Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair. - Wikidata - awgldk - TriplyDB

Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair.

Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair.

http://www.wikidata.org/entity/Q35099098

about

ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair Novel Biological Approaches for Testing the Contributions of Single DSBs and DSB Clusters to the Biological Effects of High LET Radiation Genotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cells Diseases associated with defective responses to DNA damage DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice Looking beneath the surface to determine what makes DNA damage deleterious The Structural Basis for Substrate Recognition by Mammalian Polynucleotide Kinase 3′ Phosphatase Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates Evolutionary and Structural Analyses of Mammalian Haloacid Dehalogenase-type Phosphatases AUM and Chronophin Provide Insight into the Basis of Their Different Substrate Specificities Drugging the addict: non-oncogene addiction as a target for cancer therapy Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair The structural basis of XRCC1-mediated DNA repair Role of polynucleotide kinase/phosphatase in mitochondrial DNA repair Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex.Structural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complex Non-homologous end joining: emerging themes and unanswered questions.Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time Maintaining genome stability in the nervous system.Proteomic snapshot of breast cancer cell cycle: G1/S transition point.Pol β associated complex and base excision repair factors in mouse fibroblasts.Mammalian base excision repair: the forgotten archangel XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair.Neurological disorders associated with DNA strand-break processing enzymes.Analyses of anticancer drugs by capillary electrophoresis: a review.A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair.Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3 Recognition and repair of chemically heterogeneous structures at DNA ends The modulation of phosphatase expression impacts the proliferation efficiency of HSV-1 in infected astrocytes.DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair Repair of the major lesion resulting from C5'-oxidation of DNA.Mutations in PNKP cause recessive ataxia with oculomotor apraxia type 4.Assessing 'radiosensitivity' with kinetic profiles of γ-H2AX, 53BP1 and BRCA1 foci.DNA end processing by polynucleotide kinase/phosphatase.Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of mitochondrial genome.Base excision repair: contribution to tumorigenesis and target in anticancer treatment paradigms Association of ATM activation and DNA repair with induced radioresistance after low-dose irradiation.Special AT-rich Sequence-binding Protein 1 (SATB1) Functions as an Accessory Factor in Base Excision Repair.Reprint of "Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair".Ribonucleolytic resection is required for repair of strand displaced nonhomologous end-joining intermediates.A systems approach implicates nuclear receptor targeting in the Atp7b(-/-) mouse model of Wilson's disease.

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Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair.

http://www.wikidata.org/entity/Q35099098

description

2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年學術文章

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name

Tidying up loose ends: the rol ...... se in DNA strand break repair.

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Tidying up loose ends: the rol ...... se in DNA strand break repair.

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type

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Tidying up loose ends: the rol ...... se in DNA strand break repair.

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Tidying up loose ends: the rol ...... se in DNA strand break repair.

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Tidying up loose ends: the rol ...... se in DNA strand break repair.

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Tidying up loose ends: the rol ...... se in DNA strand break repair.

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J.TIBS.2011.01.006

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Trends in Biochemical Sciences

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Tidying up loose ends: the rol ...... se in DNA strand break repair.

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Ismail Abdou

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J N Mark Glover

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Michael Weinfeld

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R Daniel Aceytuno

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Rajam S Mani

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P2860

Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage

Molecular characterization of a human DNA kinase

DNA Damage, Aging, and Cancer

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1

The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4

Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK

Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining

Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV

Mutations in PNKP cause microcephaly, seizures and defects in DNA repair

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