Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates.
about
Controlling the subcellular localization of DNA polymerases iota and eta via interactions with ubiquitinExpression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genesMSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sitesStructural basis for recruitment of translesion DNA polymerase Pol IV/DinB to the -clampStructural basis of error-prone replication and stalling at a thymine base by human DNA polymerase ιIncreased mutagenesis and unique mutation signature associated with mitotic gene conversion129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutationTranslesion synthesis past equine estrogen-derived 2'-deoxyadenosine DNA adducts by human DNA polymerases eta and kappa.PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance.Genesis of the strand-biased signature in somatic hypermutation of rearranged immunoglobulin variable genes.Human DNA polymerase-eta, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase.Chromosome organization and chromatin modification: influence on genome function and evolution.The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated.The critical mutagenic translesion DNA polymerase Rev1 is highly expressed during G(2)/M phase rather than S phaseA novel function of DNA polymerase zeta regulated by PCNA.What role for AID: mutator, or assembler of the immunoglobulin mutasome?Pre-steady state kinetic studies show that an abasic site is a cognate lesion for the yeast Rev1 protein.DNA replication fidelity.The boundaries of the distribution of somatic hypermutation of rearranged immunoglobulin variable genes.On the molecular mechanism of somatic hypermutation of rearranged immunoglobulin genes.Expression and possible functions of DNA lesion bypass proteins in spermatogenesis.The L561A substitution in the nascent base-pair binding pocket of RB69 DNA polymerase reduces base discrimination.Mechanism of translesion synthesis past an equine estrogen-DNA adduct by Y-family DNA polymerases.Translesion DNA polymerases and cancerSuffering in silence: the tolerance of DNA damage.Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombinationDNA damage responses and their many interactions with the replication fork.The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regionsContribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouseIntricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation.Chemical synthesis of oligonucleotides containing damaged bases for biological studies.Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis.Evolving views of DNA replication (in)fidelity.Translesion synthesis past tamoxifen-derived DNA adducts by human DNA polymerases eta and kappaIdentification of murine B cell lines that undergo somatic hypermutation focused to A:T and G:C residues.DNA damage tolerance: a double-edged sword guarding the genomeDNA polymerase eta and chemotherapeutic agents.Mouse models of DNA polymerases.ASFV DNA polymerse X is extremely error-prone under diverse assay conditions and within multiple DNA sequence contextsRoles of the Y-family DNA polymerase Dbh in accurate replication of the Sulfolobus genome at high temperature.
P2860
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P2860
Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates.
description
2003 nî lūn-bûn
@nan
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Functions of human DNA polymer ...... with undamaged DNA templates.
@en
type
label
Functions of human DNA polymer ...... with undamaged DNA templates.
@en
prefLabel
Functions of human DNA polymer ...... with undamaged DNA templates.
@en
P1433
P1476
Functions of human DNA polymer ...... y with undamaged DNA templates
@en
P2093
Katarzyna Bebenek
Youri I Pavlov
P304
P356
10.1016/S1568-7864(02)00224-0
P577
2003-02-01T00:00:00Z