Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion
about
Small-molecule inhibitors of dengue-virus entryPotent D-peptide inhibitors of HIV-1 entryProtease-resistant peptide design-empowering nature's fragile warriors against HIVA fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodiesViral membrane fusionStructures and Mechanisms of Viral Membrane Fusion Proteins: Multiple Variations on a Common ThemeStructure of the HIV-1 gp41 Membrane-Proximal Ectodomain Region in a Putative Prefusion Conformation † , ‡Structural and biological mimicry of protein surface recognition by / -peptide foldamersDesign of a Potent D-Peptide HIV-1 Entry Inhibitor with a Strong Barrier to ResistanceBroad Distribution of Energetically Important Contacts across an Extended Protein InterfaceEnhancement of α-Helix Mimicry by an α/β-Peptide Foldamer via Incorporation of a Dense Ionic Side-Chain ArrayInternal dynamics of the homotrimeric HIV-1 viral coat protein gp41 on multiple time scalesA novel fluorescence intensity screening assay identifies new low-molecular-weight inhibitors of the gp41 coiled-coil domain of human immunodeficiency virus type 1Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses.Stable extended human immunodeficiency virus type 1 gp41 coiled coil as an effective target in an assay for high-affinity fusion inhibitors.Contribution of light chain residues to high affinity binding in an HIV-1 antibody explored by combinatorial scanning mutagenesisOrigins of resistance to the HIVgp41 viral entry inhibitor T20.Vaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates.A low-molecular-weight entry inhibitor of both CCR5- and CXCR4-tropic strains of human immunodeficiency virus type 1 targets a novel site on gp41Synthetic Fab fragments that bind the HIV-1 gp41 heptad repeat regions.Dissection of SNARE-driven membrane fusion and neuroexocytosis by wedging small hydrophobic molecules into the SNARE zipperInhibition of HIV Entry by Targeting the Envelope Transmembrane Subunit gp41.Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactionsSide chain requirements for affinity and specificity in D5, an HIV-1 antibody derived from the VH1-69 germline segmentInhibition of adenovirus replication by a trisubstituted piperazin-2-one derivative.Biochemistry and biophysics of HIV-1 gp41 - membrane interactions and implications for HIV-1 envelope protein mediated viral-cell fusion and fusion inhibitor designHigh-Throughput HIV-Cell Fusion Assay for Discovery of Virus Entry InhibitorsTargeting HIV-1 gp41-induced fusion and pathogenesis for anti-viral therapyIdentification of a specific region in the e1 fusion protein involved in zinc inhibition of semliki forest virus fusion.A fluorescence polarization assay using an engineered human respiratory syncytial virus F protein as a direct screening platformScreening and Functional Profiling of Small-Molecule HIV-1 Entry and Fusion Inhibitors.Development of Small-molecule HIV Entry Inhibitors Specifically Targeting gp120 or gp41Design of Small Molecules with HIV Fusion Inhibitory Property Based on Gp41 Interaction AssaySC29EK, a peptide fusion inhibitor with enhanced alpha-helicity, inhibits replication of human immunodeficiency virus type 1 mutants resistant to enfuvirtideDivide and conquer: high resolution structural information on TRP channel fragmentsStrategies for lead discovery: application of footprint similarity targeting HIVgp41.Role of lipids in virus replicationAmphipathic properties of HIV-1 gp41 fusion inhibitors.Approaches for identification of HIV-1 entry inhibitors targeting gp41 pocketComputer-Aided Approaches for Targeting HIVgp41.
P2860
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P2860
Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion
description
2006 nî lūn-bûn
@nan
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion
@ast
Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion
@en
type
label
Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion
@ast
Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion
@en
prefLabel
Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion
@ast
Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion
@en
P2093
P2860
P356
P1476
Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion
@en
P2093
Robert T Schooley
Sophia Rits-Volloch
Stephen C Harrison
P2860
P304
13938-13943
P356
10.1073/PNAS.0601036103
P407
P577
2006-09-08T00:00:00Z