Inhibition of the PI3K/Akt/GSK3 pathway downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD downregulates DNA damage-induced Chk1 activation as well as G2/M arrest and prominently enhances induction of apoptosis.
about
Proteasome inhibitor MG132 inhibits the proliferation and promotes the cisplatin-induced apoptosis of human esophageal squamous cell carcinoma cells.Activation of CHK1 in Supporting Cells Indirectly Promotes Hair Cell SurvivalInvestigational FMS-like tyrosine kinase 3 inhibitors in treatment of acute myeloid leukemiaRevealing very small FLT3 ITD mutated clones by ultra-deep sequencing analysis has important clinical implications in AML patients.Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells.Down regulation of Chk1 by p53 plays a role in synergistic induction of apoptosis by chemotherapeutics and inhibitors for Jak2 or BCR/ABL in hematopoietic cells.A novel function of hepatocyte growth factor in the activation of checkpoint kinase 1 phosphorylation in colon cancer cells.Genomic instability is a principle pathologic feature of FLT3 ITD kinase activity in acute myeloid leukemia leading to clonal evolution and disease progression.EMAP-II sensitize U87MG and glioma stem-like cells to temozolomide via induction of autophagy-mediated cell death and G2/M arrest.Gelidiella acerosa inhibits lung cancer proliferation.
P2860
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P2860
Inhibition of the PI3K/Akt/GSK3 pathway downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD downregulates DNA damage-induced Chk1 activation as well as G2/M arrest and prominently enhances induction of apoptosis.
description
2013 nî lūn-bûn
@nan
2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Inhibition of the PI3K/Akt/GSK ...... hances induction of apoptosis.
@en
type
label
Inhibition of the PI3K/Akt/GSK ...... hances induction of apoptosis.
@en
prefLabel
Inhibition of the PI3K/Akt/GSK ...... hances induction of apoptosis.
@en
P2093
P2860
P1433
P1476
Inhibition of the PI3K/Akt/GSK ...... nhances induction of apoptosis
@en
P2093
Gaku Oshikawa
Tetsuya Kurosu
Toshikage Nagao
P2860
P304
P356
10.1371/JOURNAL.PONE.0079478
P407
P50
P577
2013-11-18T00:00:00Z