Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. - Wikidata - awgldk - TriplyDB

Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis.

Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis.

http://www.wikidata.org/entity/Q35058315

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Dopamine release in the basal ganglia Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)Synaptic vesicle trafficking and Parkinson's disease LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25 Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins.Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2 Versatile Structures of α-Synuclein Dynamic structural flexibility of α-synuclein Alpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons Disease Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways Disease-modifying therapeutic directions for Lewy-Body dementias Is Cell Death Primary or Secondary in the Pathophysiology of Idiopathic Parkinson's Disease?LRRK2 as a Potential Genetic Modifier of Synucleinopathies: Interlacing the Two Major Genetic Factors of Parkinson's Disease Intrabodies as neuroprotective therapeutics Function and dysfunction of α-synuclein: probing conformational changes and aggregation by single molecule fluorescence Synaptic dysfunction and septin protein family members in neurodegenerative diseases Synucleins antagonize endoplasmic reticulum function to modulate dopamine transporter trafficking Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease.Characterization of cognitive deficits in rats overexpressing human alpha-synuclein in the ventral tegmental area and medial septum using recombinant adeno-associated viral vectors A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons.Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function Impaired c-Fos and polo-like kinase 2 induction in the limbic system of fear-conditioned α-synuclein transgenic mice The Synaptic Function of α-Synuclein Membrane remodeling and mechanics: Experiments and simulations of α-Synuclein Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance Alpha-Synuclein in Parkinson's Disease: From Pathogenetic Dysfunction to Potential Clinical Application The phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's disease Reducing synuclein accumulation improves neuronal survival after spinal cord injury Mutation in the SYNJ1 gene associated with autosomal recessive, early-onset Parkinsonism Neurodegenerative disease and adult neurogenesis Dopamine and paraquat enhance α-synuclein-induced alterations in membrane conductance A system for performing high throughput assays of synaptic function αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease Alpha-synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice Total α-synuclein levels in human blood cells, CSF, and saliva determined by a lipid-ELISA.

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P2860

Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis.

http://www.wikidata.org/entity/Q35058315

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2010 nî lūn-bûn

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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2010 թվականի հունվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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name

Increased expression of alpha- ...... eclustering after endocytosis.

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Increased expression of alpha- ...... eclustering after endocytosis.

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Increased expression of alpha- ...... eclustering after endocytosis.

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Increased expression of alpha- ...... eclustering after endocytosis.

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Bibiana Onoa

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Farrukh A Chaudhry

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Ken Nakamura

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Robert H Edwards

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Roger A Nicoll

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Victoria Berge

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P2860

Evidence that alpha-synuclein functions as a negative regulator of Ca(++)-dependent alpha-granule release from human platelets

Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions

Membrane fusion: grappling with SNARE and SM proteins

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

alpha-Synuclein locus triplication causes Parkinson's disease

Staging of brain pathology related to sporadic Parkinson's disease

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

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