Induction of utrophin gene expression by heregulin in skeletal muscle cells: role of the N-box motif and GA binding protein.
about
Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophinYEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factorsExpression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signalingCdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junctionTranslational regulation of utrophin by miRNAsEts-2 repressor factor silences extrasynaptic utrophin by N-box mediated repression in skeletal muscle.Regulation and functional significance of utrophin expression at the mammalian neuromuscular synapse.Ets target genes: past, present and future.Expression of mutant Ets protein at the neuromuscular synapse causes alterations in morphology and gene expressionHarnessing the potential of dystrophin-related proteins for ameliorating Duchenne's muscular dystrophy.Neuregulin induces the expression of transcription factors and myosin heavy chains typical of muscle spindles in cultured human muscle.A cell-based high-throughput screening assay for posttranscriptional utrophin upregulation.The agrin/muscle-specific kinase pathway: new targets for autoimmune and genetic disorders at the neuromuscular junction.High throughput screening in duchenne muscular dystrophy: from drug discovery to functional genomicsTargeting artificial transcription factors to the utrophin A promoter: effects on dystrophic pathology and muscle function.Regulation of the Hsp90-binding immunophilin, cyclophilin 40, is mediated by multiple sites for GA-binding protein (GABP).Staufen1 regulates diverse classes of mammalian transcripts.Muscle-regulated expression and determinants for neuromuscular junctional localization of the mouse RIalpha regulatory subunit of cAMP-dependent protein kinase.Distinct regions in the 3' untranslated region are responsible for targeting and stabilizing utrophin transcripts in skeletal muscle cells.Modulation of utrophin A mRNA stability in fast versus slow muscles via an AU-rich element and calcineurin signaling.Heregulin ameliorates the dystrophic phenotype in mdx mice.Sarcolipin retention in the endoplasmic reticulum depends on its C-terminal RSYQY sequence and its interaction with sarco(endo)plasmic Ca(2+)-ATPases.Progress in therapy for Duchenne muscular dystrophy.Duchenne muscular dystrophy drug discovery - the application of utrophin promoter activation screening.Postsynaptic chromatin is under neural control at the neuromuscular junction.Identification of a crucial site for synoviolin expression.Promoter cloning and characterization of the anti-vascular proliferation gene, R-ras: role of Ets- and Sp-binding motifs.The role of basal and myogenic factors in the transcriptional activation of utrophin promoter A: implications for therapeutic up-regulation in Duchenne muscular dystrophy.The cleavage of HuR interferes with its transportin-2-mediated nuclear import and promotes muscle fiber formation.Expression of the utrophin gene during myogenic differentiation.Phosphorylation-elicited quaternary changes of GA binding protein in transcriptional activation.The utrophin gene is transcriptionally up-regulated in regenerating muscle.IGF-II ameliorates the dystrophic phenotype and coordinately down-regulates programmed cell death.Utrophin transcription is activated by an intronic enhancer.Heregulin-induced epigenetic regulation of the utrophin-A promoter.Alterations in dystrophin and utrophin expression parallel the reorganization of GABAergic synapses in a mouse model of temporal lobe epilepsy.Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells.Activation of p38 signaling increases utrophin A expression in skeletal muscle via the RNA-binding protein KSRP and inhibition of AU-rich element-mediated mRNA decay: implications for novel DMD therapeutics.Metabolic profiles of dystrophin and utrophin expression in mouse models of Duchenne muscular dystrophy.Role of intronic E- and N-box motifs in the transcriptional induction of the acetylcholinesterase gene during myogenic differentiation.
P2860
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P2860
Induction of utrophin gene expression by heregulin in skeletal muscle cells: role of the N-box motif and GA binding protein.
description
1999 nî lūn-bûn
@nan
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Induction of utrophin gene exp ...... motif and GA binding protein.
@ast
Induction of utrophin gene exp ...... motif and GA binding protein.
@en
type
label
Induction of utrophin gene exp ...... motif and GA binding protein.
@ast
Induction of utrophin gene exp ...... motif and GA binding protein.
@en
prefLabel
Induction of utrophin gene exp ...... motif and GA binding protein.
@ast
Induction of utrophin gene exp ...... motif and GA binding protein.
@en
P2093
P2860
P356
P1476
Induction of utrophin gene exp ...... motif and GA binding protein.
@en
P2093
Changeux JP
Gramolini AO
Schaeffer L
Tinsley JM
P2860
P304
P356
10.1073/PNAS.96.6.3223
P407
P577
1999-03-01T00:00:00Z