Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s).
about
Cloning and expression of human deoxycytidine kinase cDNAGenomic structure and chromosomal localization of the human deoxycytidine kinase genePoint mutations at the purine nucleoside phosphorylase locus impair thymocyte differentiation in the mouseCloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinasesIdentification of targets and new developments in the treatment of multiple sclerosis--focus on cladribineIntron requirement for expression of the human purine nucleoside phosphorylase geneSequence and functional characterization of the human purine nucleoside phosphorylase promoterHuman purine nucleoside phosphorylase cDNA sequence and genomic clone characterizationMolecular analysis of mutations in a patient with purine nucleoside phosphorylase deficiencyCladribine tablets for the treatment of relapsing-remitting multiple sclerosisDeoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivoThe metabolism of deoxyguanosine and guanosine in human B and T lymphoblasts. A role for deoxyguanosine kinase activity in the selective T-cell defect associated with purine nucleoside phosphorylase deficiencyB cells as well as T cells form deoxynucleotides from either deoxyadenosine or deoxyguanosineResistance of pokeweed mitogen-stimulated B cells to inhibition by deoxyadenosineDevelopment of oral immunomodulatory agents in the management of multiple sclerosisTissue-specific rescue suggests that placental adenosine deaminase is important for fetal development in miceDeficiency of purine nucleoside phosphorylase activity in thymocytes from the immunodeficient diabetic BB ratMitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient miceFurther differentiation of murine double-positive thymocytes is inhibited in adenosine deaminase-deficient murine fetal thymic organ cultureCladribine in the treatment of chronic lymphocytic leukemia.Heberden oration 1979: human aberrations of purine metabolism and their significance for rheumatology.Forodesine: review of preclinical and clinical data.Requirement for deoxycytidine kinase in T and B lymphocyte development.Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiencyp53 expression is required for thymocyte apoptosis induced by adenosine deaminase deficiency.Influence of bone marrow stromal microenvironment on forodesine-induced responses in CLL primary cells.Characterization of the deoxycytidine kinase promoter in human lymphoblast cell linesChronic cladribine administration increases amyloid beta peptide generation and plaque burden in mice.Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytesSpecific cytotoxicity of arabinosylguanine toward cultured T lymphoblastsCombined immunodeficiency and thymic abnormalities.Ecto-5'-nucleotidase activity in human T cell subsets. Decreased numbers of ecto-5'-nucleotidase positive cells from both OKT4+ and OKT8+ cells in patients with hypogammaglobulinemia.Purine metabolism in myeloid precursor cells during maturation. Studies with the HL-60 cell lineNucleoside kinases in T and B lymphoblasts distinguished by autoradiography.A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine)Adenosine deaminase deficiency: unanticipated benefits from the study of a rare immunodeficiencyPurinogenic immunodeficiency diseases: selective toxicity of deoxyribonucleosides for T cells.Restoring balance to B cells in ADA deficiencyAntileukemic and immunosuppressive activity of 2-chloro-2'-deoxyadenosine.Possible metabolic basis for the different immunodeficient states associated with genetic deficiencies of adenosine deaminase and purine nucleoside phosphorylase
P2860
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P2860
Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s).
description
1977 nî lūn-bûn
@nan
1977 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1977 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1977年の論文
@ja
1977年論文
@yue
1977年論文
@zh-hant
1977年論文
@zh-hk
1977年論文
@zh-mo
1977年論文
@zh-tw
1977年论文
@wuu
name
Lymphospecific toxicity in ade ...... role of nucleoside kinase(s).
@ast
Lymphospecific toxicity in ade ...... role of nucleoside kinase(s).
@en
type
label
Lymphospecific toxicity in ade ...... role of nucleoside kinase(s).
@ast
Lymphospecific toxicity in ade ...... role of nucleoside kinase(s).
@en
prefLabel
Lymphospecific toxicity in ade ...... role of nucleoside kinase(s).
@ast
Lymphospecific toxicity in ade ...... role of nucleoside kinase(s).
@en
P2093
P2860
P356
P1476
Lymphospecific toxicity in ade ...... role of nucleoside kinase(s).
@en
P2093
P2860
P304
P356
10.1073/PNAS.74.12.5677
P407
P577
1977-12-01T00:00:00Z