Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension - Wikidata - awgldk - TriplyDB

Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension

Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension

http://www.wikidata.org/entity/Q35040806

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Epigenetic modulation as a therapeutic approach for pulmonary arterial hypertension Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system Targeting the Wnt signaling pathways in pulmonary arterial hypertension Apelin-APJ signaling: a potential therapeutic target for pulmonary arterial hypertension The emerging role of epigenetics in pulmonary arterial hypertension: an important avenue for clinical trials (2015 Grover Conference Series)Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects.Regulation of the Apelinergic System and Its Potential in Cardiovascular Disease: Peptides and Small Molecules as Tools for Discovery.Therapeutic implications of microRNAs in pulmonary arterial hypertension.An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension The myriad essential roles of microRNAs in cardiovascular homeostasis and disease.Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension.Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival MicroRNAs in pulmonary arterial hypertension.Apelin and pulmonary hypertension.Genetic differences and aberrant methylation in the apelin system predict the risk of high-altitude pulmonary edema.Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling.Mechanisms of dysfunction in senescent pulmonary endothelium.Role of reactive oxygen and nitrogen species in the vascular responses to inflammation.Connectivity map analysis of nonsense-mediated decay-positive BMPR2-related hereditary pulmonary arterial hypertension provides insights into disease penetrance.Identification of Biomarkers for Schistosoma-Associated Pulmonary Arterial Hypertension Based on RNA-Seq Data of Mouse Whole Lung Tissues.Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report.In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target Slug The Endothelial Prolyl-4-Hydroxylase Domain 2/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in Mice.FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development MicroRNAs in pulmonary arterial remodeling Biased G Protein-Coupled Receptor Signaling: New Player in Modulating Physiology and Pathology Endothelium as a gatekeeper of fatty acid transport.[Pyr1]Apelin-13(1-12) Is a Biologically Active ACE2 Metabolite of the Endogenous Cardiovascular Peptide [Pyr1]Apelin-13.Anticipated classes of new medications and molecular targets for pulmonary arterial hypertension Molecular biology of atherosclerosis.Lungs at high-altitude: genomic insights into hypoxic responses.Agonist-induced internalization and desensitization of the apelin receptor.Modulation of Endothelial Bone Morphogenetic Protein Receptor Type 2 Activity by Vascular Endothelial Growth Factor Receptor 3 in Pulmonary Arterial Hypertension.Suppression of endothelial CD39/ENTPD1 is associated with pulmonary vascular remodeling in pulmonary arterial hypertension.Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin.Discovery of a murine model of clinical PAH: Mission impossible?Advances in treatment of pulmonary arterial hypertension: patent review.

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Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension

http://www.wikidata.org/entity/Q35040806

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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2011 թվականի հունվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension

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Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension

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Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension

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Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension

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Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension

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Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension

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ATVBAHA.110.219980

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Arteriosclerosis, Thrombosis, and Vascular Biology

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Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension

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Hedi Razavi

http://www.w3.org/2001/XMLSchema#string

Hyung J Chun

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Jongmin Kim

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Ramendra K Kundu

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Rani Agrawal

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Roham T Zamanian

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Suparna M Chandra

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Vinicio de Jesus Perez

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P2860

Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum

Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

Distribution of mRNA encoding B78/apj, the rat homologue of the human APJ receptor, and its endogenous ligand apelin in brain and peripheral tissues

Characterization of apelin, the ligand for the APJ receptor

Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension

Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility

Apelin stimulates glucose utilization in normal and obese insulin-resistant mice

Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin

Venous dilator effect of apelin, an endogenous peptide ligand for the orphan APJ receptor, in conscious rats

Defective lung vascular development and fatal respiratory distress in endothelial NO synthase-deficient mice: a model of alveolar capillary dysplasia?

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814-820

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10.1161/ATVBAHA.110.219980

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Thomas Quertermous

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2011-01-13T00:00:00Z

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21233449

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