Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors
about
Flexible modulation of agonist efficacy at the human A3 adenosine receptor by the imidazoquinoline allosteric enhancer LUF6000Positive allosteric modulation of metabotropic glutamate 5 (mGlu5) receptors reverses N-Methyl-D-aspartate antagonist-induced alteration of neuronal firing in prefrontal cortexPositive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-leadSynthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs)Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in ratsNorbin is an endogenous regulator of metabotropic glutamate receptor 5 signalingMolecular targets for antiepileptic drug developmentThe Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys.mGluR5 has a critical role in inhibitory learning.Molecular targets for treating cognitive dysfunction in schizophrenia.Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators.Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5).Interaction of N-methyl-D-aspartate and group 5 metabotropic glutamate receptors on behavioral flexibility using a novel operant set-shift paradigm.Iterative experimental and virtual high-throughput screening identifies metabotropic glutamate receptor subtype 4 positive allosteric modulators.Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4).Positive allosteric modulators of type 5 metabotropic glutamate receptors (mGluR5) and their therapeutic potential for the treatment of CNS disorders.Glutamatergic targets for enhancing extinction learning in drug addictionMetabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys.A trial of D-cycloserine to treat stereotypies in older adolescents and young adults with autism spectrum disorderParkinson's disease therapeutics: new developments and challenges since the introduction of levodopa.Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model.Progress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).Metabotropic glutamate receptor 4 in the basal ganglia of parkinsonian monkeys: ultrastructural localization and electrophysiological effects of activation in the striatopallidal complex.Effects of the mGluR2/3 agonist LY379268 and the mGluR5 antagonist MPEP on handling-induced convulsions during ethanol withdrawal in mice.Group I mGluRs evoke K-ATP current by intracellular Ca2+ mobilization in rat subthalamus neuronsRecent advances in the development of novel pharmacological agents for the treatment of cognitive impairments in schizophrenia.Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome.mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo.Metabotropic glutamate 7 (mGlu7) receptor: a target for medication development for the treatment of cocaine dependence.Metabotropic glutamate receptor ligands as potential therapeutics for addictionmGluR4-positive allosteric modulation as potential treatment for Parkinson's disease.Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential.Resveratrol modulates astroglial functions: neuroprotective hypothesis.Hurdles in Basic Science TranslationmGluR2-Positive allosteric modulators: Therapeutic potential for treating cocaine abuse?In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression.Quantitative analysis reveals multiple mechanisms of allosteric modulation of the mGlu5 receptor in rat astroglia.Allosteric modulators: an emerging concept in drug discovery.Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy.Co-application of the GABAB receptor agonist, baclofen, and the mGlu receptor agonist, L-CCG-I, facilitates [(3)H]GABA release from rat cortical nerve endings.
P2860
Q21262008-9BE605AA-02C7-49FD-A326-007E2A8A6422Q24602550-7061B815-5C93-4A6D-BAB1-2725016C0AFAQ24614930-64B441AF-74F6-4DCB-9188-6E72AEF565CDQ24650602-6E438B62-D2E5-4E01-922B-19FFD1C8586FQ24652668-76B4C683-04FF-4BBC-ACF4-C628B1B8672CQ24655546-854AF716-00FC-4105-94FC-16599A9ACD94Q24683346-E2141602-8056-46CC-9D5D-6E1537E9BE63Q27325802-4A8C2278-8473-437D-B7BF-2375A4FFEC87Q30486477-FEF10BA2-363A-406F-9DDB-6E88BA1E61ACQ30491310-D56E812B-CB66-4985-98D7-F901824F04A0Q33369679-B41D2389-6337-481E-987C-6F47BCBB727BQ33769874-ABDFE300-54F9-4976-B8FC-555A07C5B2B0Q34021713-CCFA64BB-E75F-4F46-A262-186A51091EBAQ34271873-B69CCCE5-88DB-401C-9D4B-C785AD1E554EQ34522043-965DC138-7E69-45BE-84FB-54E013FF1666Q34761363-43FB6846-6000-4F9A-828A-638DD8AE6154Q34829339-6AA49D68-5B0E-431E-8FAB-82E4200112E8Q35065682-0A767D0A-EC50-40FB-84D5-72769AF25464Q35162921-A73A9DAD-B929-40EA-A7E7-32AE6DBA8C4BQ35614156-8B496872-CBAA-4D76-BBAD-27218642DD59Q35988776-E03263DB-6CCC-4A39-9953-9D6B07A86929Q36015452-C954FAB4-4F16-44ED-A8FD-2061FEA6E3F6Q36374309-9B4EF115-6452-4922-84C4-F2F6E10FF82CQ36662527-F3EA3F4E-4ECA-4890-B342-F306522BC76BQ36717134-C446632B-843F-43FB-87D1-6550520D1FD9Q36886717-C70A858B-9846-45DE-8776-B6515DA90D9FQ37059491-43A8D06F-F932-4967-A9E0-1C3FADFF47D2Q37061609-901A63A1-1C6A-4C76-AA9D-8C67FCF0D2E3Q37103693-3BABA243-22D4-4B21-944C-817FEC40E6A3Q37280041-7F9CAD60-CBE2-4A60-B1C3-40AE15E3F826Q37693720-C1F23E16-C3DC-4F7B-B084-C167E2881D82Q37773480-E2088403-B9A3-407A-BFCB-6DF9DBB03490Q37831933-91EF0ADB-B9C0-40C3-A39A-C277EB7A985CQ41037577-D506A3C7-57A4-4671-B36B-A7D7A9A19195Q41819578-919B48EC-755C-4CCB-81E4-C24827F12D2AQ41843398-3ED7AACA-BC57-44EB-B0E9-80BEC87D7C55Q41864251-3F49CF49-333E-4D2F-AB72-5C2BEE2A237BQ42097244-37AB8878-ACE9-45F6-A449-5D1952702061Q42145142-6F09A1DB-08D9-4A29-8116-2317C8DC909EQ42440837-7B33C26C-D9EF-4740-81BD-AE99D86D005C
P2860
Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Glutamate-based therapeutic ap ...... tabotropic glutamate receptors
@ast
Glutamate-based therapeutic ap ...... tabotropic glutamate receptors
@en
Glutamate-based therapeutic ap ...... tabotropic glutamate receptors
@nl
type
label
Glutamate-based therapeutic ap ...... tabotropic glutamate receptors
@ast
Glutamate-based therapeutic ap ...... tabotropic glutamate receptors
@en
Glutamate-based therapeutic ap ...... tabotropic glutamate receptors
@nl
prefLabel
Glutamate-based therapeutic ap ...... tabotropic glutamate receptors
@ast
Glutamate-based therapeutic ap ...... tabotropic glutamate receptors
@en
Glutamate-based therapeutic ap ...... tabotropic glutamate receptors
@nl
P1476
Glutamate-based therapeutic ap ...... tabotropic glutamate receptors
@en
P2093
Michael J Marino
P Jeffrey Conn
P304
P356
10.1016/J.COPH.2005.09.006
P407
P577
2006-02-01T00:00:00Z