Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse
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The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutationRegulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombinationTranscriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrityMechanism of somatic hypermutation at the WA motif by human DNA polymerase η.Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activitiesDNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.Participation of mouse DNA polymerase iota in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancerATAD5 deficiency decreases B cell division and Igh recombinationTemporal regulation of Ig gene diversification revealed by single-cell imaging.Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter.The Fanconi anemia core complex is dispensable during somatic hypermutation and class switch recombination.A role for PCNA ubiquitination in immunoglobulin hypermutation.DNA-dependent protein kinase inhibits AID-induced antibody gene conversion.Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells.Somatic hypermutation at A/T-rich oligonucleotide substrates shows different strand polarities in Ung-deficient or -proficient backgrounds.Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA.Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversificationRefining the Neuberger model: Uracil processing by activated B cells.Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.AID and somatic hypermutation.Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutationControlling somatic hypermutation in immunoglobulin variable and switch regions.Redundancy of mammalian Y family DNA polymerases in cellular responses to genomic DNA lesions induced by ultraviolet lightDNA polymerases and somatic hypermutation of immunoglobulin genesThe pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated.DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse.p21 is dispensable for AID-mediated class switch recombination and mutagenesis of immunoglobulin genes during somatic hypermutation.Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iotaMismatch-mediated error prone repair at the immunoglobulin genes.Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase η in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias129-Derived Mouse Strains Express an Unstable but Catalytically Active DNA Polymerase Iota VariantWhat a difference a decade makes: insights into translesion DNA synthesis.HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligaseDoes DNA repair occur during somatic hypermutation?A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation.DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination.A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification
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P2860
Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse
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2005 nî lūn-bûn
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2005年の論文
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年學術文章
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2005年學術文章
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2005年學術文章
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name
Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse
@ast
Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse
@en
type
label
Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse
@ast
Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse
@en
prefLabel
Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse
@ast
Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse
@en
P2093
P2860
P356
P1476
Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse
@en
P2093
Ahmad Faili
Annie De Smet
Claude-Agnès Reynaud
Frédéric Delbos
Jean-Claude Weill
Said Aoufouchi
P2860
P304
P356
10.1084/JEM.20050292
P407
P577
2005-04-11T00:00:00Z