Transcriptional profiling reveals a role for RORalpha in regulating gene expression in obesity-associated inflammation and hepatic steatosis. - Wikidata - awgldk - TriplyDB

Transcriptional profiling reveals a role for RORalpha in regulating gene expression in obesity-associated inflammation and hepatic steatosis.

Transcriptional profiling reveals a role for RORalpha in regulating gene expression in obesity-associated inflammation and hepatic steatosis.

http://www.wikidata.org/entity/Q35095209

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Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors α- and γ-mediated transactivation Transcriptional regulation of hepatic lipogenesis Orphan nuclear receptors and the regulation of nutrient metabolism: understanding obesity RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo Effects of circadian clock genes and environmental factors on cognitive aging in old adults in a Taiwanese population.Genome-wide methylation analysis reveals differentially methylated loci that are associated with an age-dependent increase in bovine fibroblast response to LPS.RORα decreases oxidative stress through the induction of SOD2 and GPx1 expression and thereby protects against nonalcoholic steatohepatitis in mice.Altered clock gene expression in obese visceral adipose tissue is associated with metabolic syndrome CD44 plays a critical role in regulating diet-induced adipose inflammation, hepatic steatosis, and insulin resistance The identification of naturally occurring neoruscogenin as a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (NR1F1).Increased apolipoprotein A5 expression in human and rat non-alcoholic fatty livers.RNA expression profiling in depressed patients suggests retinoid-related orphan receptor alpha as a biomarker for antidepressant response.Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis RORα, a potential tumor suppressor and therapeutic target of breast cancer.Retinoic acid-related orphan receptors α and γ: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivity Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism.Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder.Genetic Variants of Retinoic Acid Receptor-Related Orphan Receptor Alpha Determine Susceptibility to Type 2 Diabetes Mellitus in Han Chinese.Inhibition of RORα/γ suppresses atherosclerosis via inhibition of both cholesterol absorption and inflammation Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control.Retinoic acid-related orphan receptor α regulates diurnal rhythm and fasting induction of sterol 12α-hydroxylase in bile acid synthesis Disrupting Hepatocyte Cyp51 from Cholesterol Synthesis Leads to Progressive Liver Injury in the Developing Mouse and Decreases RORC Signalling.Nuclear receptor retinoid-related orphan receptor alpha promotes apoptosis but is reduced in human gastric cancer.Experimental and clinical aspects of melatonin and clock genes in diabetes.Metabolic Characterization of a Novel RORα Knockout Mouse Model without Ataxia Retinoic acid receptor-related orphan receptor α stimulates adipose tissue inflammation by modulating endoplasmic reticulum stress.Transcription Factor GLIS3: A New and Critical Regulator of Postnatal Stages of Mouse Spermatogenesis.Gene-specific alterations of hepatic gene expression by ligand activation or hepatocyte-selective inhibition of retinoid X receptor-α signalling during inflammation.Synthesis and biological evaluation of novel urea- and guanidine-based derivatives for the treatment of obesity-related hepatic steatosis.The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORα/γ.Liver-specific deletion of RORα aggravates diet-induced nonalcoholic steatohepatitis by inducing mitochondrial dysfunction.Genetic Biomarkers on Age-Related Cognitive Decline.Proteome-based identification of apolipoprotein A-IV as an early diagnostic biomarker in liver fibrosis.Fructose and glucose regulate mammalian target of rapamycin complex 1 and can activate lipogenic gene expression via distinct pathways.Depot-Specific Response of Adipose Tissue to Diet-Induced Inflammation: The Retinoid-Related Orphan Receptor α (RORα) Involved?Melatonin suppresses activation of hepatic stellate cells through RORα-mediated inhibition of 5-lipoxygenase.The nuclear retinoid-related orphan receptor-α regulates adipose tissue glyceroneogenesis in addition to hepatic gluconeogenesis.Genetic variations in RORα are associated with chronic obstructive pulmonary disease.The nuclear retinoid-related orphan receptor RORα controls circadian thermogenic programming in white fat depots.Retinoic acid receptor-related orphan receptor α-induced activation of adenosine monophosphate-activated protein kinase results in attenuation of hepatic steatosis.

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Transcriptional profiling reveals a role for RORalpha in regulating gene expression in obesity-associated inflammation and hepatic steatosis.

http://www.wikidata.org/entity/Q35095209

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年论文

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Transcriptional profiling reve ...... mmation and hepatic steatosis.

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Transcriptional profiling reve ...... mmation and hepatic steatosis.

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Transcriptional profiling reve ...... mmation and hepatic steatosis.

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Transcriptional profiling reve ...... mmation and hepatic steatosis.

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Transcriptional profiling reve ...... mmation and hepatic steatosis.

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Transcriptional profiling reve ...... mmation and hepatic steatosis.

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PHYSIOLGENOMICS.00206.2010

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Physiological Genomics

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Transcriptional profiling reve ...... mmation and hepatic steatosis.

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Carl D Bortner

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Hong Soon Kang

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Ju Youn Beak

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Kevin Gerrish

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Kyoko Okamoto

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Laura M DeGraff

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Taira Wada

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Wen Xie

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Yukimasa Takeda

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P2860

Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha

The orphan nuclear receptor ROR alpha is a negative regulator of the inflammatory response

Cidea is associated with lipid droplets and insulin sensitivity in humans

Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling

Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors

Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands

Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice

X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha

All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta

Inflammation and metabolic disorders

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10.1152/PHYSIOLGENOMICS.00206.2010

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13

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Anton M. Jetten

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