Roles of BRCA1 in DNA damage repair: a link between development and cancer.
about
BRCA1 affects global DNA methylation through regulation of DNMT1A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpointCharacterization of a novel large deletion and single point mutations in the BRCA1 gene in a Greek cohort of families with suspected hereditary breast cancerBRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolutionBRCA1 and estrogen/estrogen receptor in breast cancer: where they interact?Current progress of genetically engineered pig models for biomedical researchGenetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closureBRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin.Modulatory effects of alpha- and gamma-tocopherols on 4-hydroxyestradiol induced oxidative stresses in MCF-10A breast epithelial cells.Crosstalk between the DNA damage response, histone modifications and neovascularisation.Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activationHuman Fanconi anemia monoubiquitination pathway promotes homologous DNA repair.Identifying novel genes and biological processes relevant to the development of cancer therapy-induced mucositis: An informative gene network analysis.Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells.Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells.The effectiveness of cucurbitacin B in BRCA1 defective breast cancer cells.ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiencyPARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers?Loss of the BRCA1-interacting helicase BRIP1 results in abnormal mammary acinar morphogenesis.miR-638 mediated regulation of BRCA1 affects DNA repair and sensitivity to UV and cisplatin in triple-negative breast cancer.Hyperplasia and spontaneous tumor development in the gynecologic system in mice lacking the BRCA1-Delta11 isoform.Promoter methylation and expression changes of BRCA1 in cancerous tissues of patients with sporadic breast cancer.A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase.Effects of BRCA1 transgene expression on murine mammary gland development and mutagen-induced mammary neoplasia.The dual lives of bidirectional promoters.Deregulation of BRCA1 leads to impaired spatiotemporal dynamics of γ-H2AX and DNA damage responses in Huntington's diseaseBreast cancer 1 (BRCA1)-deficient embryos develop normally but are more susceptible to ethanol-initiated DNA damage and embryopathies.Positive selection in the evolution of cancer.TUSC4 functions as a tumor suppressor by regulating BRCA1 stabilityMEK inhibitor GSK1120212-mediated radiosensitization of pancreatic cancer cells involves inhibition of DNA double-strand break repair pathways.Mitochondria and familial predisposition to breast cancer.Distinct patterns of structural and numerical chromosomal instability characterize sporadic ovarian cancer.A PP1-binding motif present in BRCA1 plays a role in its DNA repair function.BRCA1 Expression is an Important Biomarker for Chemosensitivity: Suppression of BRCA1 Increases the Apoptosis via Up-regulation of p53 and p21 During Cisplatin Treatment in Ovarian Cancer CellsApplication of RNAi-induced gene expression profiles for prognostic prediction in breast cancerBRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity.Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1Systematic discovery and characterization of regulatory motifs in ENCODE TF binding experiments.Ammonium tetrathiomolybdate treatment targets the copper transporter ATP7A and enhances sensitivity of breast cancer to cisplatinLow-dose environmental radiation, DNA damage, and cancer: the possible contribution of psychological factors.
P2860
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P2860
Roles of BRCA1 in DNA damage repair: a link between development and cancer.
description
2003 nî lūn-bûn
@nan
2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Roles of BRCA1 in DNA damage repair: a link between development and cancer.
@ast
Roles of BRCA1 in DNA damage repair: a link between development and cancer.
@en
type
label
Roles of BRCA1 in DNA damage repair: a link between development and cancer.
@ast
Roles of BRCA1 in DNA damage repair: a link between development and cancer.
@en
prefLabel
Roles of BRCA1 in DNA damage repair: a link between development and cancer.
@ast
Roles of BRCA1 in DNA damage repair: a link between development and cancer.
@en
P356
P1476
Roles of BRCA1 in DNA damage repair: a link between development and cancer.
@en
P2093
Chu-Xia Deng
Rui-Hong Wang
P304
P356
10.1093/HMG/DDG082
P478
12 Spec No 1
P577
2003-04-01T00:00:00Z