T-cell properties determine disease site, clinical presentation, and cellular pathology of experimental autoimmune encephalomyelitis
about
Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells.Site-specific chemokine expression regulates central nervous system inflammation and determines clinical phenotype in autoimmune encephalomyelitisCytokine-regulated neutrophil recruitment is required for brain but not spinal cord inflammation during experimental autoimmune encephalomyelitis.The extracellular domain of myelin oligodendrocyte glycoprotein elicits atypical experimental autoimmune encephalomyelitis in rat and Macaque speciesAbsence of IFN-γ increases brain pathology in experimental autoimmune encephalomyelitis-susceptible DRB1*0301.DQ8 HLA transgenic mice through secretion of proinflammatory cytokine IL-17 and induction of pathogenic monocytes/microglia into the centraMassive apoptosis in lymphoid organs in animal models for primary and secondary progressive multiple sclerosisIFN-gamma signaling in the central nervous system controls the course of experimental autoimmune encephalomyelitis independently of the localization and composition of inflammatory foci.Anti-inflammatory mechanisms of IFN-γ studied in experimental autoimmune encephalomyelitis reveal neutrophils as a potential target in multiple sclerosis.Heterogeneity of EAE mediated by multiple distinct T-effector subsets.The Th17-ELR+ CXC chemokine pathway is essential for the development of central nervous system autoimmune diseaseIL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition.Regional CNS responses to IFN-gamma determine lesion localization patterns during EAE pathogenesisModeling the heterogeneity of multiple sclerosis in animalsThe interdependent, overlapping, and differential roles of type I and II IFNs in the pathogenesis of experimental autoimmune encephalomyelitis.Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells.Encephalitogenic T cells that stably express both T-bet and ROR gamma t consistently produce IFNgamma but have a spectrum of IL-17 profilesModeling multiple sclerosis in laboratory animals.Opposing Roles of Interferon-Gamma on Cells of the Central Nervous System in Autoimmune Neuroinflammation.The contribution of neutrophils to CNS autoimmunity.The more the merrier? Scoring, statistics and animal welfare in experimental autoimmune encephalomyelitis.Pre-existing central nervous system lesions negate cytokine requirements for regional experimental autoimmune encephalomyelitis development.Deletion of IL-4Rα in the BALB/c mouse is associated with altered lesion topography and susceptibility to experimental autoimmune encephalomyelitis.
P2860
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P2860
T-cell properties determine disease site, clinical presentation, and cellular pathology of experimental autoimmune encephalomyelitis
description
2004 nî lūn-bûn
@nan
2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
T-cell properties determine di ...... l autoimmune encephalomyelitis
@ast
T-cell properties determine di ...... l autoimmune encephalomyelitis
@en
type
label
T-cell properties determine di ...... l autoimmune encephalomyelitis
@ast
T-cell properties determine di ...... l autoimmune encephalomyelitis
@en
prefLabel
T-cell properties determine di ...... l autoimmune encephalomyelitis
@ast
T-cell properties determine di ...... l autoimmune encephalomyelitis
@en
P2093
P2860
P1476
T-cell properties determine di ...... l autoimmune encephalomyelitis
@en
P2093
Joshua Leeman
Martin Dorf
Michael Berman
Rebecca Leeman
Rod Bronson
Sara Abromson-Leeman
P2860
P304
P356
10.1016/S0002-9440(10)63410-4
P407
P577
2004-11-01T00:00:00Z