Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity. - Wikidata - awgldk - TriplyDB

Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity.

Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity.

http://www.wikidata.org/entity/Q35111750

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Inhibition of MerTK increases chemosensitivity and decreases oncogenic potential in T-cell acute lymphoblastic leukemia Targeting receptor tyrosine kinases in gastric cancer The Gas6/TAM System and Multiple Sclerosis MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer MERTK receptor tyrosine kinase is a therapeutic target in melanoma.UNC1062, a new and potent Mer inhibitor.TAM receptor tyrosine kinases: expression, disease and oncogenesis in the central nervous system.UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor.Prolonged exposure to a Mer ligand in leukemia: Gas6 favors expression of a partial Mer glycoform and reveals a novel role for Mer in the nucleus.Promotion of glioblastoma cell motility by enhancer of zeste homolog 2 (EZH2) is mediated by AXL receptor kinase Axl as a mediator of cellular growth and survival Mer590, a novel monoclonal antibody targeting MER receptor tyrosine kinase, decreases colony formation and increases chemosensitivity in non-small cell lung cancer Efferocytosis produces a prometastatic landscape during postpartum mammary gland involution.Mechanisms of AXL overexpression and function in Imatinib-resistant chronic myeloid leukemia cells.Mer receptor tyrosine kinase is frequently overexpressed in human non-small cell lung cancer, confirming resistance to erlotinib.AXL is a potential therapeutic target in dedifferentiated and pleomorphic liposarcomas.Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors.Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer.Combined inhibition of AXL, Lyn and p130Cas kinases block migration of triple negative breast cancer cells.Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer Chitosan nanoparticle-mediated delivery of miRNA-34a decreases prostate tumor growth in the bone and its expression induces non-canonical autophagy Biodegradable interstitial release polymer loading a novel small molecule targeting Axl receptor tyrosine kinase and reducing brain tumour migration and invasion.TAM receptors in leukemia: expression, signaling, and therapeutic implications.Phase 1 trial of dasatinib plus erlotinib in adults with recurrent malignant glioma Inhibiting receptor tyrosine kinase AXL with small molecule inhibitor BMS-777607 reduces glioblastoma growth, migration, and invasion in vitro and in vivo MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis Biology of the TAM receptors.UNC569, a novel small-molecule mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo MERTK as a novel therapeutic target in head and neck cancer.Aberrant Mer receptor tyrosine kinase expression contributes to leukemogenesis in acute myeloid leukemia.MERTK controls melanoma cell migration and survival and differentially regulates cell behavior relative to AXL.TAM receptors Tyro3 and Mer as novel targets in colorectal cancer.G-749, a novel FLT3 kinase inhibitor, can overcome drug resistance for the treatment of acute myeloid leukemia.n-Butylidenephthalide Regulated Tumor Stem Cell Genes EZH2/AXL and Reduced Its Migration and Invasion in Glioblastoma.Acquired resistance to BRAF inhibition in BRAFV600E mutant gliomas AXL induces epithelial-to-mesenchymal transition and regulates the function of breast cancer stem cells.How to improve the immunogenicity of chemotherapy and radiotherapy.Macrophage-tumor crosstalk: role of TAMR tyrosine kinase receptors and of their ligands.The receptor tyrosine kinase Axl in cancer: biological functions and therapeutic implications.

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Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity.

http://www.wikidata.org/entity/Q35111750

description

2010 nî lūn-bûn

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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2010 թվականի ապրիլին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Inhibition of Mer and Axl rece ...... and improved chemosensitivity.

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Inhibition of Mer and Axl rece ...... and improved chemosensitivity.

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Inhibition of Mer and Axl rece ...... and improved chemosensitivity.

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Inhibition of Mer and Axl rece ...... and improved chemosensitivity.

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Inhibition of Mer and Axl rece ...... and improved chemosensitivity.

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Inhibition of Mer and Axl rece ...... and improved chemosensitivity.

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1535-7163.MCT-09-0707

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Molecular Cancer Therapeutics

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Inhibition of Mer and Axl rece ...... and improved chemosensitivity.

@en

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Amy K Keating

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Andrew M Donson

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Andrew Thorburn

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Ashley E Jones

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Dana B Salzberg

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Douglas K Graham

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Grace K Kim

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Jean M Mulcahy

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Kathryn Ware

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Nicholas K Foreman

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P2860

Cloning and mRNA expression analysis of a novel human protooncogene, c-mer

Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis

Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival

Autophagy in the Pathogenesis of Disease

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia

Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration

Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy

Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family

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1298-1307

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9

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20423999

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3138539

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