Extraordinary rates of transition metal ion-mediated ribozyme catalysis
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Structure-based search reveals hammerhead ribozymes in the human microbiomeSolvent Structure and Hammerhead Ribozyme CatalysisKinetic and Structural Characterization of Dihydrofolate Reductase from Streptococcus pneumoniaeActive-Site Monovalent Cations Revealed in a 1.55-Å-Resolution Hammerhead Ribozyme StructureHammerhead redux: does the new structure fit the old biochemical data?Ca2+ induces the formation of two distinct subpopulations of group II intron molecules.Enhanced product stability in the hammerhead ribozyme.Metal ions: supporting actors in the playbook of small ribozymes.Topological rearrangement yields structural stabilization and interhelical distance constraints in the Kin.46 self-phosphorylating ribozyme.Conformational heterogeneity and the determinants of tertiary stabilization in the hammerhead ribozyme from Dolichopoda cave crickets.Evidence for proton transfer in the rate-limiting step of a fast-cleaving Varkud satellite ribozyme.Folding of the hammerhead ribozyme: pyrrolo-cytosine fluorescence separates core folding from global folding and reveals a pH-dependent conformational change.Distinct reaction pathway promoted by non-divalent-metal cations in a tertiary stabilized hammerhead ribozyme.The importance of peripheral sequences in determining the metal selectivity of an in vitro-selected Co(2+) -dependent DNAzyme.Evidence that binding of C5 protein to P RNA enhances ribozyme catalysis by influencing active site metal ion affinity.In vitro evolution of distinct self-cleaving ribozymes in diverse environments.Minimal and extended hammerheads utilize a similar dynamic reaction mechanism for catalysis.Two Divalent Metal Ions and Conformational Changes Play Roles in the Hammerhead Ribozyme Cleavage Reaction.A versatile cis-blocking and trans-activation strategy for ribozyme characterization.Bridging the gap between theory and experiment to derive a detailed understanding of hammerhead ribozyme catalysis.Two Active Site Divalent Ions in the Crystal Structure of the Hammerhead Ribozyme Bound to a Transition State AnalogueLewis acid catalysis of phosphoryl transfer from a copper(II)-NTP complex in a kinase ribozyme.Role of Mg2+ in hammerhead ribozyme catalysis from molecular simulationMetal ion specificities for folding and cleavage activity in the Schistosoma hammerhead ribozymeInsight into the role of Mg in hammerhead ribozyme catalysis from X-ray crystallography and molecular dynamics simulation.A self-cleaving DNA enzyme modified with amines, guanidines and imidazoles operates independently of divalent metal cations (M2+).Threshold occupancy and specific cation binding modes in the hammerhead ribozyme active site are required for active conformation.Catalytic diversity of extended hammerhead ribozymesActivity, folding and Z-DNA formation of the 8-17 DNAzyme in the presence of monovalent ions.Nucleic acid catalysis: metals, nucleobases, and other cofactors.Divalent Metal Ion Activation of a Guanine General Base in the Hammerhead Ribozyme: Insights from Molecular Simulations.Long-range tertiary interactions in single hammerhead ribozymes bias motional sampling toward catalytically active conformationsThe identity of the nucleophile substitution may influence metal interactions with the cleavage site of the minimal hammerhead ribozyme.The ionic environment determines ribozyme cleavage rate by modulation of nucleobase pK aRe-characterization of hammerhead ribozymes as molecular tools for intermolecular RNA cleavage.Protein-inspired modified DNAzymes: dramatic effects of shortening side-chain length of 8-imidazolyl modified deoxyadenosines in selecting RNaseA mimicking DNAzymes.
P2860
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P2860
Extraordinary rates of transition metal ion-mediated ribozyme catalysis
description
2006 nî lūn-bûn
@nan
2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Extraordinary rates of transition metal ion-mediated ribozyme catalysis
@ast
Extraordinary rates of transition metal ion-mediated ribozyme catalysis
@en
type
label
Extraordinary rates of transition metal ion-mediated ribozyme catalysis
@ast
Extraordinary rates of transition metal ion-mediated ribozyme catalysis
@en
prefLabel
Extraordinary rates of transition metal ion-mediated ribozyme catalysis
@ast
Extraordinary rates of transition metal ion-mediated ribozyme catalysis
@en
P2860
P356
P1433
P1476
Extraordinary rates of transition metal ion-mediated ribozyme catalysis
@en
P2093
Donald H Burke
Manami Roychowdhury-Saha
P2860
P304
P356
10.1261/RNA.128906
P407
P577
2006-08-15T00:00:00Z