Phospholipase Cζ binding to PtdIns(4,5)P2 requires the XY-linker region
about
Phospholipase C-ζ-induced Ca2+ oscillations cause coincident cytoplasmic movements in human oocytes that failed to fertilize after intracytoplasmic sperm injectionPhosphoinositides: tiny lipids with giant impact on cell regulationPLCζ or PAWP: revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesisUnderstanding fertilization through intracytoplasmic sperm injection (ICSI)Novel regulation of PLCζ activity via its XY-linkerHuman PLCζ exhibits superior fertilization potency over mouse PLCζ in triggering the Ca(2+) oscillations required for mammalian oocyte activationSperm-specific post-acrosomal WW-domain binding protein (PAWP) does not cause Ca2+ release in mouse oocytes.PLCζ causes Ca(2+) oscillations in mouse eggs by targeting intracellular and not plasma membrane PI(4,5)P(2).Disulphide bridges of phospholipase C of Chlamydomonas reinhardtii modulates lipid interaction and dimer stabilityIdentification of Leptospira interrogans phospholipase C as a novel virulence factor responsible for intracellular free calcium ion elevation during macrophage death.Oocyte activation and phospholipase C zeta (PLCζ): diagnostic and therapeutic implications for assisted reproductive technology.Essential Role of the EF-hand Domain in Targeting Sperm Phospholipase Cζ to Membrane Phosphatidylinositol 4,5-Bisphosphate (PIP2).Phospholipase Cζ rescues failed oocyte activation in a prototype of male factor infertility.Chimeras of sperm PLCζ reveal disparate protein domain functions in the generation of intracellular Ca2+ oscillations in mammalian eggs at fertilization.Occurrence and functional significance of the transcriptome in bovine (Bos taurus) spermatozoa.Starting a new life: sperm PLC-zeta mobilizes the Ca2+ signal that induces egg activation and embryo development: an essential phospholipase C with implications for male infertility.Comparative biology of sperm factors and fertilization-induced calcium signals across the animal kingdom.Sperm PLCζ: from structure to Ca2+ oscillations, egg activation and therapeutic potential.Novel signalling mechanism and clinical applications of sperm-specific PLCζ.Egg Activation at Fertilization.Mutations in PLCδ1 associated with hereditary leukonychia display divergent PIP2 hydrolytic function.Calcium influx and sperm-evoked calcium responses during oocyte maturation and egg activation.
P2860
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P2860
Phospholipase Cζ binding to PtdIns(4,5)P2 requires the XY-linker region
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Phospholipase Cζ binding to PtdIns(4,5)P2 requires the XY-linker region
@ast
Phospholipase Cζ binding to PtdIns(4,5)P2 requires the XY-linker region
@en
type
label
Phospholipase Cζ binding to PtdIns(4,5)P2 requires the XY-linker region
@ast
Phospholipase Cζ binding to PtdIns(4,5)P2 requires the XY-linker region
@en
prefLabel
Phospholipase Cζ binding to PtdIns(4,5)P2 requires the XY-linker region
@ast
Phospholipase Cζ binding to PtdIns(4,5)P2 requires the XY-linker region
@en
P2093
P2860
P356
P1476
Phospholipase Cζ binding to PtdIns(4,5)P2 requires the XY-linker region
@en
P2093
Brian L Calver
George Nounesis
Karl Swann
Khalil Elgmati
Maria Theodoridou
P2860
P304
P356
10.1242/JCS.083485
P407
P577
2011-07-05T00:00:00Z