Attenuated Francisella novicida transposon mutants protect mice against wild-type challenge. - Wikidata - awgldk - TriplyDB

Attenuated Francisella novicida transposon mutants protect mice against wild-type challenge.

Attenuated Francisella novicida transposon mutants protect mice against wild-type challenge.

http://www.wikidata.org/entity/Q35073798

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Comparative review of Francisella tularensis and Francisella novicida The complex amino acid diet of Francisella in infected macrophages Mutations of Francisella novicida that alter the mechanism of its phagocytosis by murine macrophages Components of the type six secretion system are substrates of Francisella tularensis Schu S4 DsbA-like FipB protein Characterization of Francisella tularensis Schu S4 defined mutants as live-attenuated vaccine candidates Production of outer membrane vesicles and outer membrane tubes by Francisella novicida.Rationally designed tularemia vaccines.Identification of an essential Francisella tularensis subsp. tularensis virulence factor.Francisella tularensis subsp. tularensis Schu S4 disulfide bond formation protein B, but not an RND-type efflux pump, is required for virulence Identification of genes contributing to the virulence of Francisella tularensis SCHU S4 in a mouse intradermal infection model A comprehensive transposon mutant library of Francisella novicida, a bioweapon surrogate Global transcriptional response to mammalian temperature provides new insight into Francisella tularensis pathogenesis.Glutathione provides a source of cysteine essential for intracellular multiplication of Francisella tularensis.Identification of trkH, encoding a potassium uptake protein required for Francisella tularensis systemic dissemination in mice.Whole-genome sequencing reveals distinct mutational patterns in closely related laboratory and naturally propagated Francisella tularensis strains Differential ability of novel attenuated targeted deletion mutants of Francisella tularensis subspecies tularensis strain SCHU S4 to protect mice against aerosol challenge with virulent bacteria: effects of host background and route of immunization.Francisella tularensis Schu S4 O-antigen and capsule biosynthesis gene mutants induce early cell death in human macrophages.Pivotal role of the Francisella tularensis heat-shock sigma factor RpoH.Characterization of the pathogenicity island protein PdpA and its role in the virulence of Francisella novicida Directed screen of Francisella novicida virulence determinants using Drosophila melanogaster.Macrophage replication screen identifies a novel Francisella hydroperoxide resistance protein involved in virulence.IglC and PdpA are important for promoting Francisella invasion and intracellular growth in epithelial cells Mucosal immunization with live attenuated Francisella novicida U112ΔiglB protects against pulmonary F. tularensis SCHU S4 in the Fischer 344 rat model Identification of Francisella novicida mutants that fail to induce prostaglandin E(2) synthesis by infected macrophages.Type A Francisella tularensis acid phosphatases contribute to pathogenesis.Use of a capture-based pathogen transcript enrichment strategy for RNA-Seq analysis of the Francisella tularensis LVS transcriptome during infection of murine macrophages.Francisella-arthropod vector interaction and its role in patho-adaptation to infect mammals The francisella intracellular life cycle: toward molecular mechanisms of intracellular survival and proliferation.Francisella tularensis metabolism and its relation to virulence.The capBCA Locus is Required for Intracellular Growth of Francisella tularensis LVS.Vaccines against tularemia.Discovery of a role for Hsp82 in Histoplasma virulence through a quantitative screen for macrophage lethality.Francisella novicida pathogenicity island encoded proteins were secreted during infection of macrophage-like cells Preclinical testing of a vaccine candidate against tularemia.Francisella tularensis uses cholesterol and clathrin-based endocytic mechanisms to invade hepatocytes.In vivo negative selection screen identifies genes required for Francisella virulence Genome-wide identification of Francisella tularensis virulence determinants The biochemical properties of the Francisella pathogenicity island (FPI)-encoded proteins IglA, IglB, IglC, PdpB and DotU suggest roles in type VI secretion.Identification of Francisella tularensis Himar1-based transposon mutants defective for replication in macrophages The Francisella tularensis FabI enoyl-acyl carrier protein reductase gene is essential to bacterial viability and is expressed during infection.

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Attenuated Francisella novicida transposon mutants protect mice against wild-type challenge.

http://www.wikidata.org/entity/Q35073798

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2006 nî lūn-bûn

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2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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Attenuated Francisella novicid ...... e against wild-type challenge.

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Attenuated Francisella novicid ...... e against wild-type challenge.

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Attenuated Francisella novicid ...... e against wild-type challenge.

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Attenuated Francisella novicid ...... e against wild-type challenge.

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Attenuated Francisella novicid ...... e against wild-type challenge.

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Attenuated Francisella novicid ...... e against wild-type challenge.

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Infection and Immunity

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Attenuated Francisella novicid ...... e against wild-type challenge.

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P2093

Briana Kozlowicz

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Fred Heffron

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Lidia Crosa

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Rebecca Tempel

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Xin-He Lai

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P2860

The complete genome sequence of Francisella tularensis, the causative agent of tularemia

Construction of a reporter plasmid for screening in vivo promoter activity in Francisella tularensis.

Sequencing of the Francisella tularensis strain Schu 4 genome reveals the shikimate and purine metabolic pathways, targets for the construction of a rationally attenuated auxotrophic vaccine.

Genome-wide DNA microarray analysis of Francisella tularensis strains demonstrates extensive genetic conservation within the species but identifies regions that are unique to the highly virulent F. tularensis subsp. tularensis

Salmonella pathogenicity island 1-independent induction of apoptosis in infected macrophages by Salmonella enterica serotype typhimurium.

Intranasal vaccination induces protective immunity against intranasal infection with virulent Francisella tularensis biovar A

Tularemia as a biological weapon: medical and public health management.

Oxygen- and growth rate-dependent regulation of Escherichia coli fumarase (FumA, FumB, and FumC) activity.

Identification of new secreted effectors in Salmonella enterica serovar Typhimurium

Protein disulfide bond formation in prokaryotes.

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5095-5105

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10.1128/IAI.00598-06

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9

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74

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1594869

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