Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis - Wikidata - awgldk - TriplyDB

Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

http://www.wikidata.org/entity/Q24657323

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MicroRNA-21 blocks abdominal aortic aneurysm development and nicotine-augmented expansion MicroRNA-26a is a novel regulator of vascular smooth muscle cell function Receptor heteromerization and drug discovery.Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system Apelin-APJ signaling: a potential therapeutic target for pulmonary arterial hypertension In vivo modulation of endothelial polarization by Apelin receptor signalling Regulation of vascular tone by adipocytes.Apelin increases cardiac contractility via protein kinase Cε- and extracellular signal-regulated kinase-dependent mechanisms Differential Contribution of Transmembrane Domains IV, V, VI, and VII to Human Angiotensin II Type 1 Receptor Homomer Formation.Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation.In silico Therapeutics for Neurogenic Hypertension and Vasovagal Syncope.Emerging Metabolic Therapies in Pulmonary Arterial Hypertension.MiR-125b Is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis.Role of the Vasopressin/Apelin Balance and Potential Use of Metabolically Stable Apelin Analogs in Water Metabolism Disorders.Upregulation of the apelin-APJ pathway promotes neointima formation in the carotid ligation model in mouse Angiotensin II type 2 receptor ligand PD123319 attenuates hyperoxia-induced lung and heart injury at a low dose in newborn rats.Oxidative stress and metabolic pathologies: from an adipocentric point of view.Modulation of the apelin/APJ system in heart failure and atherosclerosis in man ERG-APLNR axis controls pulmonary venule endothelial proliferation in pulmonary veno-occlusive disease.An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension Angiopoietins, abdominal aortic aneurysm and atherosclerosis.Identification of serine 348 on the apelin receptor as a novel regulatory phosphorylation site in apelin-13-induced G protein-independent biased signaling.Apelin decreases lipolysis via G(q), G(i), and AMPK-Dependent Mechanisms.Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK(1/2) and cell proliferation via Gαq-mediated mechanism Functional enhancement of AT1R potency in the presence of the TPαR is revealed by a comprehensive 7TM receptor co-expression screen.Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension AT1R-CB₁R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II.APpEaLINg therapeutic target for obesity cardiomyopathy?Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1.Apelin and insulin resistance: another arrow for the quiver?Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension Apelin and pulmonary hypertension.Association of SNP Rs9943582 in APLNR with Left Ventricle Systolic Dysfunction in Patients with Coronary Artery Disease in a Chinese Han GeneID Population Mechanisms of thrombosis in obesity.Biological Significance of GPCR Heteromerization in the Neuro-Endocrine System Serum apelin is associated with left ventricular hypertrophy in untreated hypertension patients.APJ acts as a dual receptor in cardiac hypertrophy.Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report.Apelin and vascular endothelial growth factor are associated with mobilization of endothelial progenitor cells after acute myocardial infarction.

P2860

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P2860

Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

http://www.wikidata.org/entity/Q24657323

description

2008 nî lūn-bûn

@nan

2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

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2008年論文

@zh-tw

2008年论文

@wuu

name

Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

@ast

Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

@en

Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

@nl

type

label

Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

@ast

Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

@en

Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

@nl

prefLabel

Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

@ast

Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

@en

Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

@nl

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P1433

Journal of Clinical Investigation

P1476

Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

@en

P2093

Ahmad Y Sheikh

http://www.w3.org/2001/XMLSchema#string

Andrew J Patterson

http://www.w3.org/2001/XMLSchema#string

Euan A Ashley

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Hyung J Chun

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Joshua P Anderson

http://www.w3.org/2001/XMLSchema#string

Lixin Zheng

http://www.w3.org/2001/XMLSchema#string

Michael J Lenardo

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Nathan E Pearl

http://www.w3.org/2001/XMLSchema#string

Nicholas J Leeper

http://www.w3.org/2001/XMLSchema#string

Philip S Tsao

http://www.w3.org/2001/XMLSchema#string

P2860

Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor

AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration

A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11

The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo

Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression

Characterization of apelin, the ligand for the APJ receptor

APJ receptor mRNA expression in the rat hypothalamic paraventricular nucleus: regulation by stress and glucocorticoids

The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism

Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility

Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo

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3343-54

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scholarly article

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4232754

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10.1172/JCI34871

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P433

10

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118

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Thomas Quertermous

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2008-10-01T00:00:00Z

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23236092

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18769630

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P921

atherosclerosis

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2525695

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