Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion - Wikidata - awgldk - TriplyDB

Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion

Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion

http://www.wikidata.org/entity/Q35080356

about

Small-molecule inhibitors of dengue-virus entry Potent D-peptide inhibitors of HIV-1 entry Protease-resistant peptide design-empowering nature's fragile warriors against HIV A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies Viral membrane fusion Structures and Mechanisms of Viral Membrane Fusion Proteins: Multiple Variations on a Common Theme Structure of the HIV-1 gp41 Membrane-Proximal Ectodomain Region in a Putative Prefusion Conformation † , ‡Structural and biological mimicry of protein surface recognition by / -peptide foldamers Design of a Potent D-Peptide HIV-1 Entry Inhibitor with a Strong Barrier to Resistance Broad Distribution of Energetically Important Contacts across an Extended Protein Interface Enhancement of α-Helix Mimicry by an α/β-Peptide Foldamer via Incorporation of a Dense Ionic Side-Chain Array Internal dynamics of the homotrimeric HIV-1 viral coat protein gp41 on multiple time scales A novel fluorescence intensity screening assay identifies new low-molecular-weight inhibitors of the gp41 coiled-coil domain of human immunodeficiency virus type 1 Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses.Stable extended human immunodeficiency virus type 1 gp41 coiled coil as an effective target in an assay for high-affinity fusion inhibitors.Contribution of light chain residues to high affinity binding in an HIV-1 antibody explored by combinatorial scanning mutagenesis Origins of resistance to the HIVgp41 viral entry inhibitor T20.Vaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates.A low-molecular-weight entry inhibitor of both CCR5- and CXCR4-tropic strains of human immunodeficiency virus type 1 targets a novel site on gp41 Synthetic Fab fragments that bind the HIV-1 gp41 heptad repeat regions.Dissection of SNARE-driven membrane fusion and neuroexocytosis by wedging small hydrophobic molecules into the SNARE zipper Inhibition of HIV Entry by Targeting the Envelope Transmembrane Subunit gp41.Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactions Side chain requirements for affinity and specificity in D5, an HIV-1 antibody derived from the VH1-69 germline segment Inhibition of adenovirus replication by a trisubstituted piperazin-2-one derivative.Biochemistry and biophysics of HIV-1 gp41 - membrane interactions and implications for HIV-1 envelope protein mediated viral-cell fusion and fusion inhibitor design High-Throughput HIV-Cell Fusion Assay for Discovery of Virus Entry Inhibitors Targeting HIV-1 gp41-induced fusion and pathogenesis for anti-viral therapy Identification of a specific region in the e1 fusion protein involved in zinc inhibition of semliki forest virus fusion.A fluorescence polarization assay using an engineered human respiratory syncytial virus F protein as a direct screening platform Screening and Functional Profiling of Small-Molecule HIV-1 Entry and Fusion Inhibitors.Development of Small-molecule HIV Entry Inhibitors Specifically Targeting gp120 or gp41 Design of Small Molecules with HIV Fusion Inhibitory Property Based on Gp41 Interaction Assay SC29EK, a peptide fusion inhibitor with enhanced alpha-helicity, inhibits replication of human immunodeficiency virus type 1 mutants resistant to enfuvirtide Divide and conquer: high resolution structural information on TRP channel fragments Strategies for lead discovery: application of footprint similarity targeting HIVgp41.Role of lipids in virus replication Amphipathic properties of HIV-1 gp41 fusion inhibitors.Approaches for identification of HIV-1 entry inhibitors targeting gp41 pocket Computer-Aided Approaches for Targeting HIVgp41.

P2860

Q22583513-5D7DCD07-4FB7-4750-A7B0-9F9B73278824 Q24675493-5DA21077-23F3-4DFD-A767-777044860DAE Q27010058-52076E08-CC3A-451F-A93C-B1052427B321 Q27485578-D8468AA1-CA68-4961-A9B8-D7312186B3D5 Q27486639-BD4FC0C3-1FDD-4B77-ABF7-8F7B0A8D3B2A Q27487974-1DACCE70-8CE4-41AD-9AE8-F8B51B62BCD5 Q27653846-7EB38910-A640-471D-8350-B3A0029CA962 Q27657158-1DE8EB7D-8EDB-4D10-B09F-D111075DFB1C Q27664086-6A378386-C8CD-4A0C-A053-9B747C90E81C Q27666255-AB485252-D697-41C8-A660-085A648DB695 Q27678660-046F6FE1-BA55-4F97-86FB-B4B5CF54D386 Q28286428-53C636DA-BC93-4C54-96DA-AF5B6DC76414 Q33282526-3335E456-8DB3-428B-BC59-DA4ED0135A3E Q33334027-85AF3CAE-433D-424D-9D26-628E245A8787 Q33429777-011744DB-2935-4ACB-AB0E-380A4FE09A96 Q33592517-C96B3C7B-B6E4-43E4-8829-F867E949C969 Q33840121-78039408-EE94-4E26-98FF-A080FF57715D Q33935016-E6F6089D-89B6-4293-A70A-ED7DABDF26ED Q33966639-8B06B75B-9E78-484B-9D07-A3BD4BC3DA95 Q34021319-9A648BD0-1B88-4352-AEE7-A5818C17C505 Q34438246-E80BF68B-3B59-4A30-9219-D7C63E324857 Q34517381-D160CCD5-7A3A-4201-B013-996EF643F5AF Q34522767-07502129-A03E-4599-B9FA-7DC582A3B367 Q34659242-94F987EE-3D4F-40D8-9158-E3B26692CF94 Q35183338-C61795D9-298A-438C-94E4-1F7501528E9E Q35563298-FD51B974-A0EF-4C2F-8D03-E17B7D8126AC Q35600803-69C31F49-5D99-4710-A845-183BA2675701 Q35615810-475C7E8F-7919-43E4-B4EC-FA46BB60E58B Q35826908-754F22CE-7C85-4D0F-85B8-3B7D01A1B9C2 Q36291082-BBC3A8F7-5F58-4835-94B7-31F653CCCFBE Q36316050-D1967AD1-2AA4-4311-B70A-0D10B194AE27 Q36643050-4C8ECF6C-9DBF-41A0-91F7-5F913622CBE3 Q36946831-9EA55099-6D9B-4DAB-8386-51A08AB8538A Q37115773-D307AFE9-1460-4084-9489-125DBE745DD5 Q37399782-FAA3F996-45EE-485F-A558-DF26C2C64A23 Q37552860-A0756DED-8D24-449D-A5E4-40A0A2D641D1 Q37882865-6EB28ADE-5D49-46DB-8E39-92E0F9CCE182 Q37951610-D2AB28B7-4297-49E7-87E6-2A82FAE3EBB9 Q38076321-9F9BBAD7-9391-44ED-BA69-51DF28C6DA87 Q38111393-B88742D8-E855-45A4-9ACC-665B71E5CBB2

P2860

Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion

http://www.wikidata.org/entity/Q35080356

description

2006 nî lūn-bûn

@nan

2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion

@ast

Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion

@en

type

label

Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion

@ast

Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion

@en

prefLabel

Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion

@ast

Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion

@en

P1433

Q35080356-5CC74246-FBDA-4C6A-9DB6-FBE06E6C63F2

P1476

Q35080356-7382A4BE-DCFC-463A-9AD3-8125EE45C652

P2093

Q35080356-2A49F93B-DF24-48A7-AC19-582BBF5B792D

Q35080356-2F305B71-F636-4601-A373-614762133143

Q35080356-5022EE38-9006-4B2F-A3D0-A09A264F4034

Q35080356-592B743B-0549-47AF-BF42-C9B936A7C1F4

Q35080356-858639D3-9134-49D6-B6DC-0BE78998D434

Q35080356-B5AC8620-46BB-4C41-BAAB-FDFFECDBA1AA

P2860

Q35080356-0E1E01EC-ADA2-49A3-B83B-1D200346CBEB

Q35080356-1994DBB5-6D23-4C5F-A0DE-9BA317BC86FF

Q35080356-34F6E8C5-60C5-46CA-8AB2-6E33068776F4

Q35080356-3AE1460D-05DF-4DC0-BCC5-D2D44BCA6D92

Q35080356-4236A9D9-F8A9-4E8C-BE53-225FB4A449F2

Q35080356-46FF4E4C-9647-4D40-A97F-26E117E63CB0

Q35080356-70B0BAC4-7AF3-4751-8E00-6A658D8BDBFF

Q35080356-77664BAC-E8EA-4019-A349-930338FBF4F3

Q35080356-84FA7244-B94E-4221-9E60-7C9913A25D73

Q35080356-85AABB01-2998-43ED-A934-81D4AEE52FE9

P304

Q35080356-DFF0C211-0948-4866-8FAC-AA05D0235C1A

P31

Q35080356-8B2FB9CE-BCD1-41C2-8324-B55B7676B2B5

P356

Q35080356-BE42558F-02FF-4339-9AA3-86324C778BCD

P407

Q35080356-B9183774-73C7-4AE9-AE7C-94CF19276B0E

P433

Q35080356-2B0F836D-8592-49E8-AFA7-500044B3DD44

P478

Q35080356-1A29CB36-2F24-4D09-B1DA-35DD6FB5393F

P577

Q35080356-032C91DD-1523-4929-BBFD-9C68F2011B99

P5875

Q35080356-1860B939-EA21-4F3A-8277-056D19BFA493

P698

Q35080356-8CABF94D-39B5-4E8F-9FCC-F9498E4C18A9

P932

Q35080356-682E3F8D-BAA0-4D28-A6C9-7072AF53FE40

P356

PNAS.0601036103

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion

@en

P2093

Bing Chen

http://www.w3.org/2001/XMLSchema#string

Gary Frey

http://www.w3.org/2001/XMLSchema#string

Robert T Schooley

http://www.w3.org/2001/XMLSchema#string

Sophia Rits-Volloch

http://www.w3.org/2001/XMLSchema#string

Stephen C Harrison

http://www.w3.org/2001/XMLSchema#string

X-Q Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket

Retrovirus envelope domain at 1.7 angstrom resolution

Core structure of gp41 from the HIV envelope glycoprotein

Atomic structure of the ectodomain from HIV-1 gp41

Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glycoprotein ectodomain

A synthetic peptide inhibitor of human immunodeficiency virus replication: correlation between solution structure and viral inhibition

Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection

Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target

Structure-based identification of small molecule antiviral compounds targeted to the gp41 core structure of the human immunodeficiency virus type 1

Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements

P304

13938-13943

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.0601036103

http://www.w3.org/2001/XMLSchema#string

P407

P433

38

http://www.w3.org/2001/XMLSchema#string

P478

103

http://www.w3.org/2001/XMLSchema#string

P577

2006-09-08T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6826513

http://www.w3.org/2001/XMLSchema#string

P698

16963566

http://www.w3.org/2001/XMLSchema#string

P932

1599892

http://www.w3.org/2001/XMLSchema#string