Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques - Wikidata - awgldk - TriplyDB

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

http://www.wikidata.org/entity/Q35030015

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G Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRs The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease Microglia communication: Parallels between aging and Alzheimer's disease Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology.Amelioration of amyloid-β-induced deficits by DcR3 in an Alzheimer's disease model.Protein-Induced Pluripotent Stem Cells Ameliorate Cognitive Dysfunction and Reduce Aβ Deposition in a Mouse Model of Alzheimer's Disease.New insights on the role of microglia in synaptic pruning in health and disease Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer's Disease.Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques Imaging robust microglial activation after lipopolysaccharide administration in humans with PET.GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP.Attenuation of β-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology.High-resolution analytical imaging and electron holography of magnetite particles in amyloid cores of Alzheimer's disease.TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques.Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans.Imaging hydrogen peroxide in Alzheimer's disease via cascade signal amplification Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration.Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-β Protein Precursor Transgenic Mice TREM2 in Neurodegenerative Diseases.Inflammation in Alzheimer's disease: Lessons learned from microglia-depletion models.Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.Physiological roles of macrophages.Clearance of cerebral Aβ in Alzheimer's disease: reassessing the role of microglia and monocytes.The IL-1β phenomena in neuroinflammatory diseases.Aging Microglia-Phenotypes, Functions and Implications for Age-Related Neurodegenerative Diseases Autophagy is involved in oral rAAV/Aβ vaccine-induced Aβ clearance in APP/PS1 transgenic mice.Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer's disease.Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.Oxalate-curcumin-based probe for micro- and macroimaging of reactive oxygen species in Alzheimer's disease.Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging.Human Induced Pluripotent Stem Cells and the Modelling of Alzheimer's Disease: The Human Brain Outside the Dish.Practical considerations for choosing a mouse model of Alzheimer's disease.Axonal and myelinic pathology in 5xFAD Alzheimer's mouse spinal cord.Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease.Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice.Functional and structural damage of neurons by innate immune mechanisms during neurodegeneration.Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1.

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Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

http://www.wikidata.org/entity/Q35030015

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2015 nî lūn-bûn

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2015 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2015 թվականի հունվարին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年论文

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Microglia constitute a barrier ...... r Aβ42 hotspots around plaques

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Microglia constitute a barrier ...... r Aβ42 hotspots around plaques

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Microglia constitute a barrier ...... r Aβ42 hotspots around plaques

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Microglia constitute a barrier ...... r Aβ42 hotspots around plaques

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Microglia constitute a barrier ...... r Aβ42 hotspots around plaques

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Nature Communications

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Microglia constitute a barrier ...... r Aβ42 hotspots around plaques

@en

P2093

Aaron Schain

http://www.w3.org/2001/XMLSchema#string

Carlo Condello

http://www.w3.org/2001/XMLSchema#string

Jaime Grutzendler

http://www.w3.org/2001/XMLSchema#string

Peng Yuan

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TREM2 Variants in Alzheimer's Disease

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

The pathobiology of vascular dementia

Synaptotoxicity of Alzheimer beta amyloid can be explained by its membrane perforating property

Microglia: active sensor and versatile effector cells in the normal and pathologic brain

ATP mediates rapid microglial response to local brain injury in vivo

The blood-brain barrier in health and chronic neurodegenerative disorders

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo

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6176

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10.1038/NCOMMS7176

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6

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271597500

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25630253

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4311408

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