Advent of Imidazo[1,2-a]pyridine-3-carboxamides with Potent Multi- and Extended Drug Resistant Antituberculosis Activity - Wikidata - awgldk - TriplyDB

Advent of Imidazo[1,2-a]pyridine-3-carboxamides with Potent Multi- and Extended Drug Resistant Antituberculosis Activity

Advent of Imidazo[1,2-a]pyridine-3-carboxamides with Potent Multi- and Extended Drug Resistant Antituberculosis Activity

http://www.wikidata.org/entity/Q35052626

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Next-generation antimicrobials: from chemical biology to first-in-class drugs Identification of novel imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB A dual read-out assay to evaluate the potency of compounds active against Mycobacterium tuberculosis Bactericidal activity of an imidazo[1, 2-a]pyridine using a mouse M. tuberculosis infection model Endless Resistance. Endless Antibiotics?Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis.Scaffold-switching: an exploration of 5,6-fused bicyclic heteroaromatics systems to afford antituberculosis activity akin to the imidazo[1,2-a]pyridine-3-carboxylates.Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection.Isolation and Characterization of a Hybrid Respiratory Supercomplex Consisting of Mycobacterium tuberculosis Cytochrome bcc and Mycobacterium smegmatis Cytochrome aa3.Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis.Respiratory flexibility in response to inhibition of cytochrome C oxidase in Mycobacterium tuberculosis.Putting Tuberculosis (TB) To Rest: Transformation of the Sleep Aid, Ambien, and "Anagrams" Generated Potent Antituberculosis Agents.4'-(4-Bromo-phen-yl)-1'-methyl-dispiro-[indan-2,2'-pyrrolidine-3',2''-indan]-1,3,1''-trione.The tuberculosis drug discovery and development pipeline and emerging drug targets.Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds.Design, Synthesis, and Biological Evaluation of Pyrazolo[1,5-a]pyridine-3-carboxamides as Novel Antitubercular Agents.A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis Bicyclic Cyclohexenones as Inhibitors of NF-κB Signaling.SAR and identification of 2-(quinolin-4-yloxy)acetamides as Mycobacterium tuberculosis cytochrome bc1 inhibitors Advancement of Imidazo[1,2-a]pyridines with Improved Pharmacokinetics and Nanomolar Activity Against Mycobacterium tuberculosis.Imidazo[1,2-a]Pyridine-3-Carboxamides Are Active Antimicrobial Agents against Mycobacterium avium Infection In Vivo Liposomes as drug delivery systems for the treatment of TB.Tuberculosis drug discovery and emerging targets.New structural classes of antituberculosis agents.Design, syntheses, and anti-tuberculosis activities of conjugates of piperazino-1,3-benzothiazin-4-ones (pBTZs) with 2,7-dimethylimidazo [1,2-a]pyridine-3-carboxylic acids and 7-phenylacetyl cephalosporins.Preparation and Evaluation of Potent Pentafluorosulfanyl-Substituted Anti-Tuberculosis Compounds.The synthesis and evaluation of triazolopyrimidines as anti-tubercular agents.Evaluation of structurally diverse benzoazepines clubbed with coumarins as Mycobacterium tuberculosis agents.Preparation of imidazo[1,2-a]-N-heterocyclic derivatives with gem-difluorinated side chains.Identification of N-(2-Phenoxyethyl)imidazo[1,2-a]pyridine-3-carboxamides as New Antituberculosis Agents.Mycobacterial Membrane Proteins QcrB and AtpE: Roles in Energetics, Antibiotic Targets, and Associated Mechanisms of Resistance.The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd.A Cu(ii)-promoted tandem decarboxylative halogenation and oxidative diamination reaction of 2-aminopyridines with alkynoic acids for the synthesis of 2-haloimidazo[1,2-a]pyridines.Indium triflate promoted one-pot multicomponent synthesis of structurally diverse 3-amino-imidazo[1,2-a]pyridines.An unprecedented Pd-catalyzed decarboxylative coupling reaction of aromatic carboxylic acids in aqueous medium under air: synthesis of 3-aryl-imidazo[1,2-a]pyridines from aryl chlorides.Imidazopyridine compounds inhibit mycobacterial growth by depleting ATP levels.Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targets.Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions Superparamagnetic CuFeO2Nanoparticles in Deep Eutectic Solvent: an Efficient and Recyclable Catalytic System for the Synthesis of Imidazo[1,2-a]pyridines

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Advent of Imidazo[1,2-a]pyridine-3-carboxamides with Potent Multi- and Extended Drug Resistant Antituberculosis Activity

http://www.wikidata.org/entity/Q35052626

description

2011 nî lūn-bûn

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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2011 թվականի հունիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Advent of Imidazo[1,2-a]pyridi ...... tant Antituberculosis Activity

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ACS Medicinal Chemistry Letters

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Advent of Imidazo[1,2-a]pyridi ...... tant Antituberculosis Activity

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P2093

Helena Boshoff

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Lowell D Markley

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Marvin J Miller

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Philip A Hipskind

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Sanghyun Cho

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P2860

A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis

The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages

Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium

Characterization of the cydAB-encoded cytochrome bd oxidase from Mycobacterium smegmatis.

In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.

Structure-activity relationship of new anti-tuberculosis agents derived from oxazoline and oxazole benzyl esters.

Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection

First tuberculosis cases in Italy resistant to all tested drugs.

UTILIZTION OF THE SUZUKI COUPLING TO ENHANCE THE ANTITUBERCULOSIS ACTIVITY OF ARYL OXAZOLES.

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy.

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466-470

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scholarly article

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10.1021/ML200036R

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6

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2

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Scott G. Franzblau

Garrett C Moraski

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2011-06-01T00:00:00Z

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51236730

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21691438

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3117668

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