Pharmacological characterization of antagonists of the C5a receptor
about
C5L2 is a functional receptor for acylation-stimulating proteinThe role of the N-terminal domain of the complement fragment receptor C5L2 in ligand bindingC5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonismInhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonistIdentification of a potent and orally active non-peptide C5a receptor antagonist.Complement and its implications in cardiac ischemia/reperfusion: strategies to inhibit complement.Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injuryThe proinflammatory mediators C3a and C5a are essential for liver regenerationC5a receptor-dependent cell activation by physiological concentrations of desarginated C5a: insights from a novel label-free cellular assay.C5a Regulates IL-1β Production and Leukocyte Recruitment in a Murine Model of Monosodium Urate Crystal-Induced Peritonitis.The human complement fragment receptor, C5L2, is a recycling decoy receptor.Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site.Local endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy.High-Fat Diet-Induced Complement Activation Mediates Intestinal Inflammation and Neoplasia, Independent of Obesity.Characterisation of receptor binding by the chemotaxis inhibitory protein of Staphylococcus aureus and the effects of the host immune responseMolecular characterization of the gerbil C5a receptor and identification of a transmembrane domain V amino acid that is crucial for small molecule antagonist interaction.Pivotal Advance: Interconversion between pure chemotactic ligands and chemoattractant/secretagogue ligands of neutrophil C5a receptor by a single amino acid substitution.Thrombin-activatable fibrinolysis inhibitor protects against acute lung injury by inhibiting the complement system.Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis.Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors.Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice.
P2860
Q24300165-4CB2710A-82FC-42F0-BCC1-975A5E63D9F8Q24610523-A5144BAE-51B0-4C8A-8DBB-6CDA33D6B790Q28211612-63E8D798-571C-4ABE-A4F7-9B401BE6DC02Q28366075-10958542-2787-43D7-9A83-088D39676B00Q34154819-6085F492-43C5-4A32-A290-89CBC2890608Q34570640-2D39EE9B-4B99-4E5E-B272-DA2F112B48CFQ35047279-BDEAD074-CF04-4C64-A0F2-2CBE8B5305F0Q36371713-FB092047-899A-44B3-BFE1-287BDF6A7687Q36463676-13F3E80D-55FA-485D-9992-0F08098278B7Q37597916-9A40EC47-9243-428B-AE9B-A29424935081Q39902889-3D313D4D-5B04-41A0-AFE7-EF4C6C4FE0E3Q40468378-DD56E64A-3344-4ECB-9F0D-AC54B6BD2A6BQ41068034-224A2891-A4FC-4E37-9EC0-03607621AD37Q41653522-C62B42D8-5579-477D-AE10-BFA5B45D641BQ41773639-CB783083-05FA-449F-A38A-C5FEEB159300Q42670931-DC7D0173-CC7F-4BA3-B76C-21C895EA26E3Q43188289-C41504A8-AD7E-445B-8B0E-B4D159AE4D75Q44995190-FB3F8F5D-F226-40B9-82E7-CA4F9FE5AF8DQ48304802-B9FF87E7-7F50-4430-9B00-7F1E9949289DQ50277552-66BC8B03-F452-48FF-9719-8A8D95F3503FQ55311354-47B5989C-CAE1-4A68-84F0-D355503106C3
P2860
Pharmacological characterization of antagonists of the C5a receptor
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Pharmacological characterization of antagonists of the C5a receptor
@en
type
label
Pharmacological characterization of antagonists of the C5a receptor
@en
prefLabel
Pharmacological characterization of antagonists of the C5a receptor
@en
P2093
P2860
P356
P1476
Pharmacological characterization of antagonists of the C5a receptor
@en
P2093
D P Fairlie
J B Whitmore
N J Paczkowski
S M Taylor
P2860
P304
P356
10.1038/SJ.BJP.0702938
P407
P577
1999-12-01T00:00:00Z