Inhibition of cathepsin K increases modeling-based bone formation, and improves cortical dimension and strength in adult ovariectomized monkeys. - Wikidata - awgldk - TriplyDB

Inhibition of cathepsin K increases modeling-based bone formation, and improves cortical dimension and strength in adult ovariectomized monkeys.

Inhibition of cathepsin K increases modeling-based bone formation, and improves cortical dimension and strength in adult ovariectomized monkeys.

http://www.wikidata.org/entity/Q35109866

about

From disease to treatment: from rare skeletal disorders to treatments for osteoporosis Emerging Therapies for Osteoporosis Modulating Bone Resorption and Bone Formation in Opposite Directions in the Treatment of Postmenopausal Osteoporosis Long-term safety of antiresorptive treatment: bone material, matrix and mineralization aspects Osteoclasts: more than 'bone eaters'.Chronic kidney disease and the skeleton.Effects of odanacatib on bone matrix mineralization in rhesus monkeys are similar to those of alendronate Contributions of Nonhuman Primates to Research on Aging.Bone modeling and remodeling: potential as therapeutic targets for the treatment of osteoporosis.Long-term treatment with odanacatib maintains normal trabecular biomechanical properties in ovariectomized adult monkeys as demonstrated by micro-CT-based finite element analysis.Molecular and cellular basis of bone resorption.Osteoporosis therapy: a novel insight from natural homeostatic system in the skeleton.Co-administration of antiresorptive and anabolic agents: a missed opportunity.Novel targets for the prevention of osteoporosis - lessons learned from studies of metabolic bone disorders.Cathepsin K Inhibition: A New Mechanism for the Treatment of Osteoporosis.Cathepsin K Controls Cortical Bone Formation by Degrading Periostin.Pharmacological and biological therapeutic strategies for osteogenesis imperfecta.The role of biochemical of bone turnover markers in osteoporosis and metabolic bone disease: a consensus paper of the Belgian Bone Club.Sustained Modeling-Based Bone Formation During Adulthood in Cynomolgus Monkeys May Contribute to Continuous BMD Gains With Denosumab.Cathepsin K Localizes to Equine Bone In Vivo and Inhibits Bone Marrow Stem and Progenitor Cells Differentiation In Vitro.An Ectosteric Inhibitor of Cathepsin K Inhibits Bone Resorption in Ovariectomized Mice.Effects of Long-Term Odanacatib Treatment on Bone Gene Expression in Ovariectomized Adult Rhesus Monkeys: Differentiation From Alendronate.The effect of cathepsin K inhibitor on osteoclastic activity compared to alendronate and enamel matrix protein.Nonclinical and clinical pharmacological characterization of the potent and selective cathepsin K inhibitor MIV-711.Cathepsin K inhibition preserves compressive load in lumbar vertebrae of osteoporotic monkeys

P2860

Q26764854-B9EDE4FA-7DB1-4F43-B859-A0008AF19911 Q26782109-248C7731-D1F9-42DA-9554-D3390AC63FA0 Q27022580-2E312D34-6979-4755-BDA4-8C818EB87C25 Q27025945-9465A2A2-F914-4177-9140-75891391002F Q33993757-662F347C-AF46-4DEC-A05B-FAA3322F6DCC Q35755179-E84198B3-C551-49DE-8F07-D7EF1CA2EC4E Q37051593-48057B11-9C08-43CF-A828-2C0495C7361F Q37265056-2401ECC8-707D-4D97-813C-204BC16A4512 Q37661855-27D32DA3-EF14-4C38-91AD-1779476F9EFF Q37720677-CC93ED35-A7F5-4099-B605-D204D14A7E53 Q38249864-3128E20A-4909-40C7-899C-CE301E7E228B Q38257484-4E0C31D2-C588-47D6-AEB1-5202E4859D13 Q38367370-2CCEEFB2-4F2D-4309-AE6F-F6B1A80B5931 Q38470745-2D48F24F-EC9C-4DE1-9FA4-3B5A85C30563 Q38579689-94EFD854-2544-4D1C-9B09-F6A007ED000C Q38891355-3A8B3DDD-CC52-40A9-966A-B845F59D7871 Q38998578-9DDD529D-BCE8-4804-B8E4-11FCBAF17189 Q40828040-79BF4F2C-8BB2-4F88-A518-5AD214D744C4 Q41482012-B8878D8C-2B4A-4752-94CF-972CB5518FAD Q49387831-DEB97CBE-DD51-477B-B351-61F8B0DCB6A2 Q52761114-B7D3BEC1-B329-4430-9D10-972E2FBF148D Q53808499-0B30E649-6FDD-40A2-B4A0-511D4A168B62 Q54185201-DD2200E9-E931-45B6-A867-0A3B78309010 Q54987147-67E17308-E3A6-4955-86F9-3450DEAFAD11 Q58593477-DC075A05-37D8-43B7-944B-5BE00B1D0F87

P2860

Inhibition of cathepsin K increases modeling-based bone formation, and improves cortical dimension and strength in adult ovariectomized monkeys.

http://www.wikidata.org/entity/Q35109866

description

2014 nî lūn-bûn

@nan

2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Inhibition of cathepsin K incr ...... adult ovariectomized monkeys.

@ast

Inhibition of cathepsin K incr ...... adult ovariectomized monkeys.

@en

type

label

Inhibition of cathepsin K incr ...... adult ovariectomized monkeys.

@ast

Inhibition of cathepsin K incr ...... adult ovariectomized monkeys.

@en

prefLabel

Inhibition of cathepsin K incr ...... adult ovariectomized monkeys.

@ast

Inhibition of cathepsin K incr ...... adult ovariectomized monkeys.

@en

P1433

Q35109866-20410831-1E72-4342-97A2-8F37D001F450

P1476

Q35109866-01E09011-7479-468A-BAE7-C387413AC42C

P2093

Q35109866-68A96F24-2732-4C40-9476-CFADBC0C310E

Q35109866-6E05681F-7769-4DBA-9ACE-C065CF7A3479

Q35109866-880A446B-0DF2-4B09-BD06-9C266F01BF34

Q35109866-9C3A5382-06D0-46DE-9376-B40DBA826AA8

Q35109866-BA59C3F4-D0BB-479F-AFD4-C6084FB432F2

Q35109866-CC8BDAC7-DD7F-48E4-9BC2-4549E52D8A99

Q35109866-FADFD63D-DEF3-4EC4-947A-5626ED820130

P2860

Q35109866-0520BE97-5E18-441C-BB59-0B8CEA3D8187

Q35109866-1102B992-025F-499F-B849-09164910DB1B

Q35109866-20E50B0A-6EA2-4473-9F0D-8C7809FEE338

Q35109866-23DEC609-A434-42B9-9FCE-BA795C9A244D

Q35109866-2D22360E-78C3-46AB-A545-4F3CC2555B27

Q35109866-31405AF2-9021-41E5-AB90-3165299F3C44

Q35109866-46BA323F-5DE5-4CBE-AF05-9F0793A0C71F

Q35109866-5AEDED6B-40E8-4FD7-A283-EB7FE77DC72D

Q35109866-5E450B54-3039-45BF-8583-D3C3B499703C

Q35109866-76ABAA42-A027-4AB4-A608-05F3D5F12879

P304

Q35109866-1155ACAA-9898-43A5-996A-E64268A1D881

P31

Q35109866-50AA5DA1-FA54-4593-A8DE-D484C878BDC0

P356

Q35109866-02F83740-C584-48BC-8F55-76623C59B418

P433

Q35109866-CA9E769E-DB47-4AD6-BE65-63667C4F674B

P478

Q35109866-90FF0739-D754-4E2C-B8FD-36387600DAC1

P577

Q35109866-1680AAFD-A9CC-4663-99A3-58A9F0F65C9F

P698

Q35109866-55E44E8B-EF54-4010-B7A2-C2378A03A657

P356

P1433

Journal of Bone and Mineral Research

P1476

Inhibition of cathepsin K incr ...... adult ovariectomized monkeys.

@en

P2093

Brenda L Pennypacker

http://www.w3.org/2001/XMLSchema#string

Charles M Chen

http://www.w3.org/2001/XMLSchema#string

Helen Zheng

http://www.w3.org/2001/XMLSchema#string

Le T Duong

http://www.w3.org/2001/XMLSchema#string

Mary Belfast

http://www.w3.org/2001/XMLSchema#string

Mei-Shu Shih

http://www.w3.org/2001/XMLSchema#string

Rana Samadfam

http://www.w3.org/2001/XMLSchema#string

P2860

Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis

Denosumab, a fully human RANKL antibody, reduced bone turnover markers and increased trabecular and cortical bone mass, density, and strength in ovariectomized cynomolgus monkeys.

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.

Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey.

Pathogenesis of bone fragility in women and men.

Denosumab and bisphosphonates: different mechanisms of action and effects.

Biomechanics of bone: determinants of skeletal fragility and bone quality.

The aging of Wolff's "law": ontogeny and responses to mechanical loading in cortical bone.

Are women with thicker cortices in the femoral shaft at higher risk of subtrochanteric/diaphyseal fractures? The study of osteoporotic fractures.

Bone quality--the material and structural basis of bone strength and fragility.

P304

1847-1858

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1002/JBMR.2211

http://www.w3.org/2001/XMLSchema#string

P433

8

http://www.w3.org/2001/XMLSchema#string

P478

29

http://www.w3.org/2001/XMLSchema#string

P577

2014-08-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

24591096

http://www.w3.org/2001/XMLSchema#string