Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer - Wikidata - awgldk - TriplyDB

Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer

Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer

http://www.wikidata.org/entity/Q35085696

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An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development Variants and haplotypes in Flap endonuclease 1 and risk of gallbladder cancer and gallstones: a population-based study in China Hypomorphic PCNA mutation underlies a human DNA repair disorder.The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers.Novel method for site-specific induction of oxidative DNA damage reveals differences in recruitment of repair proteins to heterochromatin and euchromatin High risk of benzo[α]pyrene-induced lung cancer in E160D FEN1 mutant mice Okazaki fragment maturation involves α-segment error editing by the mammalian FEN1/MutSα functional complex.Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression.The role of DNA exonucleases in protecting genome stability and their impact on ageing.The DNase domain-containing protein TATDN1 plays an important role in chromosomal segregation and cell cycle progression during zebrafish eye development.The wonders of flap endonucleases: structure, function, mechanism and regulation.The FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation.Oxidized base damage and single-strand break repair in mammalian genomes: role of disordered regions and posttranslational modifications in early enzymes.The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once.Single-molecule characterization of Fen1 and Fen1/PCNA complexes acting on flap substrates Role of PCNA and RFC in promoting Mus81-complex activity.Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.Overexpression of Flap Endonuclease 1 Correlates with Enhanced Proliferation and Poor Prognosis of Non-Small-Cell Lung Cancer.SUMO-1 modification of FEN1 facilitates its interaction with Rad9-Rad1-Hus1 to counteract DNA replication stress

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Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer

http://www.wikidata.org/entity/Q35085696

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Fen1 mutations that specifical ...... e aneuploidy-associated cancer

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Fen1 mutations that specifical ...... e aneuploidy-associated cancer

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Fen1 mutations that specifical ...... e aneuploidy-associated cancer

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Fen1 mutations that specifical ...... e aneuploidy-associated cancer

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Binghui Shen

http://www.w3.org/2001/XMLSchema#string

Gerd P Pfeifer

http://www.w3.org/2001/XMLSchema#string

Huifang Dai

http://www.w3.org/2001/XMLSchema#string

Jun Wu

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Kemp H Kernstine

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Lei Su

http://www.w3.org/2001/XMLSchema#string

Li Zheng

http://www.w3.org/2001/XMLSchema#string

Mian Zhou

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Muralidhar L Hegde

http://www.w3.org/2001/XMLSchema#string

Qin Huang

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P2860

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates

Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity

Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

Endogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancer

Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair

Lagging strand DNA synthesis at the eukaryotic replication fork involves binding and stimulation of FEN-1 by proliferating cell nuclear antigen

Purification and characterization of the DNA polymerase alpha associated exonuclease: the RTH1 gene product.

Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair

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1052-1067

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scholarly article

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10.1038/CR.2011.35

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7

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3129403

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