Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
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Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recyclingRecoupling the cardiac nitric oxide synthases: tetrahydrobiopterin synthesis and recyclingNitric oxide synthases in heart failurePrinciples of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in diseaseTetrahydrobiopterin Supplementation: Elevation of Tissue Biopterin Levels Accompanied by a Relative Increase in Dihydrobiopterin in the Blood and the Role of Probenecid-Sensitive Uptake in Scavenging Dihydrobiopterin in the Liver and Kidney of RatsTetrahydrobiopterin activates brown adipose tissue and regulates systemic energy metabolism.Hypoxia and reoxygenation induce endothelial nitric oxide synthase uncoupling in endothelial cells through tetrahydrobiopterin depletion and S-glutathionylation.Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease.Endothelial Nitric Oxide Synthase-Derived Nitric Oxide Prevents Dihydrofolate Reductase Degradation via Promoting S-Nitrosylation.Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.Tackling endothelial dysfunction by modulating NOS uncoupling: new insights into its pathogenesis and therapeutic possibilities.The mechanisms and physiological relevance of glycocalyx degradation in hepatic ischemia/reperfusion injury.ROS signaling and redox biology in endothelial cells.Cell type-specific recycling of tetrahydrobiopterin by dihydrofolate reductase explains differential effects of 7,8-dihydrobiopterin on endothelial nitric oxide synthase uncoupling.Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers.α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease.Examining a role for PKG Iα oxidation in the pathogenesis of cardiovascular dysfunction during diet-induced obesity.Intestinal microbiota as a tetrahydrobiopterin exogenous source in hph-1 mice.Uncoupling endothelial nitric oxide synthase is ameliorated by green tea in experimental diabetes by re-establishing tetrahydrobiopterin levelsOrganic anion transporters, OAT1 and OAT3, are crucial biopterin transporters involved in bodily distribution of tetrahydrobiopterin and exclusion of its excess.The Role of Nrf2 in Cardiovascular Function and Disease.Tetrahydrobiopterin deficiency induces gastroparesis in newborn mice.The Interactions Between Kynurenine, Folate, Methionine and Pteridine Pathways in Obesity.Exercise Amaliorates Metabolic Disturbances and Oxidative Stress in Diabetic Cardiomyopathy: Possible Underlying Mechanisms.Tetrahydrobiopterin: a vascular redox target to improve endothelial function.Unintended consequences of inhibiting dihydrofolate reductase through folic acid supplementation: inattentive-type attention deficit hyperactivity disorder and ASD connections.Serum Phenylalanine, Tyrosine, and their Ratio in Acute Ischemic Stroke: on the Trail of a Biomarker?The Inhibitory Effect of Ojeoksan on Early and Advanced Atherosclerosis
P2860
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P2860
Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Dihydrofolate reductase protec ...... etrahydrobiopterin deficiency.
@ast
Dihydrofolate reductase protec ...... etrahydrobiopterin deficiency.
@en
type
label
Dihydrofolate reductase protec ...... etrahydrobiopterin deficiency.
@ast
Dihydrofolate reductase protec ...... etrahydrobiopterin deficiency.
@en
prefLabel
Dihydrofolate reductase protec ...... etrahydrobiopterin deficiency.
@ast
Dihydrofolate reductase protec ...... etrahydrobiopterin deficiency.
@en
P2860
P1476
Dihydrofolate reductase protec ...... etrahydrobiopterin deficiency.
@en
P2093
Ashley B Hale
P2860
P304
P356
10.1016/J.FREERADBIOMED.2011.03.010
P577
2011-03-12T00:00:00Z