Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant.
about
Association of insulin receptor substrate 1 with simian virus 40 large T antigenCrystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificityETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylationDevelopment of new insulin-like growth factor-1 receptor kinase inhibitors using catechol mimics.CLAVATA1 dominant-negative alleles reveal functional overlap between multiple receptor kinases that regulate meristem and organ development.A phase I trial of the IGF-1R antibody Cixutumumab in combination with temsirolimus in patients with metastatic breast cancer.Protein kinase C-delta is an important signaling molecule in insulin-like growth factor I receptor-mediated cell transformation.Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis.Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasisThe contradictions of the insulin-like growth factor 1 receptor.The reciprocal regulation of gamma-synuclein and IGF-I receptor expression creates a circuit that modulates IGF-I signaling.The role of the insulin-like growth factor system in adrenocortical tumourigenesis.Pregnancy-associated plasma protein-A expression in human breast cancer.Cancer gene therapy.Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor.Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts.Overexpression of insulin-like growth factor-1 (IGF-I) receptor and the invasiveness of cultured keloid fibroblasts.Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancerInsulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury.Regulation of cyclooxygenase-2 (COX-2) expression in human pancreatic carcinoma cells by the insulin-like growth factor-I receptor (IGF-IR) system.Expression of insulin-like growth factors (IGFs), their receptors and IGF binding protein-3 in normal, benign and malignant smooth muscle tissues.Insulin-like growth factor I receptor signaling in transformation by src oncogenes.Clinical implications of insulin-like growth factor 1 system in early-stage cervical cancer.Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo.The matrix metalloproteinase-9 regulates the insulin-like growth factor-triggered autocrine response in DU-145 carcinoma cells.Neoplastic transformation induced by insulin receptor substrate-1 overexpression requires an interaction with both Grb2 and Syp signaling molecules.The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma.Antitumor effects of novel shorter truncated insulin-like growth factor I receptors.Generation of a conditionally transformed murine embryonic fibroblast cell line using doxycycline-dependent IGF-1R overexpression.Failure of the bovine papillomavirus to transform mouse embryo fibroblasts with a targeted disruption of the insulin-like growth factor I receptor genes.The role of the insulin-like growth factor-I receptor in cancer.A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells.Expression of an IGF-I receptor dominant negative mutant induces apoptosis, inhibits tumorigenesis and enhances chemosensitivity in Ewing's sarcoma cells.Aberrant expression and activation of insulin-like growth factor-1 receptor (IGF-1R) are mediated by an induction of IGF-1R promoter activity and stabilization of IGF-1R mRNA and contributes to growth factor independence and increased survival of thSynthetic peptide sequence from the C-terminus of the insulin-like growth factor-I receptor that induces apoptosis and inhibition of tumor growth.Inhibition of insulin-like growth factor-I mitogenic action by zinc chelation is associated with a decreased mitogen-activated protein kinase activation in RAT-1 fibroblasts.Expression of the insulin-like growth factor 1 receptor (IGF-1R) in breast cancer cells: evidence for a regulatory role of dolichyl phosphate in the transition from an intracellular to an extracellular IGF-1 pathway.Dissociation between resistance to apoptosis and the transformed phenotype in IGF-I receptor signaling.Antisense phosphorothioate oligodeoxynucleotide down-regulation of the insulin-like growth factor I receptor in ovarian cancer cells.The baculovirus anti-apoptotic p35 protein promotes transformation of mouse embryo fibroblasts.
P2860
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P2860
Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant.
description
1994 nî lūn-bûn
@nan
1994 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի մարտին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
name
Dominant negative inhibition o ...... owth factor I receptor mutant.
@ast
Dominant negative inhibition o ...... owth factor I receptor mutant.
@en
type
label
Dominant negative inhibition o ...... owth factor I receptor mutant.
@ast
Dominant negative inhibition o ...... owth factor I receptor mutant.
@en
prefLabel
Dominant negative inhibition o ...... owth factor I receptor mutant.
@ast
Dominant negative inhibition o ...... owth factor I receptor mutant.
@en
P2093
P2860
P356
P1476
Dominant negative inhibition o ...... owth factor I receptor mutant.
@en
P2093
P2860
P304
P356
10.1073/PNAS.91.6.2181
P407
P577
1994-03-01T00:00:00Z