Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression.
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Endoreplication and polyploidy: insights into development and diseaseThe "virgin birth", polyploidy, and the origin of cancerMammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrityExcessive abundance of common resources deters social responsibility.Transient endoreplication down-regulates the kinesin-14 HSET and contributes to genomic instability.Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal.Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markersThe Cytolethal Distending Toxin Subunit CdtB of Helicobacter hepaticus Promotes Senescence and Endoreplication in Xenograft Mouse Models of Hepatic and Intestinal Cell Lines.The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers.Low levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in Drosophila endocycling cells.YY1 suppresses FEN1 over-expression and drug resistance in breast cancerOkazaki fragment maturation involves α-segment error editing by the mammalian FEN1/MutSα functional complex.Error-promoting DNA synthesis in ovarian cancer cells.Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability.The FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation.Linking genomic reorganization to tumor initiation via the giant cell cyclePolycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication.Size Does Matter: Why Polyploid Tumor Cells are Critical Drug Targets in the War on Cancer.Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancer.Epigenetic Determinants of Cancer.Oxygen nanobubbles revert hypoxia by methylation programming.Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2.Triptolide-Assisted Phosphorylation of p53 Suppresses Inflammation-Induced NF-κB Survival Pathways in Cancer Cells.Hyperdiploid tumor cells increase phenotypic heterogeneity within Glioblastoma tumors.Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer.The relationship between cell apoptosis dysfunction and FEN1 E160D mutation in lupus nephritis patients.Endoreplication: The Good, the Bad, and the Ugly.Disentangling the aneuploidy and senescence paradoxes: a study of triploid breast cancers non-responsive to neoadjuvant therapy.Roles of Polyploid/Multinucleated Giant Cancer Cells in Metastasis and Disease Relapse Following Anticancer Treatment.SUMO-1 modification of FEN1 facilitates its interaction with Rad9-Rad1-Hus1 to counteract DNA replication stress
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P2860
Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression.
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
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2012年學術文章
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2012年學術文章
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name
Polyploid cells rewire DNA dam ...... rriers for tumour progression.
@ast
Polyploid cells rewire DNA dam ...... rriers for tumour progression.
@en
type
label
Polyploid cells rewire DNA dam ...... rriers for tumour progression.
@ast
Polyploid cells rewire DNA dam ...... rriers for tumour progression.
@en
prefLabel
Polyploid cells rewire DNA dam ...... rriers for tumour progression.
@ast
Polyploid cells rewire DNA dam ...... rriers for tumour progression.
@en
P2093
P2860
P356
P1476
Polyploid cells rewire DNA dam ...... rriers for tumour progression.
@en
P2093
Binghui Shen
Changwei Liu
Charles Wang
Gerd P Pfeifer
Huifang Dai
John Zhong
Julio Garcia-Aguilar
P2860
P2888
P356
10.1038/NCOMMS1825
P407
P577
2012-05-08T00:00:00Z
P5875
P6179
1039598042