about
The discovery of a novel antibiotic for the treatment of Clostridium difficile infections: a story of an effective academic–industrial partnershipNovel amidines and analogues as promising agents against intracellular parasites: a systematic reviewSmall-molecule Binding to the DNA Minor Groove Is Mediated by a Conserved Water ClusterSequence-dependent effects in drug-DNA interaction: the crystal structure of Hoechst 33258 bound to the d(CGCAAATTTGCG)2 duplexStructure of a bis-amidinium derivative of hoechst 33258 complexed to dodecanucleotide d(CGCGAATTCGCG)2: the role of hydrogen bonding in minor groove drug-DNA recognitionFTIR study of specific binding interactions between DNA minor groove binding ligands and polynucleotides.Design, synthesis and biological evaluation of a novel class of anticancer agents: anthracenylisoxazole lexitropsin conjugatesSynthetic metallomolecules as agents for the control of DNA structure.Origins of netropsin binding affinity and specificity: correlations of thermodynamic and structural dataTheoretical study on binding of Hoechst 33258 with oligonucleotides.Interaction of Hoechst 33258 with repeating synthetic DNA polymers and natural DNA.DNA-sequence specific recognition by a thiazole analogue of netropsin: a comparative footprinting study.Molecular recognition analyzed by docking simulations: the aspartate receptor and isocitrate dehydrogenase from Escherichia coliIdentification of DNA-binding proteins using multi-features fusion and binary firefly optimization algorithm.Estimation of the DNA sequence discriminatory ability of hairpin-linked lexitropsins.The theoretical limits of DNA sequence discrimination by linked polyamidesTheoretical studies employing an ab initio and molecular modeling combination method on the DNA binding of bis-benzimidazoles designed for bioreductive activation.A role for water molecules in DNA-ligand minor groove recognitionDesign of DNA minor groove binding diamidines that recognize GC base pair sequences: a dimeric-hinge interaction motif.Binding to the DNA minor groove by heterocyclic dications: from AT-specific monomers to GC recognition with dimers.Structural basis of DNA recognition by anticancer antibiotics, chromomycin A(3), and mithramycin: roles of minor groove width and ligand flexibility.Minor-groove width and accessibility in B-DNA drug and protein complexes.The binding of prototype lexitropsins to the minor groove of DNA: quantum chemical studies.Drug recognition of DNA. Proposal for GC minor groove specific ligands: vinylexins.Theoretical study of the sequence selectivity of isolexins, isohelical DNA groove binding ligands. Proposal for the GC minor groove specific compounds.Progress in the design of DNA sequence-specific lexitropsins.Anti-Pneumocystis carinii pneumonia activity of dicationic 2,4-diarylpyrimidines.Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues.DNA structure and perturbation by drug bindingInteraction of berenil with the tyrT DNA sequence studied by footprinting and molecular modelling. Implications for the design of sequence-specific DNA recognition agents.The crystal structure of the DNA-binding drug berenil: molecular modelling studies of berenil-DNA complexes.Molecular dynamics of water-mediated interactions of a linear benzimidazole-biphenyl diamidine with the DNA minor groove.Double helix conformation, groove dimensions and ligand binding potential of a G/C stretch in B-DNA.Synthesis of dicationic diaryltriazines nucleic acid binding agents.Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum.Theoretical modeling of DNA-monocationic lexitropsin complexation: influence of ligand binding on DNA curvature.Novel class of DNA binding motifs based on bistetrahydrofuran and bisfuran skeleton with long alkyl chains.Geometrical correlations useful for design of sequence-specific DNA narrow groove binding ligands.Molecular recognition and binding of a GC site-avoiding thiazole-lexitropsin to the decadeoxyribonucleotide d-[CGCAATTGCG]2: 1H-NMR evidence for thiazole intercalation.Modulation of DNA supercoiling by interaction with netropsin and other minor groove binders.
P2860
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P2860
description
1986 nî lūn-bûn
@nan
1986 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1986 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
name
Isohelical analysis of DNA groove-binding drugs.
@ast
Isohelical analysis of DNA groove-binding drugs.
@en
type
label
Isohelical analysis of DNA groove-binding drugs.
@ast
Isohelical analysis of DNA groove-binding drugs.
@en
prefLabel
Isohelical analysis of DNA groove-binding drugs.
@ast
Isohelical analysis of DNA groove-binding drugs.
@en
P356
P1476
Isohelical analysis of DNA groove-binding drugs.
@en
P2093
Dickerson RE
Goodsell D
P304
P356
10.1021/JM00155A023
P407
P577
1986-05-01T00:00:00Z