Functionalized congeners of A3 adenosine receptor-selective nucleosides containing a bicyclo[3.1.0]hexane ring system.
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The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRsPurine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3 Adenosine Receptor Agonists.Polyamidoamine (PAMAM) dendrimer conjugate specifically activates the A3 adenosine receptor to improve post-ischemic/reperfusion function in isolated mouse hearts.Synthesis and pharmacological characterization of [(125)I]MRS5127, a high affinity, selective agonist radioligand for the A3 adenosine receptor2-Dialkynyl derivatives of (N)-methanocarba nucleosides: 'Clickable' A(3) adenosine receptor-selective agonists.Polyamidoamine (PAMAM) dendrimer conjugates of "clickable" agonists of the A3 adenosine receptor and coactivation of the P2Y14 receptor by a tethered nucleotide.Novel Alexa Fluor-488 labeled antagonist of the A(2A) adenosine receptor: Application to a fluorescence polarization-based receptor binding assay.Synthesis and biological evaluation of 2',4'- and 3',4'-bridged nucleoside analogues.Predicted structures of agonist and antagonist bound complexes of adenosine A3 receptorTruncated (N)-Methanocarba Nucleosides as A(1) Adenosine Receptor Agonists and Partial Agonists: Overcoming Lack of a Recognition ElementPharmacological and therapeutic effects of A3 adenosine receptor agonistsClick modification in the N6 region of A3 adenosine receptor-selective carbocyclic nucleosides for dendrimeric tethering that preserves pharmacophore recognition.Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.Lighting up G protein-coupled purinergic receptors with engineered fluorescent ligands.Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activityTruncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane SubstitutionsFluorescent ligands for adenosine receptors.Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor.Synthesis and anti-renal fibrosis activity of conformationally locked truncated 2-hexynyl-N(6)-substituted-(N)-methanocarba-nucleosides as A3 adenosine receptor antagonists and partial agonists.The A3 adenosine receptor as multifaceted therapeutic target: pharmacology, medicinal chemistry, and in silico approaches.A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy.Recent Advances in the Synthesis of Carbocyclic Nucleosides via Ring-Closing MetathesisRepurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists
P2860
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P2860
Functionalized congeners of A3 adenosine receptor-selective nucleosides containing a bicyclo[3.1.0]hexane ring system.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Functionalized congeners of A3 ...... yclo[3.1.0]hexane ring system.
@ast
Functionalized congeners of A3 ...... yclo[3.1.0]hexane ring system.
@en
type
label
Functionalized congeners of A3 ...... yclo[3.1.0]hexane ring system.
@ast
Functionalized congeners of A3 ...... yclo[3.1.0]hexane ring system.
@en
prefLabel
Functionalized congeners of A3 ...... yclo[3.1.0]hexane ring system.
@ast
Functionalized congeners of A3 ...... yclo[3.1.0]hexane ring system.
@en
P2093
P2860
P50
P356
P1476
Functionalized congeners of A3 ...... cyclo[3.1.0]hexane ring system
@en
P2093
Andrei A Ivanov
Athena M Klutz
Moshe Chinn
P2860
P304
P356
10.1021/JM900426G
P407
P577
2009-12-01T00:00:00Z