Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration. - Wikidata - awgldk - TriplyDB

Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.

Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.

http://www.wikidata.org/entity/Q35054916

about

Kynurenines in CNS disease: regulation by inflammatory cytokines Chronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence?Targeting New Candidate Genes by Small Molecules Approaching Neurodegenerative Diseases Indoleamine 2,3 Dioxygenase as a Potential Therapeutic Target in Huntington's Disease Kynurenine 3-Monooxygenase: An Influential Mediator of Neuropathology Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes Mitochondrial targets for pharmacological intervention in human disease Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?Kynurenines in the mammalian brain: when physiology meets pathology Mouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Huntington's disease: underlying molecular mechanisms and emerging concepts Chemical dampening of Ly6C(hi) monocytes in the periphery produces anti-depressant effects in mice.Structural basis of kynurenine 3-monooxygenase inhibition Changing the face of kynurenines and neurotoxicity: therapeutic considerations The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease A system-level investigation into the mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for cardiovascular disease treatment GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites Targeted Deletion of Kynurenine 3-Monooxygenase in Mice: A NEW TOOL FOR STUDYING KYNURENINE PATHWAY METABOLISM IN PERIPHERY AND BRAIN Siderophores; iron scavengers: the novel & promising targets for pathogen specific antifungal therapy.Serine 421 regulates mutant huntingtin toxicity and clearance in mice.Mutant huntingtin impairs immune cell migration in Huntington disease.Model of tryptophan metabolism, readily scalable using tissue-specific gene expression data.Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington's disease.Leveraging existing data sets to generate new insights into Alzheimer's disease biology in specific patient subsets.Recent Progress in Alzheimer's Disease Research, Part 3: Diagnosis and Treatment.Modeling Huntington disease in yeast: perspectives and future directions.Microglial Activation in the Pathogenesis of Huntington's Disease.High-Fat Diet and Voluntary Chronic Aerobic Exercise Recover Altered Levels of Aging-Related Tryptophan Metabolites along the Kynurenine Pathway.A small-molecule screen identifies L-kynurenine as a competitive inhibitor of TAA1/TAR activity in ethylene-directed auxin biosynthesis and root growth in Arabidopsis.Effects of antidepressants and cyclooxygenase-2 inhibitor on cytokines and kynurenines in stimulated in vitro blood culture from depressed patients.Identification of common genetic modifiers of neurodegenerative diseases from an integrative analysis of diverse genetic screens in model organisms Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons.Evidence for cognitive impairment in mastocytosis: prevalence, features and correlations to depression.Excitotoxic brain injury in adult zebrafish stimulates neurogenesis and long-distance neuronal integration.Targets for future clinical trials in Huntington's disease: what's in the pipeline?Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.Expression of tryptophan 2,3-dioxygenase and production of kynurenine pathway metabolites in triple transgenic mice and human Alzheimer's disease brain Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder.Transcriptomic responses to emamectin benzoate in Pacific and Atlantic Canada salmon lice Lepeophtheirus salmonis with differing levels of drug resistance.

P2860

Q21129356-7787DF19-DD1A-4B68-B56A-58EBEA640829 Q26770781-D37E61EE-9930-4C45-88BF-E344EB0203B9 Q26771812-6459C430-F62F-4013-8957-7031C3096653 Q26781849-49E07D0E-AB9E-40E1-88CF-43AA0351C4BA Q26782867-98007858-DF4A-46DE-8A24-1330ECF4FA49 Q26799208-DCAC0307-1583-42CD-A3B7-A7BF818266B2 Q26824514-E28D6D8A-46BD-4FF1-8974-B0D043BA6BA3 Q26864685-4BBAEDDB-665B-4E66-A50C-039569BF13E3 Q27003296-94B55018-C58B-48DD-9C18-0F96386F073D Q27005950-7B9A020C-854B-46F5-9275-1B6A16C985B1 Q27026255-111DD66E-7542-4530-A0F9-BBBBF611515D Q27301483-FAF2841A-B212-4CFC-99BB-803CAA282C2E Q27677296-00554D3B-C7B7-45F3-A863-6565F29AA2F5 Q28085041-99F510BD-6CA3-4FF6-B26F-205895C4BB97 Q28239367-2A97441C-A071-47B3-B5E7-E1F06A563CAD Q28483412-7D950FCF-2AC9-493C-8BF0-28CEF5705CD8 Q28535496-B120DB25-F1D0-47E6-ABD5-143FFDD147C1 Q28834131-F0D41823-67C4-4D0C-B4CE-C2B698D0C34D Q29306917-0DBEFDF9-1C29-4779-94E3-AA4143DF17FD Q30243906-D249617D-E7DC-414B-BE1E-279CC1F5CFB2 Q30355064-D38F3C90-D220-46E3-82E6-C96F9CBFE3D5 Q30530945-FEE4531A-E162-4108-903B-430D4876A2A5 Q30678210-E0A4A03C-4BA0-492D-A874-0D3AE4FE2203 Q30837903-4FB4EACE-E0A1-4BB3-A368-8A690D738D2B Q30995841-5E2DC122-E8AE-4EC3-AFD6-D7B83CA1A4E4 Q33556068-55707A14-E519-416A-AC50-2FFF761C5ECA Q33575494-4A0B5B64-1F60-4691-8619-BF485084D0CB Q33809556-A1E0295B-7E56-4CB7-84D8-441958900549 Q33854563-2FA1383F-3287-4C94-B0E2-006E75BCD254 Q34080446-08B43C0B-C635-4016-AD82-53EFBF2D91D4 Q34124551-097BA708-556B-40B5-94B7-A650E615DF27 Q34158629-2E8C0C3A-CBB8-42E8-A134-AEC122B1BAE5 Q34194189-7E10365A-5979-4741-87D2-C8154F7A7671 Q34321423-10B7C893-D514-4006-938C-D0F998E445C8 Q34381234-B242F711-C9E0-4070-9C18-559674C5FE03 Q34435001-5B2CD4B9-21D2-486F-837A-C3F3F1212A85 Q34508486-176308FE-43F2-446E-8518-18175900B969 Q34695396-AB39B5D2-F2AB-495D-B7DE-C2B72CBB0EC6 Q34979782-D83F0FFB-3629-4C03-A796-1D0B00C3A0A1 Q35058142-B8780CC5-F93E-4716-9421-5B2B039C56F1

P2860

Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.

http://www.wikidata.org/entity/Q35054916

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.

@ast

Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.

@en

type

label

Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.

@ast

Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.

@en

prefLabel

Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.

@ast

Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.

@en

P1433

Q35054916-C3B05F45-A663-4783-975B-0A0765ED9992

P1476

Q35054916-71DBEB33-9F61-463F-8494-C5B5FE1EF2B9

P2093

Q35054916-01BF83FE-EDB0-44E0-B468-3AF5D2E5ACF2

Q35054916-0309DA94-8527-4415-A8FD-A91ACF7B19BD

Q35054916-06F4854E-3A32-42B1-85F0-776E4D71A8FE

Q35054916-0B78CA56-4982-46B0-B3F8-692722DEF7E3

Q35054916-1883AA53-DABB-4DFA-99E3-1D0B1AB281AB

Q35054916-22A73CBE-8DB4-487B-9BBE-4DD6B8646A27

Q35054916-23B6FFD8-4765-4923-B562-56108906A597

Q35054916-285C985F-CC3B-4826-B028-EFDEFBA61CAA

Q35054916-2E8D3356-4FCB-4D83-8B5B-D5BA73C8F4BA

Q35054916-457B29BB-5E78-44F6-AF9B-925D114B0BB2

P2860

Q35054916-0C4BA942-A7BB-4BA7-ACC6-1CFEE43BF010

Q35054916-0C5063D5-0CFE-4FF7-A197-0F436294B3AE

Q35054916-14B6DCC4-1592-47BB-8BF6-9D6F86568304

Q35054916-1616EB0C-71EE-40ED-923A-241444A036EA

Q35054916-17657ECD-E967-41CB-96D0-C1628C8ECFF2

Q35054916-1B1B92F4-BDB8-48D6-9ED0-3D84EB2F88DE

Q35054916-1B663577-3CC5-470D-9027-640C3608910D

Q35054916-2012F175-3E29-4236-BEC6-90E74FC1332F

Q35054916-2632B4B5-BB5F-4AF1-8226-8E133DB859DB

Q35054916-26BEF075-D32B-4002-9EDC-3342BDB38B6C

P304

Q35054916-8B521522-ECFE-4B9E-85D4-C059A16B1D44

P31

Q35054916-A5EAE15C-D05C-44CD-98E7-EC8028E5E2DF

P356

Q35054916-CB403590-1D0B-4CC9-A9D4-164DF9A36563

P407

Q35054916-5619D77F-7E5B-40D9-BDED-851ED001B1D2

P433

Q35054916-3F651ED0-E677-47AB-B104-3BFBBC7BFDCC

P478

Q35054916-F9619BAB-C60D-43F9-83D0-45B9D58D7264

P50

Q35054916-5FF8D5B2-7525-44D6-AFB7-C4CBB66F2BB2

P577

Q35054916-9656F736-D3CE-45DE-A97E-FDC32520ABE4

P5875

Q35054916-17F51223-7DF9-4FAC-B81D-7F981EB5795D

P698

Q35054916-A49D61F3-23BF-4E3E-80E6-7774F5B425FA

P932

Q35054916-6E8BAED2-1305-4AD0-B5D3-0C8FEDF02ABA

P356

J.CELL.2011.05.020

P1433

P1476

Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.

@en

P2093

Anthony Adame

http://www.w3.org/2001/XMLSchema#string

Arash Rassoulpour

http://www.w3.org/2001/XMLSchema#string

Christina Patrick

http://www.w3.org/2001/XMLSchema#string

Daniel Zwilling

http://www.w3.org/2001/XMLSchema#string

Eric W Hsieh

http://www.w3.org/2001/XMLSchema#string

Flaviano Giorgini

http://www.w3.org/2001/XMLSchema#string

Francesca M Notarangelo

http://www.w3.org/2001/XMLSchema#string

Grit Laue

http://www.w3.org/2001/XMLSchema#string

Gunnar Flik

http://www.w3.org/2001/XMLSchema#string

Hui-Qiu Wu

http://www.w3.org/2001/XMLSchema#string

P2860

Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35

A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease.

The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications

The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease

Kynurenine and its metabolites in Alzheimer's disease patients

Mitochondrial aspartate aminotransferase: a third kynurenate-producing enzyme in the mammalian brain

Kynurenic acid concentrations are reduced in Huntington's disease cerebral cortex

Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease

Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice

Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease

P304

863-874

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.CELL.2011.05.020

http://www.w3.org/2001/XMLSchema#string

P407

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

145

http://www.w3.org/2001/XMLSchema#string

P50

Eliezer Masliah

P577

2011-06-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51190675

http://www.w3.org/2001/XMLSchema#string

P698

21640374

http://www.w3.org/2001/XMLSchema#string

P932

3118409

http://www.w3.org/2001/XMLSchema#string