The ubiquitin proteolytic system and pathogenesis of human diseases: a novel platform for mechanism-based drug targeting.
about
Skeletal muscle wasting and renewal: a pivotal role of myokine IL-6Cullin-RING ligases in regulation of autophagyA dynamic interface between ubiquitylation and cAMP signalingNovel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae.Aggresome formation and neurodegenerative diseases: therapeutic implicationsRING-H2 protein WSSV249 from white spot syndrome virus sequesters a shrimp ubiquitin-conjugating enzyme, PvUbc, for viral pathogenesisExpression Profiling of WSSV ORF 199 and Shrimp Ubiquitin Conjugating Enzyme in WSSV Infected Penaeus monodonUp-regulation of beta-catenin by a viral oncogene correlates with inhibition of the seven in absentia homolog 1 in B lymphoma cellsTargeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapyPost-translational control of IL-1β via the human papillomavirus type 16 E6 oncoprotein: a novel mechanism of innate immune escape mediated by the E3-ubiquitin ligase E6-AP and p53.Ubiquitin-proteasome pathway and cellular responses to oxidative stress.Amyloid transition of ubiquitin on silver nanoparticles produced by pulsed laser ablation in liquid as a function of stabilizer and single-point mutations.Immunoproteasome subunit LMP2 expression is deregulated in Sjogren's syndrome but not in other autoimmune disorders.The 19S proteasomal lid subunit POH1 enhances the transcriptional activation by Mitf in osteoclasts.Proteasome-dependent regulation of signal transduction in retinal pigment epithelial cells.Small ubiquitin-like modifying protein isopeptidase assay based on poliovirus RNA polymerase activity.Identification of key genes and pathways for peri-implantitis through the analysis of gene expression data.A novel proteasome inhibitor NPI-0052 as an anticancer therapy.Differential display identifies overexpression of the USP36 gene, encoding a deubiquitinating enzyme, in ovarian cancerImpairment of the ubiquitin-proteasome pathway in RPE alters the expression of inflammation related genesLutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells.Validation of UBE2C protein as a prognostic marker in node-positive breast cancer.Proteasome inactivation promotes p38 mitogen-activated protein kinase-dependent phosphatidylinositol 3-kinase activation and increases interleukin-8 production in retinal pigment epithelial cells.Synthesis and pharmacology of proteasome inhibitors.Discovery of Therapeutic Deubiquitylase Effector Molecules: Current Perspectives.Chaperoning proteins for destruction: diverse roles of Hsp70 chaperones and their co-chaperones in targeting misfolded proteins to the proteasomeDeubiquitinases and the new therapeutic opportunities offered to cancer.Induction of apoptosis by proteasome inhibitors in B-CLL cells is associated with downregulation of CD23 and inactivation of Notch2.A critical role of Hrd1 in the regulation of optineurin degradation and aggresome formation.Targeting the ubiquitin E3 ligase MuRF1 to inhibit muscle atrophy.Oxidative inactivation of the proteasome in retinal pigment epithelial cells. A potential link between oxidative stress and up-regulation of interleukin-8.Expression Profile of Penaeus monodon Ubiquitin Conjugating Enzyme (PmUbc) at Protein Level in White spot syndrome virus Challenged ShrimpThe proteasome: a target of oxidative damage in cultured human retina pigment epithelial cells.Expression of K6W-ubiquitin in lens epithelial cells leads to upregulation of a broad spectrum of molecular chaperones.PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins.A strategy to calculate the patterns of nutrient consumption by microorganisms applying a two-level optimisation principle to reconstructed metabolic networks.Pleiotropic effects of Ubp6 loss on drug sensitivities and yeast prion are due to depletion of the free ubiquitin pool.Down-regulation of the de-ubiquitinating enzyme ubiquitin-specific protease 2 contributes to tumor necrosis factor-alpha-induced hepatocyte survival.Deubiquitylating enzymes and drug discovery: emerging opportunities.Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genes.
P2860
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P2860
The ubiquitin proteolytic system and pathogenesis of human diseases: a novel platform for mechanism-based drug targeting.
description
2003 nî lūn-bûn
@nan
2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The ubiquitin proteolytic syst ...... echanism-based drug targeting.
@ast
The ubiquitin proteolytic syst ...... echanism-based drug targeting.
@en
type
label
The ubiquitin proteolytic syst ...... echanism-based drug targeting.
@ast
The ubiquitin proteolytic syst ...... echanism-based drug targeting.
@en
prefLabel
The ubiquitin proteolytic syst ...... echanism-based drug targeting.
@ast
The ubiquitin proteolytic syst ...... echanism-based drug targeting.
@en
P356
P1476
The ubiquitin proteolytic syst ...... echanism-based drug targeting.
@en
P304
P356
10.1042/BST0310474
P577
2003-04-01T00:00:00Z