Co-expression of GRK2 reveals a novel conformational state of the µ-opioid receptor - Wikidata - awgldk - TriplyDB

Co-expression of GRK2 reveals a novel conformational state of the µ-opioid receptor

Co-expression of GRK2 reveals a novel conformational state of the µ-opioid receptor

http://www.wikidata.org/entity/Q35078148

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Structure-based discovery of opioid analgesics with reduced side effects.Biased ligand quantification in drug discovery: from theory to high throughput screening to identify new biased μ opioid receptor agonists A Practical Guide to Approaching Biased Agonism at G Protein Coupled Receptors.Designing Safer Analgesics via μ-Opioid Receptor Pathways.Inhibition of β-ARK1 Ameliorates Morphine-induced Tolerance and Hyperalgesia Via Modulating the Activity of Spinal NMDA Receptors.

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Co-expression of GRK2 reveals a novel conformational state of the µ-opioid receptor

http://www.wikidata.org/entity/Q35078148

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2013 nî lūn-bûn

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2013 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年学术文章

@wuu

2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年學術文章

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Co-expression of GRK2 reveals a novel conformational state of the µ-opioid receptor

@ast

Co-expression of GRK2 reveals a novel conformational state of the µ-opioid receptor

@en

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label

Co-expression of GRK2 reveals a novel conformational state of the µ-opioid receptor

@ast

Co-expression of GRK2 reveals a novel conformational state of the µ-opioid receptor

@en

prefLabel

Co-expression of GRK2 reveals a novel conformational state of the µ-opioid receptor

@ast

Co-expression of GRK2 reveals a novel conformational state of the µ-opioid receptor

@en

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JOURNAL.PONE.0083691

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Co-expression of GRK2 reveals a novel conformational state of the µ-opioid receptor

@en

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Gordon McMurray

http://www.w3.org/2001/XMLSchema#string

Mellissa Clark

http://www.w3.org/2001/XMLSchema#string

Sarah A Nickolls

http://www.w3.org/2001/XMLSchema#string

Sian Humphreys

http://www.w3.org/2001/XMLSchema#string

P2860

GRK2: multiple roles beyond G protein-coupled receptor desensitization

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Enhanced morphine analgesia in mice lacking beta-arrestin 2

Morphine promotes rapid, arrestin-dependent endocytosis of mu-opioid receptors in striatal neurons

Specific G protein activation and mu-opioid receptor internalization caused by morphine, DAMGO and endomorphin I

Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.

Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors.

A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine.

Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor

Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

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e83691

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scholarly article

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10.1371/JOURNAL.PONE.0083691

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3869807

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