The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways. - Wikidata - awgldk - TriplyDB

The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways.

The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways.

http://www.wikidata.org/entity/Q35103813

about

GSK-3β: A Bifunctional Role in Cell Death Pathways Identification of an antiapoptotic protein complex at death receptors Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics DDX3, a potential target for cancer treatment Molecular and biochemical trajectories from diabetes to Alzheimer's disease: A critical appraisal Pro-Apoptotic Kinase Levels in Cerebrospinal Fluid as Potential Future Biomarkers in Alzheimer's Disease Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease Gsk3 Signalling and Redox Status in Bipolar Disorder: Evidence from Lithium Efficacy GSK3beta in ethanol neurotoxicity The role of GSK3beta in the development of the central nervous system A New alpha5beta1 integrin-dependent survival pathway through GSK3beta activation in leukemic cells Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcome Inhibition of glycogen synthase kinase 3β ameliorates D-GalN/LPS-induced liver injury by reducing endoplasmic reticulum stress-triggered apoptosis GSK3A is redundant with GSK3B in modulating drug resistance and chemotherapy-induced necroptosis Fenugreek Seed Powder Nullified Aluminium Chloride Induced Memory Loss, Biochemical Changes, Aβ Burden and Apoptosis via Regulating Akt/GSK3β Signaling Pathway Inhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survival Endoplasmic reticulum stress in diabetic hearts abolishes erythropoietin-induced myocardial protection by impairment of phospho-glycogen synthase kinase-3beta-mediated suppression of mitochondrial permeability transition Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells: role in cell proliferation and survival NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy The intersection between DNA damage response and cell death pathways Glycogen synthase kinase-3 inhibition sensitizes pancreatic cancer cells to TRAIL-induced apoptosis Modulation of GSK-3β activity in Venezuelan equine encephalitis virus infection Activation of GABA(B) receptors inhibits protein kinase B/glycogen synthase kinase 3 signaling.Glycogen synthase kinase-3 in the etiology and treatment of mood disorders.Is glycogen synthase kinase-3 a central modulator in mood regulation?Genomic duplication and overexpression of TJP2/ZO-2 leads to altered expression of apoptosis genes in progressive nonsyndromic hearing loss DFNA51.GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals Inhibition of PI3K-Akt signaling blocks exercise-mediated enhancement of adult neurogenesis and synaptic plasticity in the dentate gyrus Glycogen synthase kinase-3 inhibition disrupts nuclear factor-kappaB activity in pancreatic cancer, but fails to sensitize to gemcitabine chemotherapy Involvment of cytosolic and mitochondrial GSK-3beta in mitochondrial dysfunction and neuronal cell death of MPTP/MPP-treated neurons Dynamic telomerase gene suppression via network effects of GSK3 inhibition Involvement of VDAC, Bax and ceramides in the efflux of AIF from mitochondria during curcumin-induced apoptosis.Mercury-induced hepatotoxicity in zebrafish: in vivo mechanistic insights from transcriptome analysis, phenotype anchoring and targeted gene expression validation.c-FLIPL enhances anti-apoptotic Akt functions by modulation of Gsk3β activity.Deletion of CXCR4 in cardiomyocytes exacerbates cardiac dysfunction following isoproterenol administration Oxidative stress promotes D-GalN/LPS-induced acute hepatotoxicity by increasing glycogen synthase kinase 3β activity.Glycogen synthase kinase-3β is involved in ligand-dependent activation of transcription and cellular localization of the glucocorticoid receptor.Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3).Glycogen Synthase Kinase-3 regulates multiple myeloma cell growth and bortezomib-induced cell death Vpr-host interactions during HIV-1 viral life cycle.

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The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways.

http://www.wikidata.org/entity/Q35103813

description

2006 nî lūn-bûn

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2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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J.PNEUROBIO.2006.07.006

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Progress in Neurobiology

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The paradoxical pro- and anti- ...... apoptosis signaling pathways.

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Eléonore Beurel

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Richard S Jope

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P2860

Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity

p53 has a direct apoptogenic role at the mitochondria

Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors

Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

Identification of c-MYC as a target of the APC pathway

Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

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10.1016/J.PNEUROBIO.2006.07.006

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apoptotic process

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