High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/β-catenin target gene, CDC25A. - Wikidata - awgldk - TriplyDB

High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/β-catenin target gene, CDC25A.

High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/β-catenin target gene, CDC25A.

http://www.wikidata.org/entity/Q35049311

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Human Sarcoma growth is sensitive to small-molecule mediated AXIN stabilization.β-Catenin transcriptional activity is minimal in canine osteosarcoma and its targeted inhibition results in minimal changes to cell line behaviour.Oncopig Soft-Tissue Sarcomas Recapitulate Key Transcriptional Features of Human Sarcomas A systems biology approach reveals common metastatic pathways in osteosarcoma.The Wnt/β-catenin pathway in human fibrotic-like diseases and its eligibility as a therapeutic target.Gene expression patterns of hemizygous and heterozygous KIT mutations suggest distinct oncogenic pathways: a study in NIH3T3 cell lines and GIST samples.β-Catenin-independent activation of TCF1/LEF1 in human hematopoietic tumor cells through interaction with ATF2 transcription factors.Autocrine Activation of the Wnt/β-Catenin Pathway by CUX1 and GLIS1 in Breast Cancers.3D tissue-engineered model of Ewing's sarcoma Cancer biology: a new RING to Wnt signaling.Deregulation of the Hippo pathway in soft-tissue sarcoma promotes FOXM1 expression and tumorigenesis A transgenic, mesodermal specific, Dkk1 mouse model recapitulates a spectrum of human congenital limb reduction defects.Update on Wnt signaling in bone cell biology and bone disease.Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver.Oxidized ATM promotes abnormal proliferation of breast CAFs through maintaining intracellular redox homeostasis and activating the PI3K-AKT, MEK-ERK, and Wnt-β-catenin signaling pathways.Aberrant activation of Wnt/β-catenin signaling drives proliferation of bone sarcoma cells.Precise regulation of porcupine activity is required for physiological Wnt signaling.FOXO1 inhibits osteosarcoma oncogenesis via Wnt/β-catenin pathway suppression.The molecular landscape of extraskeletal osteosarcoma: A clinicopathological and molecular biomarker study.Clinical Observations and Molecular Variables of Primary Vascular Leiomyosarcoma Deciphering signaling networks in osteosarcoma pathobiology.Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling Epigenetic and epigenomic mechanisms shape sarcoma and other mesenchymal tumor pathogenesis.Perspectives on cancer stem cells in osteosarcoma Genome-wide analyses on high-grade osteosarcoma: making sense of a genomically most unstable tumor.Senescence bypass in mesenchymal stem cells: a potential pathogenesis and implications of pro-senescence therapy in sarcomas.Cell cycle and cell fate in the developing nervous system: the role of CDC25B phosphatase.Targeting the WNT Signaling Pathway in Cancer Therapeutics.The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma.Activation of Wnt/β-Catenin in Ewing Sarcoma Cells Antagonizes EWS/ETS Function and Promotes Phenotypic Transition to More Metastatic Cell States.Nuclear phosphorylated Y142 β-catenin accumulates in astrocytomas and glioblastomas and regulates cell invasion.SS18-SSX fusion protein-induced Wnt/β-catenin signaling is a therapeutic target in synovial sarcoma.Targeting the Wnt pathway in synovial sarcoma models.Canonical Wnt signaling induces a primitive endoderm metastable state in mouse embryonic stem cells.MiR-155 is a liposarcoma oncogene that targets casein kinase-1α and enhances β-catenin signaling.Wnt Signaling in Ewing Sarcoma, Osteosarcoma, and Malignant Peripheral Nerve Sheath Tumors.LGR5 is Expressed by Ewing Sarcoma and Potentiates Wnt/β-Catenin Signaling.Extracellular LDLR repeats modulate Wnt signaling activity by promoting LRP6 receptor endocytosis mediated by the Itch E3 ubiquitin ligase.Integrated analysis of the Wnt responsive proteome in human cells reveals diverse and cell-type specific networks.Comparison of gene expression profiling in sarcomas and mesenchymal stem cells identifies tumorigenic pathways in chemically induced rat sarcoma model.

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P2860

High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/β-catenin target gene, CDC25A.

http://www.wikidata.org/entity/Q35049311

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2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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High-frequency canonical Wnt a ...... β-catenin target gene, CDC25A.

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High-frequency canonical Wnt a ...... β-catenin target gene, CDC25A.

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High-frequency canonical Wnt a ...... β-catenin target gene, CDC25A.

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High-frequency canonical Wnt a ...... β-catenin target gene, CDC25A.

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J.CCR.2011.03.010

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High-frequency canonical Wnt a ...... β-catenin target gene, CDC25A.

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Gal Akiri

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Guizhong Liu

http://www.w3.org/2001/XMLSchema#string

Ioana A Rus

http://www.w3.org/2001/XMLSchema#string

Sapna Vijayakumar

http://www.w3.org/2001/XMLSchema#string

Shen Yao

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Stuart A Aaronson

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Yan Chen

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P2860

Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling

The Hallmarks of Cancer

Inhibition of adipogenesis by Wnt signaling

LDL-receptor-related proteins in Wnt signal transduction

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling

Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway

Identification of c-MYC as a target of the APC pathway

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

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5

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21575861

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3116447

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