Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity
about
Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a.Structural probing of off-target G protein-coupled receptor activities within a series of adenosine/adenine congenersThe role of experimental and computational structural approaches in 7TM drug discovery.Nitrobenzylthioinosine mimics adenosine to attenuate the epileptiform discharge of hippocampal neurons from epileptic rats.Probing biased/partial agonism at the G protein-coupled A(2B) adenosine receptor.Photomodulation of G protein-coupled adenosine receptors by a novel light-switchable ligandPurinergic system dysfunction in mood disorders: a key target for developing improved therapeutics.Structure-based approaches to ligands for G-protein-coupled adenosine and P2Y receptors, from small molecules to nanoconjugates.John Daly Lecture: Structure-guided Drug Design for Adenosine and P2Y ReceptorsMethanocarba ring as a ribose modification in ligands of G protein-coupled purine and pyrimidine receptors: synthetic approaches.Medicinal chemistry of adenosine, P2Y and P2X receptors.Rigid Adenine Nucleoside Derivatives as Novel Modulators of the Human Sodium Symporters for Dopamine and Norepinephrine.Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain.Crystal structures of the A2A adenosine receptor and their use in medicinal chemistry.X-ray structural information of GPCRs in drug design: what are the limitations and where do we go?Adenosine receptors and epilepsy: current evidence and future potential.Hypothermia in mouse is caused by adenosine A1 and A3 receptor agonists and AMP via three distinct mechanisms.South (S)- and North (N)-Methanocarba-7-Deazaadenosine Analogues as Inhibitors of Human Adenosine Kinase.Breakthrough in GPCR Crystallography and Its Impact on Computer-Aided Drug Design.Validation of a Preclinical Drug Screening Platform for Pharmacoresistant Epilepsy.Structure-Based Scaffold Repurposing for G Protein-Coupled Receptors: Transformation of Adenosine Derivatives into 5HT2B/5HT2C Serotonin Receptor Antagonists.Recent Advances in the Synthesis of Carbocyclic Nucleosides via Ring-Closing Metathesis
P2860
Q27305254-F4E4207E-A6C8-42A7-87E8-6FC71F803FA7Q28539094-DB966CE8-2DDA-4416-85AD-0D1181A716A0Q30377191-700204B8-486A-42C6-B513-A17EEA22CF91Q33829228-A84342BA-89F6-435C-91FC-B45D653C31EFQ34027829-BAFE41E2-414E-4EC9-A5BD-703569159050Q34343552-49AC66AF-B963-4B0D-998E-A141BEE3E9CAQ34674792-F7A4B1A0-2C23-4755-B196-B52E3BA6857FQ34676680-2C78E779-4438-4947-A8FA-AEE5A4296646Q35580301-BEC521AA-9F4E-43A3-B266-C18F18A1DB99Q35825817-7D887A65-7020-4205-948A-48C9E212240CQ35873582-DFE884C9-E9DB-40F5-8B88-4C908F8B8F56Q36733500-F9BA3777-D05E-4B66-9DEE-A59856D0DE6BQ37381136-6C926073-671D-4474-8B80-95ABBBAC7D98Q37641728-91102D06-C542-4B0B-8725-84310EB0B360Q38093833-4EC3EF7B-5488-414A-80E3-4DB32DBA46CAQ38245140-9B5D13E9-5A05-4F50-88CD-2D5EC650B76AQ39133269-53F62179-CAED-4C42-93E7-ABA7843E67DFQ41153115-3A5B4016-6DA4-4F43-A4AD-AA4E69B1ABE2Q47348749-90C85793-9BA7-42DC-8B9D-81C969FF34C4Q47416325-2DFC6607-5414-4C42-983F-78002994681DQ48172109-6A6969D0-E54A-47B9-8F54-976A0AA5682FQ56864676-760AF8CC-CFB2-4888-AB61-FDE2F0D05C90
P2860
Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Structural sweet spot for A1 a ...... potent anticonvulsant activity
@ast
Structural sweet spot for A1 a ...... potent anticonvulsant activity
@en
type
label
Structural sweet spot for A1 a ...... potent anticonvulsant activity
@ast
Structural sweet spot for A1 a ...... potent anticonvulsant activity
@en
prefLabel
Structural sweet spot for A1 a ...... potent anticonvulsant activity
@ast
Structural sweet spot for A1 a ...... potent anticonvulsant activity
@en
P2093
P2860
P50
P356
P1476
Structural sweet spot for A1 a ...... potent anticonvulsant activity
@en
P2093
Francesca Deflorian
Steven M Moss
Xiaohui Jiang
P2860
P304
P356
10.1021/JM300965A
P407
P577
2012-09-10T00:00:00Z