Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas - Wikidata - awgldk - TriplyDB

Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

http://www.wikidata.org/entity/Q35102345

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Current Proceedings in the Molecular Dissection of Hepatocellular Adenomas: Review and Hands-on Guide for Diagnosis Protein tyrosine phosphatases as wardens of STAT signaling Engaged for survival: From cadherin ligation to STAT3 activation STAT3 inhibitors for cancer therapy: Have all roads been explored?Somatic STAT3 mutations in large granular lymphocytic leukemia Signal transducer and activator of transcription 3 (STAT3) protein suppresses adenoma-to-carcinoma transition in Apcmin/+ mice via regulation of Snail-1 (SNAI) protein stability Growth arrest and DNA damage 45G down-regulation contributes to Janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma Suramin alleviates glomerular injury and inflammation in the remnant kidney A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia.The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia.Intracellular signaling prevents effective blockade of oncogenic gp130 mutants by neutralizing antibodies.Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells Next-generation genomic profiling of hepatocellular adenomas: a new era of individualized patient care.HNF1α inhibition triggers epithelial-mesenchymal transition in human liver cancer cell lines.Cross talk between the TM4SF5/focal adhesion kinase and the interleukin-6/STAT3 pathways promotes immune escape of human liver cancer cells.Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer.Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease.A gp130-Src-YAP module links inflammation to epithelial regeneration.Modulation of STAT3 folding and function by TRiC/CCT chaperonin.DNA binding reduces the dissociation rate of STAT1 dimers and impairs the interdimeric exchange of protomers.Therapeutic potential of AZD1480 for the treatment of human glioblastoma Impact of the N-Terminal Domain of STAT3 in STAT3-Dependent Transcriptional Activity Interleukin-6 and its receptor, key players in hepatobiliary inflammation and cancer Chronic inflammation, immune escape, and oncogenesis in the liver: a unique neighborhood for novel intersections.STAT3 can serve as a hit in the process of malignant transformation of primary cells.Overview of hepatocellular adenoma in Japan.The Ying and Yang of STAT3 in Human Disease How normal is the liver in which the inflammatory type hepatocellular adenoma develops?Hepatocyte-stellate cell cross-talk in the liver engenders a permissive inflammatory microenvironment that drives progression in hepatocellular carcinoma mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice Molecular classification of hepatocellular adenomas.A membrane penetrating peptide aptamer inhibits STAT3 function and suppresses the growth of STAT3 addicted tumor cells.High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma STAT3 mutations identified in human hematologic neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model.SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer.Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma.THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors The two faces of IL-6 in the tumor microenvironment.

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Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

http://www.wikidata.org/entity/Q35102345

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2011 nî lūn-bûn

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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2011 թվականի հունիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

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Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

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type

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Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

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Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

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Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

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Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

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Journal of Experimental Medicine

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Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

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Charles Balabaud

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Gabrielle Couchy

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Jeanne Tran Van Nhieu

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Karine Poussin

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Michel P Bihl

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Mohamed Amessou

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Tina Izard

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P2860

The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6

Three-dimensional structure of the Stat3beta homodimer bound to DNA

Immunity, Inflammation, and Cancer

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

Bi-allelic inactivation of TCF1 in hepatic adenomas

STAT3 mutations in the hyper-IgE syndrome

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

STATs in cancer inflammation and immunity: a leading role for STAT3

Stats: transcriptional control and biological impact

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1359-1366

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10.1084/JEM.20110283

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7

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208

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Valérie Paradis

Jessica Zucman-Rossi

Paulette Bioulac-Sage

Jean Charles Nault

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