Metabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys. - Wikidata - awgldk - TriplyDB

Metabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys.

Metabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys.

http://www.wikidata.org/entity/Q35065682

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Emerging preclinical pharmacological targets for Parkinson's disease Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise Biochemical premotor biomarkers for Parkinson's disease Basal ganglia activity patterns in parkinsonism and computational modeling of their downstream effects Localization and function of dopamine receptors in the subthalamic nucleus of normal and parkinsonian monkeys.Reduced noradrenergic innervation of ventral midbrain dopaminergic cell groups and the subthalamic nucleus in MPTP-treated parkinsonian monkeys.In vivo measures of nigrostriatal neuronal response to unilateral MPTP treatment.PET analysis of dopaminergic neurodegeneration in relation to immobility in the MPTP-treated common marmoset, a model for Parkinson's disease.Parkinson's disease therapeutics: new developments and challenges since the introduction of levodopa.Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and colocalization with the metabotropic glutamate receptor 5 in the striatum.The primate thalamostriatal systems: Anatomical organization, functional roles and possible involvement in Parkinson's disease.Propagated but Topologically Distributed Forebrain Neurons Expressing Alpha-Synuclein in Aged Macaques Proteomic profiling in MPTP monkey model for early Parkinson disease biomarker discovery Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications.Combining Diffusion Tensor Imaging and Susceptibility Weighted Imaging on the Substantia Nigra of 1-Methyl-4-Phenyl-1, 2, 3, 6-Tetrahydropyridine (MPTP)-induced Rhesus Monkey Model of Parkinson's Disease.Reduced cortical innervation of the subthalamic nucleus in MPTP-treated parkinsonian monkeys.Neuronal loss in the caudal intralaminar thalamic nuclei in a primate model of Parkinson's disease.Targeting glutamate receptors to tackle the pathogenesis, clinical symptoms and levodopa-induced dyskinesia associated with Parkinson's disease.Therapeutic potential of targeting metabotropic glutamate receptors for Parkinson's disease.Levodopa-induced dyskinesias in Parkinson's disease: emerging treatments Therapeutic potential of targeting glutamate receptors in Parkinson's disease.Mavoglurant as a treatment for Parkinson's disease.Chronic MPTP administration regimen in monkeys: a model of dopaminergic and non-dopaminergic cell loss in Parkinson's disease.The Role of Dopamine in Inflammation-Associated Depression: Mechanisms and Therapeutic Implications.Inflammation Effects on Motivation and Motor Activity: Role of Dopamine.mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Role of the pedunculopontine nucleus in controlling gait and sleep in normal and parkinsonian monkeys.Non-human primate models of PD to test novel therapies.Basal ganglia, movement disorders and deep brain stimulation: advances made through non-human primate research.Sub-synaptic localization of Cav3.1 T-type calcium channels in the thalamus of normal and parkinsonian monkeys.Imaging the role of inflammation in mood and anxiety-related disorders.Nonhuman Primate Models of Neurodegenerative Disorders.Sparing of orexin-A and orexin-B neurons in the hypothalamus and of orexin fibers in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated macaques.Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation.Can Interactions Between α-Synuclein, Dopamine and Calcium Explain Selective Neurodegeneration in Parkinson's Disease?Neurotoxic Agent-Induced Injury in Neurodegenerative Disease Model: Focus on Involvement of Glutamate Receptors

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P2860

Metabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys.

http://www.wikidata.org/entity/Q35065682

description

2011 nî lūn-bûn

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2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2011 թվականի հուլիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Metabotropic glutamate recepto ...... ation in MPTP-treated monkeys.

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Metabotropic glutamate recepto ...... ation in MPTP-treated monkeys.

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Metabotropic glutamate recepto ...... ration in MPTP-treated monkeys

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David Alagille

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Gilles Tamagnan

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Gunasingh J Masilamoni

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James W Bogenpohl

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John R Votaw

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Thomas Wichmann

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Yoland Smith

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P2860

Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part II: physiological and pharmacological manipulations and pathological alterations of locus coeruleus activity in humans

A pilot open label, single dose trial of fenobam in adults with fragile X syndrome.

Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein.

Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures

Staging of brain pathology related to sporadic Parkinson's disease

Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins

Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

Metabotropic glutamate receptors in the basal ganglia motor circuit

Glutamate-based therapeutic approaches: clinical trials with NMDA antagonists

Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors

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2057-2073

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scholarly article

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10.1093/BRAIN/AWR137

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P433

Pt 7

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134

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Kristen M Delevich

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2011-07-01T00:00:00Z

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51250039

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21705423

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