The tubulin-binding agent combretastatin A-4-phosphate arrests endothelial cells in mitosis and induces mitotic cell death
about
Anti-vascular agent Combretastatin A-4-P modulates hypoxia inducible factor-1 and gene expression.Near-infrared uncaging or photosensitizing dictated by oxygen tension.Combretastatin A-4 inhibits cell growth and metastasis in bladder cancer cells and retards tumour growth in a murine orthotopic bladder tumour model.Endonuclease G mediates endothelial cell death induced by carbamylated LDL.Design and synthesis of imidazo[2,1-b]thiazole-chalcone conjugates: microtubule-destabilizing agents.Synthesis and biological evaluation of imidazo[1,5-a]pyridine-benzimidazole hybrids as inhibitors of both tubulin polymerization and PI3K/Akt pathway.Synthesis of 2-anilinopyridyl-triazole conjugates as antimitotic agents.Structurally simplified biphenyl combretastatin A4 derivatives retain in vitro anti-cancer activity dependent on mitotic arrestReview of the effects of anti-angiogenic compounds on the epiphyseal growth plate.Tumour targeting by microtubule-depolymerizing vascular disrupting agents.Tumour vascular disrupting agents: combating treatment resistance.Novel microtubule polymerization inhibitor with potent antiproliferative and antitumor activity.Microtubule depolymerizing vascular disrupting agents: novel therapeutic agents for oncology and other pathologies.Cell cycle modulatory and apoptotic effects of plant-derived anticancer drugs in clinical use or development.Design, Synthesis, and in vitro and in vivo Evaluations of (Z)-3,4,5-Trimethoxystyrylbenzenesulfonamides/sulfonates as Highly Potent Tubulin Polymerization Inhibitors.2-Anilino-3-Aroylquinolines as Potent Tubulin Polymerization Inhibitors.Combretastatin A-4 derived imidazoles show cytotoxic, antivascular, and antimetastatic effects based on cytoskeletal reorganisation.3-substituted 2-phenylimidazo[2,1-b]benzothiazoles: synthesis, anticancer activity, and inhibition of tubulin polymerization.FPTB, a novel CA-4 derivative, induces cell apoptosis of human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress pathways.Vascular effects dominate solid tumor response to treatment with combretastatin A-4-phosphate.Novel combretastatin A-4 derivative XN0502 induces cell cycle arrest and apoptosis in A549 cells.Resveratrol derivative, trans-3,5,4'-trimethoxystilbene, exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation.Evaluation of 5-hydroxy-2,3-diaryl (substituted)-cyclopent-2-en-1-ones as cis-restricted analogues of combretastatin A-4 as novel anti angiogenic and anticancer agents.The tubulin-depolymerising agent combretastatin-4 induces ectopic aster assembly and mitotic catastrophe in lung cancer cells H460.p38 MAPK, but not ERK1/2, is critically involved in the cytotoxicity of the novel vascular disrupting agent combretastatin A4.Combretastatin CA-4 and combretastatin derivative induce mitotic catastrophe dependent on spindle checkpoint and caspase-3 activation in non-small cell lung cancer cells.Antineoplastic agents. 565. Synthesis of combretastatin D-2 phosphate and dihydro-combretastatin D-2.Primary endothelial damage is the mechanism of cardiotoxicity of tubulin-binding drugs.Drug resistance reversal by combretastatin-A4 phosphate loaded with doxorubicin in polymersomes independent of angiogenesis effect.The protective role of sphingosine-1-phosphate against the action of the vascular disrupting agent combretastatin A-4 3-O-phosphate.
P2860
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P2860
The tubulin-binding agent combretastatin A-4-phosphate arrests endothelial cells in mitosis and induces mitotic cell death
description
2004 nî lūn-bûn
@nan
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
The tubulin-binding agent comb ...... and induces mitotic cell death
@ast
The tubulin-binding agent comb ...... and induces mitotic cell death
@en
type
label
The tubulin-binding agent comb ...... and induces mitotic cell death
@ast
The tubulin-binding agent comb ...... and induces mitotic cell death
@en
prefLabel
The tubulin-binding agent comb ...... and induces mitotic cell death
@ast
The tubulin-binding agent comb ...... and induces mitotic cell death
@en
P2093
P2860
P1476
The tubulin-binding agent comb ...... and induces mitotic cell death
@en
P2093
Anna Stratford
Chryso Kanthou
Gillian Tozer
Olga Greco
Omar Benzakour
Richard Knight
P2860
P304
P356
10.1016/S0002-9440(10)63398-6
P407
P577
2004-10-01T00:00:00Z