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Pharmacological characterization of antagonists of the C5a receptor

Pharmacological characterization of antagonists of the C5a receptor

http://www.wikidata.org/entity/Q35041753

about

C5L2 is a functional receptor for acylation-stimulating protein The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist Identification of a potent and orally active non-peptide C5a receptor antagonist.Complement and its implications in cardiac ischemia/reperfusion: strategies to inhibit complement.Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury The proinflammatory mediators C3a and C5a are essential for liver regeneration C5a receptor-dependent cell activation by physiological concentrations of desarginated C5a: insights from a novel label-free cellular assay.C5a Regulates IL-1β Production and Leukocyte Recruitment in a Murine Model of Monosodium Urate Crystal-Induced Peritonitis.The human complement fragment receptor, C5L2, is a recycling decoy receptor.Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site.Local endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy.High-Fat Diet-Induced Complement Activation Mediates Intestinal Inflammation and Neoplasia, Independent of Obesity.Characterisation of receptor binding by the chemotaxis inhibitory protein of Staphylococcus aureus and the effects of the host immune response Molecular characterization of the gerbil C5a receptor and identification of a transmembrane domain V amino acid that is crucial for small molecule antagonist interaction.Pivotal Advance: Interconversion between pure chemotactic ligands and chemoattractant/secretagogue ligands of neutrophil C5a receptor by a single amino acid substitution.Thrombin-activatable fibrinolysis inhibitor protects against acute lung injury by inhibiting the complement system.Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis.Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors.Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice.

P2860

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P2860

Pharmacological characterization of antagonists of the C5a receptor

http://www.wikidata.org/entity/Q35041753

description

1999 nî lūn-bûn

@nan

1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

1999年の論文

@ja

1999年論文

@yue

1999年論文

@zh-hant

1999年論文

@zh-hk

1999年論文

@zh-mo

1999年論文

@zh-tw

1999年论文

@wuu

name

Pharmacological characterization of antagonists of the C5a receptor

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type

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Pharmacological characterization of antagonists of the C5a receptor

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Pharmacological characterization of antagonists of the C5a receptor

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P1433

British Journal of Pharmacology

P1476

Pharmacological characterization of antagonists of the C5a receptor

@en

P2093

A J Short

http://www.w3.org/2001/XMLSchema#string

A K Wong

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D P Fairlie

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J B Whitmore

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N J Paczkowski

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P N Monk

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S A Cain

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S M Taylor

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P2860

Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells

Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke

C5A anaphylatoxin and its seven transmembrane-segment receptor

Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene

The chemotactic receptor for human C5a anaphylatoxin

CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin

Identification of receptor-binding residues in the inflammatory complement protein C5a by site-directed mutagenesis

Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat.

Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors.

Site-specific mutagenesis of residues in the human C5a anaphylatoxin which are involved in possible interaction with the C5a receptor.

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1461-1466

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10.1038/SJ.BJP.0702938

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7

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128

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1999-12-01T00:00:00Z

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12699744

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10602324

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1571783

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