potential Channels and Their Link with Cardio/Cerebro-Vascular Diseases.Differences in TRPC3 and TRPC6 channels assembly in mesenteric vascular smooth muscle cells in essential hypertension.Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels.TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy.TRPC6 regulates cell cycle progression by modulating membrane potential in bone marrow stromal cells.Endothelin-1 and endothelin-2 initiate and maintain contractile responses by different mechanisms in rat mesenteric and cerebral arteriesHydrogen peroxide activates store-operated Ca(2+) entry in coronary arteries.Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca2+ entry pathway.A background Ca2+ entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling.Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors.TRPC1- and TRPC3-dependent Ca2+ signaling in mouse cortical astrocytes affects injury-evoked astrogliosis in vivo.Polygonum aviculare L. extract and quercetin attenuate contraction in airway smooth muscle.Structure-activity relationship study and discovery of indazole 3-carboxamides as calcium-release activated calcium channel blockers.TRPC3 channel confers cerebrovascular remodelling during hypertension via transactivation of EGF receptor signalling.SUR1-TRPM4 channel activation and phasic secretion of MMP-9 induced by tPA in brain endothelial cells.Structure-function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating
P2860
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P2860
Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Novel pyrazole compounds for p ...... operated and store-operated Ca
@nl
Novel pyrazole compounds for p ...... erated Ca(2+) entry pathways.
@en
type
label
Novel pyrazole compounds for p ...... operated and store-operated Ca
@nl
Novel pyrazole compounds for p ...... erated Ca(2+) entry pathways.
@en
prefLabel
Novel pyrazole compounds for p ...... operated and store-operated Ca
@nl
Novel pyrazole compounds for p ...... erated Ca(2+) entry pathways.
@en
P2093
P2860
P50
P1476
Novel pyrazole compounds for p ...... perated Ca(2+) entry pathways
@en
P2093
B Doleschal
H Schleifer
I Frischauf
M Lichtenegger
R Oppenrieder
T N Glasnov
P2860
P304
P356
10.1111/J.1476-5381.2012.02126.X
P407
P577
2012-12-01T00:00:00Z